Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents [0.03%]
经典Einthoven气道收缩模型在啮齿动物吸入型支气管扩张剂研究中的应用
Alexander McNamara,Maria Teresa Pulido-Rios,Sharath S Hegde et al.
Alexander McNamara et al.
Introduction: The discovery of novel bronchodilators that treat human respiratory disorders has been guided by an array of animal models of bronchoconstriction which differ in technical complexity and experimental endpoin...
Henner Simianer,Friederike Köhn
Henner Simianer
The Göttingen Minipig is a laboratory animal of worldwide importance. The breed was developed in the 1960's at the University of Göttingen, Germany, using the founder breeds Minnesota Minipigs, Vietnamese Potbelly Pig and German Landrace....
QTc shortening with a new investigational cancer drug: a brief case study [0.03%]
一种新型抗癌药物诱发QT间期缩短的病例报告
Herbert M Himmel,Michael Hoffmann
Herbert M Himmel
Introduction: BAY-79 is an inhibitor of receptor tyrosine kinases with high selectivity versus other kinases. Species scaling, complicated by nonlinear pharmacokinetics, predicted a C(max.u) of 36-178nmol/L at the human e...
Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys [0.03%]
清醒状态下携带植入式遥测装置的食蟹猴的心肺联合评价
S Authier,Paul Haefner,S Fournier et al.
S Authier et al.
Female cynomolgus monkeys were surgically implanted with telemetry transmitters recording ECG (DII), arterial pressure, physical activity, body temperature, and tidal volume. Respiratory rate (RR) and tidal volume (TV) were monitored simult...
Utility of positive controls in assessing assay sensitivity in ICH S7B and ICH E14 guidance for evaluation of QT/QTc interval prolongation [0.03%]
阳性对照物在ICH S7B和ICH E14指南中评估QT/QTc间期延长评价中的作用
Alan Y Chiang,Craig H Mallinckrodt,Alex A Dmitrienko et al.
Alan Y Chiang et al.
Positive controls have often been used in nonclinical and clinical cardiovascular safety studies to evaluate the study's assay sensitivity with respect to drug-induced prolongation of the QT interval of the electrocardiogram (ECG). If the s...
Cardiovascular safety assessments in the conscious telemetered dog: utilisation of super-intervals to enhance statistical power [0.03%]
清醒状态下的遥测犬心血管安全性评估：利用超区间增强统计功效
A Sivarajah,S Collins,M R Sutton et al.
A Sivarajah et al.
Introduction: ICH S7A and S7B guidelines recommend the use of conscious animals for assessment of non-clinical cardiovascular safety of new chemical entities prior to testing in humans. Protocol design and data analysis t...
Ethical implications of using the minipig in regulatory toxicology studies [0.03%]
小型猪在监管毒理学研究中使用的伦理影响
John Webster,Peter Bollen,Herwig Grimm et al.
John Webster et al.
Two key questions are addressed in this article. What are the potential harms to minipigs relative to the harms for dogs and non-human primates and can these harms be reduced more easily in minipigs than in other species? Are there potentia...
Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition [0.03%]
一种快速筛选含咪唑类化合物HO-1抑制剂的简便方法
Jason Z Vlahakis,Mona N Rahman,Gheorghe Roman et al.
Jason Z Vlahakis et al.
Introduction: Sensitive assays for measuring heme oxygenase activity have been based on the gas-chromatographic detection of carbon monoxide using elaborate, expensive equipment. The present study describes a rapid and co...
Evaluation of blood pressure measurement using a miniature blood pressure transmitter with jacketed external telemetry in cynomolgus monkeys [0.03%]
袖带式外置发射器微型血压计在食蟹猴中的血压检测效果评估研究
Carrie McMahon,Andrea Z Mitchell,Jessica L Klein et al.
Carrie McMahon et al.
Introduction: Current techniques used to accurately determine arterial blood pressure (BP) in conscious, unrestrained monkeys require invasive telemetry. This study evaluated the functionality of an implanted miniature te...
Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals [0.03%]
用于犬和猴慢性实验的开胸手术及高质量心电图信号的采集方法
Tracy A Henriques,Thomas W Beck,Christopher L Douglas et al.
Tracy A Henriques et al.
Introduction: Assessment of cardiovascular parameters, including the electrocardiogram (ECG) is required by the regulatory guidelines. In safety pharmacology studies, this is typically done using chronically implanted rad...