Roy Forster,Philippe Ancian,Merete Fredholm et al.
Roy Forster et al.
The potential of the minipig as a platform for future developments in genomics, high density biology, transgenic technology, in vitro toxicology and related emerging technologies was reviewed. Commercial interests in the pig as an agricultu...
Gerd Bode,Peter Clausing,Frederic Gervais et al.
Gerd Bode et al.
In this article we review the value and utility of the minipig as an animal model in regulatory toxicity testing. Our review is based on detailed consideration of the comparative biology of the minipig, and of the practical features of toxi...
The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations [0.03%]
关于在新药和化学品毒性试验中重新思考使用迷你猪的项目：结论与建议
Roy Forster,Gerd Bode,Lars Ellegaard et al.
Roy Forster et al.
The objective of the RETHINK project was to evaluate the potential impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity testing that can contribute to the replacement, refinement and reduction of anima...
Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits [0.03%]
validations of 123I-MIBG作为兔血小板标记物的非侵入性成像标志物的验证
Hom N S Saihkay,Karen J Rickards,Clive P Page et al.
Hom N S Saihkay et al.
Introduction: Recent in vitro studies in our laboratory have demonstrated that platelets are necessary for leukocyte recruitment and airway remodelling in models of allergic airway inflammation, and also migrate to lung t...
Characterising the time-course of microvascular vasodilator responses in humans using Laser Doppler Fluximetry and iontophoresis [0.03%]
利用激光多普勒流血计和电渗法描述人体微血管 vasodilator 反应的时间过程
Markos Klonizakis,Krishna Lingam,Gillian Manning et al.
Markos Klonizakis et al.
Introduction: Laser Doppler Fluximetry (LDF) and iontophoresis of vasodilators have been combined to assess microvascular flow and vasodilator reactivity in humans for many years and their use established. However, tradit...
Welfare of the minipig with special reference to use in regulatory toxicology studies [0.03%]
小型猪福利的特殊参考：用于法规毒理学研究中
Lars Ellegaard,Andrew Cunningham,Sandra Edwards et al.
Lars Ellegaard et al.
This paper reviews the animal welfare challenges associated with the use of minipigs in toxicology testing, and compares these to published knowledge on the other widely used non-rodent species (dogs and non-human primates). Welfare challen...
Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice [0.03%]
评估安全药理学研究中一种便捷的评价啮齿类动物视力的方法：碘化钠对白毛和黑毛大鼠和小鼠视锐度及视网膜形态的影响
William S Redfern,Sharon Storey,Karen Tse et al.
William S Redfern et al.
Introduction: We have evaluated the ability of a semi-automated, optomotor reflex method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice. ...
Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products [0.03%]
小型猪在药物、化学品和其他产品开发中的监管适用性
Jan Willem van der Laan,John Brightwell,Peter McAnulty et al.
Jan Willem van der Laan et al.
As part of the RETHINK European FP6 Project an overview of the acceptability and usefulness of minipigs has been carried out in the regulatory arenas of human and veterinary pharmaceuticals, food additives, cosmetics, biocides and agrochemi...
EEG in the FEAB model: measurement of electroencephalographical burst suppression and seizure liability in safety pharmacology [0.03%]
FEAB模型中的EEG检测：安全药理学中的脑电图爆发抑制和癫痫发作易感性测量
H J van der Linde,B Van Deuren,Y Somers et al.
H J van der Linde et al.
Introduction: The purpose of this study was to explore the integration of electroencephalographical (EEG) measurements into the fentanyl/etomidate-anaesthetised Beagle (FEAB) model in order to detect burst suppression and...
Non-clinical models: validation, study design and statistical consideration in safety pharmacology [0.03%]
非临床模型：安全药理学中的验证、实验设计和统计考虑因素
M K Pugsley,R Towart,S Authier et al.
M K Pugsley et al.
The current issue of the Journal of Pharmacological and Toxicological Methods (JPTM) focuses exclusively on safety pharmacology methods. This is the 7th year the Journal has published on this topic. Methods and models that specifically rela...