In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry [0.03%]
telemetry在心血管安全药理学研究中对每搏输出量、心输出量和系统血管阻力的计算机建模
Pascal Champeroux,Jérôme Thireau,Jean-Yves Le Guennec et al.
Pascal Champeroux et al.
The principle of proportionality of the systolic area of the central aortic pressure to stroke volume (SV) has been long known. The aim of the present work was to evaluate an in silico solution derived from this principle for modelling SV (...
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee [0.03%]
合作科学的实践：健康与环境科学研究所(HESI)心脏安全委员会20年的回顾与展望
Jennifer B Pierson,Brian Berridge,Ksenia Blinova et al.
Jennifer B Pierson et al.
The Health and Environmental Sciences Institute (HESI) is a nonprofit organization dedicated to resolving global health challenges through collaborative scientific efforts across academia, regulatory authorities and the private sector. Coll...
A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates [0.03%]
清醒非人灵长类动物QT间期评估中当代对照、历史对照和跨实验室对照的性能比较
Matthew M Abernathy,Derek D Best,Derek J Leishman
Matthew M Abernathy
Cardiovascular safety pharmacology and toxicology studies include vehicle control animals in most studies. Electrocardiogram data on common vehicles is accumulated relatively quickly. In the interests of the 3Rs principles it may be useful ...
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium [0.03%]
紫外光谱法测定壳聚糖在水介质中释放β-石竹烯浓度的方法
Marcus Vinicius Alves Barros,Keila Cardoso Teixeira,Laene da Silva Santos et al.
Marcus Vinicius Alves Barros et al.
Myrcene (β-myrcene), found in essential oils from plant species such as hops and cannabis, has many advantageous properties, but its use is limited due to volatility and low solubility in water. One way to circumvent these limitations is t...
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms [0.03%]
仔猪血液采集的新方法：评估24小时皮质醇谱型及药物对昼夜和超短波节律影响的方法
Frederik Rode,Christoffer Bundgaard,Johan Areberg et al.
Frederik Rode et al.
We developed a novel, stress-free blood sampling method for minipigs, allowing continuous cortisol monitoring over 24 h. Baseline cortisol levels exhibited both ultradian and diurnal rhythms. During nighttime, smaller ultradian rhythms over...
Use of human Caco-2 cells and HPAE-PAD for α-glucosidase assay [0.03%]
人Caco-2细胞和HPAE-PAD的α-葡萄糖苷酶测定法中的应用研究
Yuki Ikeda,So Nishimoto,Ying Qiao et al.
Yuki Ikeda et al.
To measure α-glucosidase activity, rat intestinal acetone powder is commonly used as a source of α-glucosidase, and the mutarotase-glucose oxidase (GOD) methods commonly used to quantitate glucose produced by enzymatic hydrolysis of the s...
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity [0.03%]
药物心脏毒性的非临床检测中基于药理学的数据库构建和发展
Donald De Alwis,C Michael Foley,Eugene Herman et al.
Donald De Alwis et al.
The Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee designed and created a publicly accessible database with an initial set of 128 pharmacologically defined pharmaceutical agents, many with known cardiotoxic prop...
M Breda,M Pilla,M Brazzarola et al.
M Breda et al.
GLP test facility management refers to the proper management and organization of a facility that conducts studies according to GLP regulations. Compliance with GLP regulations is necessary for data generated in such facilities to be accepte...
Development, validation, and clinical application of a UPLC-MS/MS method for omadacycline determination in human serum [0.03%]
一种测定人体血清中奥马达西林的UPLC-MS/MS方法的开发、验证及临床应用研究
Guo Suhang,Zheng Ren,Fan Xudong et al.
Guo Suhang et al.
Background: Omadacycline is the first aminomethyl-tetracycline variety to successfully enter clinical applications. To support regular therapeutic drug monitoring (TDM) in clinical practice, an ultra-high-performance liqu...
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients [0.03%]
高效液相色谱-串联质谱法测定人血浆硫酸多粘菌素并用于危重症患者的临床应用研究
Xiaoying Wang,Qiang Sun,Xiaojing Li et al.
Xiaoying Wang et al.
Colistin is a last-resort antibiotic used for treating infections caused by carbapenem-resistant Gram-negative bacteria, particularly in critically patients, nevertheless its therapeutic window is narrow, and requires monitoring. A determin...