Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities [0.03%]
贝叶斯方法实现多个诱导多能干细胞分化心肌细胞(proarrhythmia敏感性)的客观比较
Tetsuro Wakatsuki,Neil Daily,Sunao Hisada et al.
Tetsuro Wakatsuki et al.
The one-size-fits-all approach has been the mainstream in medicine, and the well-defined standards support the development of safe and effective therapies for many years. Advancing technologies, however, enabled precision medicine to treat ...
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva [0.03%]
苯基硫脲介导的实验性脱色可降低斑马鱼幼体中戊四唑的惊厥反应
Savita Kumari,Damanpreet Singh
Savita Kumari
Zebrafish larvae exposed to chemoconvulsants show behavioral seizures and electrographic abnormalities similar to the other mammalian models, making it a potential tool in epilepsy research. During the embryonic stage, zebrafish remains tra...
Optimization of an in vitro method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells [0.03%]
一种用于评估吸入性药物肺渗透性的体外方法的优化：使用肺泡上皮细胞法
Nitesh Shirsath,Rohit Chaudhari,Avinash More et al.
Nitesh Shirsath et al.
Introduction: Inhalation of drugs for the treatment of pulmonary diseases has been used since a long time. Due to lungs' larger absorptive surface area, delivery of drugs to the lungs is the method of choice for different...
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone [0.03%]
莫西沙星和胺碘酮给药对非临床种属J点至T峰值及T峰值至T波终点间期优化测量的影响
Theresa M Bartko,Stephen M Lutgen,Rebecca A Ross et al.
Theresa M Bartko et al.
Introduction: Cardiovascular safety and the risk of developing the potentially fatal ventricular tachyarrhythmia, Torsades de Pointes (TdP), have long been major concerns of drug development. TdP is associated with a dela...
A simple accurate method for concentration-QTc analysis in preclinical animal models [0.03%]
临床前动物模型中简单精确的浓度-QTc分析方法
Kamila J Sadko,Derek J Leishman,Marc B Bailie et al.
Kamila J Sadko et al.
Introduction: In preclinical cardiovascular safety pharmacology studies, statistical analysis of the rate corrected QT interval (QTc) is the focus for predicting QTc interval changes in the clinic. Modeling of a concentra...
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments [0.03%]
characterization of ascending dose canine telemetry model supports its use in e14/s7b qt integrated risk assessments
Alysia A Chaves,Jude W Ferraro,Jing Yu et al.
Alysia A Chaves et al.
Introduction: Nonclinical evaluation of the cardiovascular effects of novel chemical or biological entities (NCE, NBEs) is crucial for supporting first-in-human clinical trials. One important aspect of these evaluations i...
Haruki Kai,Noriaki Haraoka,Yukio Sugimoto
Haruki Kai
Allergic conjunctival disease is an immune-mediated inflammatory disease of the conjunctiva. To develop clinically useful drugs, it is necessary to develop quantitative evaluation methods that reflect the clinical symptoms in experimental a...
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profiling [0.03%]
鼻内给药包载藤壳素的脂质-聚合物纳米囊的脑组织和脑脊液中藤黄素分析方法的研究及动力学分布研究
Sagar Trivedi,Rishabh Agade,Veena Belgamwar
Sagar Trivedi
Thymoquinone (TH) has been one of the major phytochemical used in the treatment of cancers since long time, especially in the management of glioblastoma multiforme (GBM). The formulation of lipo-polymeric nanoshells (LPNs) and their nasal d...
The rat telemetry assay and venous catheter access buttons for use in cardiovascular safety pharmacology assessments - Surgical methods, refinements and colony maintenance [0.03%]
心血管安全药理学评估中使用的 rat telemetry 植入术和静脉输液港的外科手术方法、改进及种群维护
Ed Hale,Diane Storer,Nastarsia Smith et al.
Ed Hale et al.
Introduction: Rat telemetry is the assay of choice to assess the potential effects of novel drug candidates on cardiovascular parameters during early drug discovery. Telemetry device implantation can be combined with veno...
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry [0.03%]
抗精神病药多巴胺2型、组胺1型和毒蕈碱型乙酰胆碱受体占有率同时测定法的建立与评价液相色谱-串联质谱法
Gaku Akashita,Eriko Nakatani,Shimako Tanaka et al.
Gaku Akashita et al.
Receptor occupancy is an indicator of antipsychotic efficacy and safety. It is desirable to simultaneously determine the occupancy of multiple brain receptors as an indicator of the efficacy and central side effects of antipsychotics becaus...