The emerging use of artificial intelligence in safety pharmacology & toxicology [0.03%]
人工智能在安全药理学和毒理学中的应用不容忽视
Lutfiya Miller,Ian Treleaven,Abdel-Ilah El Amrani et al.
Lutfiya Miller et al.
Safety pharmacology is concerned with the identification and characterization of adverse effects of drug candidates on vital organ systems. The emergence of artificial intelligence (AI) and machine learning (ML) has prompted growing interes...
Detection capabilities of a single dried blood spot for recombinant erythropoietin micro-dose testing in sport [0.03%]
单次干血点检测在体育中用于重组促红细胞生成素微量剂量检测的能力
L Requena-Tutusaus,I Anselmo,S Coll et al.
L Requena-Tutusaus et al.
Objectives: Dried blood spot (DBS) micro-sampling is gaining prominence in anti-doping testing, particularly for the detection of erythropoietin-receptor agonists (ERAs) such as recombinant erythropoietin (rEPO). However,...
Analytical method development for detection and quantification of AMB-FUBINACA in mouse brain tissue using GC-MS/MS [0.03%]
一种用于检测和定量小鼠脑组织中AMB-FUBINACA的气相色谱-质谱联用分析方法的发展研究
Jihad Al-Qudsi,Malak Alghamdi,Abdulsallam Bakdash et al.
Jihad Al-Qudsi et al.
Background and objective: Identifying and quantifying the indazole-derived synthetic cannabinoid, AMB-FUBINACA, in mouse brain tissue is indeed possible. However, evaluating the extraction efficiency, validating the GC-MS...
Simultaneous quantification of venetoclax, busulfan and voriconazole in plasma by LC-MS/MS: Clinical applications in patients with acute myeloid leukemia [0.03%]
血浆中维奈托克、丁脲胺和伏立康唑的LC-MS/MS同时定量分析：在急性髓系白血病患者中的临床应用
Zhenhua Zhang,Bingchen Ge,Yanyu Wang et al.
Zhenhua Zhang et al.
Objective: To develop a novel approach for quantitative analysis of three pharmaceutical agents commonly employed in the treatment of hematological disorders (venetoclax, busulfan, and voriconazole) by liquid chromatograp...
Study on pharmacokinetic behaviors of colchicine sustained-release microspheres in beagle dogs and its relevance to toxicity mitigation via LC-MS/MS [0.03%]
基于LC-MS/MS的秋水仙碱缓释微球在比格犬体内药代行为研究及其减毒增效作用探讨
Chuyao Yang,Jingtao Wang,Qiannan Zhang et al.
Chuyao Yang et al.
Objective: This study aimed to develop a simple and highly sensitive LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) method for quantifying colchicine in beagle plasma and use it to investigate the pharmacokinet...
QbD-based, greenness and whiteness-assessed LC-MS/MS method for simultaneous determination of sodium phenylbutyrate and Taurursodiol with pharmacokinetic application [0.03%]
基于QbD的绿色和白色评估的LC-MS/MS同时测定苯丁酸钠和Taurursodiol的方法及药代动力学应用
Thirumalavasu Palla,Venkata Kanaka Srivani Maddala,Kumaraswamy Gandla
Thirumalavasu Palla
Sodium phenylbutyrate (NaPB) and taurursodiol (TRS) are clinically important agents frequently investigated in combination for therapeutic applications. To facilitate pharmacokinetic studies, a sensitive, robust, and environmentally sustain...
Streamlined dispersive solid phase extraction for determination of amitriptyline, cocaine, and benzoylecgonine in urine [0.03%]
高效液相色谱-质谱法测定尿中阿米替林、可卡因和苯甲基葡萄糖酸酐的方法
Isabela Nucci Galetti,Heloísa Peres Luz,Bruna Espíndola da Silva et al.
Isabela Nucci Galetti et al.
This study aimed to develop and validate an analytical method using dispersive solid phase extraction (d-SPE) with analysis by liquid chromatography coupled with diode array detector (HPLC-DAD). The developed technique showed detection limi...
Rapid quantification of CSF total protein via smartphone digital colorimetry: Enabling early diagnosis of central nervous system diseases [0.03%]
基于智能手机的数字比色法快速定量测定脑脊液总蛋白：早期诊断中枢神经系统疾病的一种手段
Yonghua Zhao,Dandan Liang,Yufei Guo et al.
Yonghua Zhao et al.
Objective: This study evaluated a smartphone-based system for measuring cerebrospinal fluid (CSF) total protein, verifying its compliance with clinical requirements and exploring its application in diagnosing central nerv...
Special Issue of Journal of Pharmacological and Toxicological Methods: Cutting edge pharmacological and toxicological methods [0.03%]
药理和毒理方法杂志特刊：前沿的药理和毒理学方法
Reza Tabrizchi,Noriko Daneshtalab
Reza Tabrizchi
An accurate and reproducible method to measure snake venom anticoagulant activity [0.03%]
一种准确且可重复的测量蛇毒抗凝活性的方法
Kate Murphy,Theo Tasoulis,Geoffrey K Isbister
Kate Murphy
Introduction: Anticoagulant activity is an important clinical effect of human envenoming, seen in Australian black snake (Pseudechis) and cobra (Naja) envenoming. Anticoagulant toxins are not well characterised and antico...