Yarrowia lipolytica, Komagatoella phaffii and secretory proteins: recombinant laccase as a case study [0.03%]
圆褐固氮菌、假酒囊酵母和分泌蛋白：漆酶为例证
Constance Keller,Rocio Cozmar,Miguel Alcalde et al.
Constance Keller et al.
For decades, Komagataella phaffii has been the reference host for recombinant secretory protein (rsProt) production. However, secretion bottlenecks associated with the limited processing capacity of the endoplasmic reticulum restrict the se...
De novo biosynthesis of lavandulol and lavandulyl acetate in Escherichia coli [0.03%]
利用大肠杆菌从头合成香叶烯醇和香叶醇乙酸酯
Kefa Hu,Zhipeng Qi,Xiaode Huang et al.
Kefa Hu et al.
Lavandulol and its acetate ester, lavandulyl acetate, are valuable irregular monoterpenes found in lavender essential oil, widely utilized in the food and cosmetic industries. Due to the limitations of extraction from natural plant resource...
Efficiency and scalability in harvesting mammalian cell cultures: A scale-down approach to continuous centrifugation [0.03%]
哺乳动物细胞培养收获的效率和扩展性：连续离心的规模缩小方法
Michaela Dölle,Maxime Hervé,Staffan Königsson et al.
Michaela Dölle et al.
Continuous centrifugation is a well-established method for clarifying mammalian cell cultures, but traditional batch-based approaches often fall short of modern biomanufacturing's scalability and flexibility demands. Increasing variability ...
Multilevel agro-physiological and biochemical alleviation of salt stress in Olea europaea via phenolic-rich extracts from olive mill waste [0.03%]
富含橄榄果渣提取物的酚类物质多级缓解橄榄树盐胁迫的生理生化机制研究
Samia Abboud,Nada Ammar,Azhar Ouni et al.
Samia Abboud et al.
Soil salinization poses a critical threat to agricultural productivity, particularly in the Mediterranean regions where olive cultivation is of major economic and ecological significance. This study investigates the potential of phenolic ex...
Bispecific Nanobodies - Promising Engineered Candidates with High Therapeutic Efficiency [0.03%]
双特异纳米抗体-高效治疗工程蛋白候选者
Sneha Banerjee,Sreeja Vangapally,Anna Mariya et al.
Sneha Banerjee et al.
Bispecific nanobodies are the emerging class of engineered nanobodies with great scope for targeted therapy due to their small size, high stability, extended half-life, and dual antigenic recognition properties. They can bind to two differe...
Dynamic regulation of ROS stress in the accumulation of L-lysine in Escherichia coli [0.03%]
ROS压力对大肠杆菌中L-赖氨酸积累的动态调节
Li Zhang,Jianan Yang,Zhixuan Lv et al.
Li Zhang et al.
Oxidative stress in E.coli during chemical production, caused by reactive oxygen species (ROS), impairs cell viability and limits output. This study addressed product accumulation and ROS stress in L-lysine-producing strains. Genetic engine...
Antibacterial Nut Grass Cellulose Reinforced Polylactic Acid Nanocomposites: A Holistic Assessment for Biomedical Scaffolds [0.03%]
具有抗菌香附子纤维素增强聚乳酸纳米复合材料的全方位评估以用于生物医学支架
S A Priya,N T Nevaditha
S A Priya
Poly(lactic acid) (PLA) composites reinforced with various natural fibers have been extensively investigated for biomedical applications. However, the use of nut grass-derived cellulose nanofibers (CNFs) remains unexplored in the current li...
Streptomyces bottropensis SY8-derived eumelanin exhibits skin wound healing activity and prevents H2O2 or UV-induced skin aging [0.03%]
黏红菌SY8来源的吴 melanin具有皮肤创伤修复和抗氧化功效
Sevval Yildirim,Buket Bakan,Meryem Doymus et al.
Sevval Yildirim et al.
Streptomyces-derived melanins exhibit diverse bioactive properties. This study aims to (1) produce melanin production from Streptomyces bottropensis SY8 (GenBank accesion number: PQ565816), (2) characterize the melanin, and (3) investigate ...
Integrative Omics Approaches for Bioactive Metabolite Discovery in Marine Macroalgae: Recent Advances and Future Perspectives [0.03%]
整合组学在海洋大型藻类生物活性代谢物发现中的新进展和未来展望
M Marimuthu,M Anitha,P Prakash et al.
M Marimuthu et al.
Phlorotannins, bromophenols, sulfated polysaccharides, terpenoids, lipids and halogenated molecules exhibit potent antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. Conventional discovery methods, such as solvent ext...
Integrative experimental and computational approach for the development of novel plasminogen activators from truncated streptokinase fragments [0.03%]
截短的链激酶片段新型尿激酶促纤溶剂的开发及其整合性实验和计算方法研究
Vijay Gunasekaran,Pichaimuthu Suthakaran,Vigneshwaran Namasivayam et al.
Vijay Gunasekaran et al.
Streptokinase (SK), a widely used thrombolytic agent, activates human plasminogen, which in turn dissolves blood clots. However, its clinical application is limited because it elicits immunogenic responses in patients. The present study aim...