Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis [0.03%]
阿皮金通过抑制NF-κB/HIF-1α介导的糖酵解来削弱细胞干性和DNA损伤修复从而增强小鼠皮下胶质瘤放疗敏感性
Changhao Jia,Ying Zhao,Hui Huang et al.
Changhao Jia et al.
We used radioresistant SU3-5R stem cells-inoculated subcutaneous glioma model to investigate the radiosensitization effect of apigenin. After treatment of glioma with apigenin 20 mg/kg for 12 days, irradiation 8 Gray twice or their combinat...
A comprehensive review on high -fat diet-induced diabetes mellitus: an epigenetic view [0.03%]
高脂饮食诱导糖尿病的表观遗传学研究进展
Monisha Prasad,Ponnulakshmi Rajagopal,Nalini Devarajan et al.
Monisha Prasad et al.
Modern lifestyle, genetics, nutritional overload through high-fat diet attributed prevalence and diabetes outcomes with various complications primarily due to obesity in which energy-dense diets frequently affect metabolic health. One possi...
Isolated and combined impact of dietary olive oil and exercise on markers of health and energy metabolism in female mice [0.03%]
饮食橄榄油和运动对小鼠健康标志物和能量代谢的单独和联合影响
Timothy D Heden,Chen Chen,Grace Leland et al.
Timothy D Heden et al.
An olive oil (OO) rich diet or high-intensity interval training (HIIT) independently improve markers of health and energy metabolism, but it is unknown if combining OO and HIIT synergize to improve these markers. This study characterized th...
Stachydrine derived from fermented rice prevents diet-induced obesity by regulating adipsin and endoplasmic reticulum homeostasis [0.03%]
由发酵大米衍生的天冬氨酰胺通过调节脂质素和内质网稳态防治饮食诱导的肥胖症
Eunjung Lee,Sunhee Kang,Ae-Ran Lee et al.
Eunjung Lee et al.
Makgeolli, a widely consumed traditional alcoholic beverage in Korea, is brewed mainly from rice using Nuruk as a fermentation starter, which contains fungi, yeast, and lactic acid bacteria. Among 58 Makgeolli samples brewed using various N...
Butyrate, a typical product of gut microbiome, affects function of the AhR gene, being a possible agent of crosstalk between gut microbiome, and hepatic drug metabolism [0.03%]
丁酸盐通过影响芳香烃受体基因的功能，可能是肠道菌群与肝脏药物代谢之间的联络因子
Lenka Jourova,Eva Anzenbacherova,Zdenek Dostal et al.
Lenka Jourova et al.
Modulation of gut microbiome composition seems to be a promising therapeutic strategy for a wide range of pathologic states. However, these microbiota-targeted interventions may affect production of microbial metabolites, circulating factor...
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats [0.03%]
花生四烯酸和DHA通过抑制p300-HAT活性缓解大鼠心梗后心力衰竭
Yoichi Sunagawa,Ayumi Katayama,Masafumi Funamoto et al.
Yoichi Sunagawa et al.
While the cardioprotective functions of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-3 unsaturated fatty acids have been previously demonstrated, little is known about their effects on cardiomyocyte hypertrophy. In thi...
Concentration-dependent change in hypothalamic neuronal transcriptome by the dietary fatty acids: oleic and palmitic acids [0.03%]
饮食脂肪酸：油酸和棕榈酸引起下丘脑神经元转录组的浓度依赖性变化
Fabiola Pacheco Valencia,Amanda F Marino,Christos Noutsos et al.
Fabiola Pacheco Valencia et al.
Prenatal high-fat diet exposure increases hypothalamic neurogenesis events in embryos and programs offspring to be obesity-prone. The molecular mechanism involved in these dietary effects of neurogenesis is unknown. This study investigated ...
Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism disease model [0.03%]
补硒可改善氧化应激和炎症并减轻自闭症模型小鼠的自闭症样行为及相关的基因表达
Hongmei Wu,Gang Zhao,Sijin Liu et al.
Hongmei Wu et al.
Autism spectrum disorder (ASD) refers to a group of neurodevelopmental disorders. The etiology and pathological mechanisms of ASD are still unknown, and its prognosis is poor. This study investigated the effects of selenium (Se) supplementa...
Sea cucumber ether-phospholipids improve hepatic steatosis and enhance hypothalamic autophagy in high-fat diet-fed mice [0.03%]
海参醚磷脂改善高脂饮食喂养小鼠的肝脏脂肪变性并提高下丘脑自噬水平
Xiaoxu Wang,Xincen Wang,Peixu Cong et al.
Xiaoxu Wang et al.
As a promising group of natural bioactive lipids, ether-phospholipids (ether-PLs), exhibit the ability to attenuate high-fat diet (HFD)-induced lipid accumulation and atherosclerosis. However, the underlying mechanism is unclear. Autophagy ...
Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts [0.03%]
肿瘤磷脂膜二十碳六烯酸富集增加三阴性乳腺癌患者来源异种移植物小鼠的肿瘤坏死 apoptosis
Marnie Newell,Susan Goruk,Julia Schueler et al.
Marnie Newell et al.
Docosahexaenoic acid (DHA) reduces breast cancer tumor growth in preclinical models. To better understand how DHA amplifies the actions of docetaxel (TXT) chemotherapy, we examined the effects of two doses of dietary DHA on tumor size, memb...