Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets [0.03%]
不同饮食喂养小鼠的肺瘤转移组织和正常肺部组织代谢组学研究
Lin Yan,Sneha Sundaram,Bret M Rust et al.
Lin Yan et al.
Metastasis is a devastating aspect of cancer. This study tested the hypothesis that metabolome of metastases differs from that of host organs by using the spontaneous metastasis model of Lewis lung carcinoma (LLC). In a 2 × 2 design, male ...
Induction of mesenchymal-epithelial transition (MET) by epigallocatechin-3-gallate to reverse epithelial-mesenchymal transition (EMT) in SNAI1-overexpressed renal cells: A potential anti-fibrotic strategy [0.03%]
表没食子儿茶素没食子酸酯诱导mesenchymal-epithelial transition(MET)，逆转SNAI1过表达肾细胞中的上皮间充质转化(EMT)：一种潜在的抗纤维化策略
Rattiyaporn Kanlaya,Chompunoot Kapincharanon,Kedsarin Fong-Ngern et al.
Rattiyaporn Kanlaya et al.
Dynamic transdifferentiation of epithelial cells from epithelial-mesenchymal transition (EMT) to its reverse process, mesenchymal-epithelial transition (MET), has gained wide attention for management of cancers and tissue fibrosis. In this ...
ΔNp63α mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2 [0.03%]
硫代萝卜硫烷通过调节NANOG / OCT4 / SOX2转录抑制结直肠癌干细胞特性中的ΔNp63α介导的作用
Yue Chen,Meng-Huan Wang,Jin-Yi Wu et al.
Yue Chen et al.
Cancer stem cells (CSCs) play a key role in cancer initiation, development, metastasis, and recurrence. Previously, we found that sulforaphane (SFN), a natural compound obtained from cruciferous vegetables, inhibited colorectal CSCs via the...
Amomum subulatum mitigates total body irradiation-induced oxidative stress and its associated inflammatory response by enhancing the antioxidant status and regulating the pro-inflammatory cytokines [0.03%]
豆蘧通过提高抗氧化能力及调节促炎性细胞因子来缓解总照射所致的氧化应激及其相关炎症反应
Sudarsanan Drishya,Suresh Sulekha Dhanisha,Paramu Raghukumar et al.
Sudarsanan Drishya et al.
Free radical-induced oxidative damage and associated inflammatory responses play a crucial role in cancer radiotherapy (RT) mediated normal tissue toxicities. Supplementation of antioxidants or inflammation modulators may alleviate RT toxic...
(-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage [0.03%]
(-)表儿茶素改善BaCl₂损伤CD1鼠腓肠肌修复作用
Magally Ramírez-Ramírez,Francisca Fernández-Valverde,Andrea Reséndiz-García et al.
Magally Ramírez-Ramírez et al.
Several studies have shown the beneficial effect that Epicatechin (Epi) has on the skeletal muscle of murine models and patients with muscular dystrophy and in the muscles of patients with diabetes or murine sarcopenia models. This flavanol...
Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis [0.03%]
缺铁饮食可改变肠道微生物组并在S型伤寒沙门氏菌诱导的肠炎小鼠模型中降低感染严重程度
James R Ippolito,Brian D Piccolo,Michael S Robeson et al.
James R Ippolito et al.
Enteric infections are widespread in infants and children living in low-resource settings. Iron availability in the gastrointestinal tract may modify the gut microbiome and impact the incidence and severity of enteropathy. This study was de...
Corrigendum to 'Raspberry consumption: identification of distinct immune-metabolic response profiles by whole blood transcriptome profiling' [Journal of Nutritional Biochemistry 101C (2022) 108946] [0.03%]
关于“ raspberry消费：通过全血转录组分析识别不同的免疫-代谢反应谱型”[《营养生物化学杂志》101卷C(2022) 108946]的勘误通知
Maximilien Franck,Juan de Toro-Martín,Thibault V Varin et al.
Maximilien Franck et al.
Implementation of a healthy diet to lactating rats attenuates the early detrimental programming effects in the offspring born to obese dams. Putative relationship with milk hormone levels [0.03%]
在肥胖大鼠分娩后代早期实施健康饮食以减轻不良编程效应。可能与母乳激素水平有关
Catalina A Pomar,Pedro Castillo,Mariona Palou et al.
Catalina A Pomar et al.
Lactation is a critical period of development and alterations in milk composition due to maternal diet or status may affect infant growth. We aimed to evaluate in rats whether improving maternal nutrition during lactation attenuates early i...
Bilian Zhu,Honggui Li,Bangchao Lu et al.
Bilian Zhu et al.
Indole is a microbiota metabolite that functions to protect against obesity-associated non-alcoholic fatty liver disease. The present study examined the extent to which indole supplementation alleviates the severity of non-alcoholic steatoh...
Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade [0.03%]
limonin通过上调smad7并随后抑制tgf-β / smad级联反应来缓解体内TGF-β诱导的肝细胞emt和肝星状细胞活化以及小鼠CCl4诱导的肝纤维化
Guangwen Shu,Chenxi Dai,Arslan Yusuf et al.
Guangwen Shu et al.
Liver fibrosis is a pathological process as a result of intrahepatic deposition of excessive ECM. EMT of hepatocytes and activation of HSCs both play important roles in the etiology of liver fibrosis. Here, we found that limonin repressed T...