Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice [0.03%]
烟酸核糖补充剂对雌性饮食诱导的肥胖小鼠具有抗肥胖作用并预防白色脂肪组织中的炎症和纤维化
Mi-Bo Kim,Tho X Pham,Molly vanLuling et al.
Mi-Bo Kim et al.
Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+) precursor. We previously reported that NR supplementation prevented the development of liver fibrosis in male mice. However, whether NR exerts a similar effect in fema...
Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine [0.03%]
人小肠中EGCG及其代谢产物的外排转运蛋白MRP2的研究
Takuya Kikuchi,Akane Hayashi,Naohiro Ikeda et al.
Takuya Kikuchi et al.
Green tea polyphenols have various beneficial effects on human health, such as antiobesity and anti-carcinogenesis. (-)-Epigallocatechin-gallate (EGCG) is one of the major potent green tea catechins; however, detailed mechanisms of EGCG tra...
Long-term consumption of green tea EGCG enhances murine health span by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis, and immunosenescence [0.03%]
长期饮用绿茶儿茶素可改善小鼠健康状况：通过减轻有丝分裂和非有丝分裂组织中的细胞衰老、肠道菌群失调及免疫衰老来实现
Rohit Sharma,Ravi Kumar,Anamika Sharma et al.
Rohit Sharma et al.
Cellular senescence is emerging as a major hallmark of aging, and its modulation presents an effective anti-aging strategy. This study attempted to understand the progression of cellular senescence in vivo, and whether it can be mitigated b...
Antarctic krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota [0.03%]
南极磷虾油通过调节胆汁酸代谢和肠道微生物群来缓解酒精暴露大鼠的肝损伤
Peiyu Guo,Meilan Xue,Xiangyun Teng et al.
Peiyu Guo et al.
Bile acids (BAs) metabolism plays an important role in alcohol liver disease through the gut microflora-bile acids-liver axis. Antarctic Krill Oil (AKO) has protective effects on the liver, while whether AKO can protect against liver injury...
Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats [0.03%]
泡叶藻糖蛋白调节老年雄性大鼠社会隔离引起的PSD95突触聚集改变和认知下降
Jeong Hwan Oh,Youn Hee Choi,Taek-Jeong Nam
Jeong Hwan Oh
Social isolation and loneliness inducing cognitive decline are serious health problems in the elderly. Although the hydrophilic glycoproteins of Capsosiphon fulvescens (Cf-hGP) prevent aging-induced cognitive impairment, its effects on soci...
Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD [0.03%]
花青素通过恢复体外和非酒精性脂肪肝病的临床前模型中的自噬流来减轻氧化损伤、炎症和纤维发生反应
Jyoti Chhimwal,Abhishek Goel,Mahesh Sukapaka et al.
Jyoti Chhimwal et al.
Nonalcoholic fatty liver disease (NAFLD) with growing incidences is a major health concern worldwide. Alteration in cellular redox homeostasis and autophagy plays a critical role in the progression of NAFLD to more severe outcomes. The lack...
CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets [0.03%]
高脂饮食中脂肪酸诱导的骨髓CD4+和CD8+T细胞反应
Mayte Medrano,Ana Lemus-Conejo,Sergio Lopez et al.
Mayte Medrano et al.
Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) that induce obesity have consequences that are currently unclear regarding T-cell maintenance in bone marrow (BM). C...
Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity [0.03%]
烟酰胺通过重新编程脂肪细胞代谢和增加线粒体生物合成来改善肥胖症状
Chengting Luo,Changmei Yang,Xueying Wang et al.
Chengting Luo et al.
Obesity poses a global health challenge and is a major risk factor for diabetes mellitus, cardiovascular diseases, hypertension, stroke and certain kinds of cancers. Although the effects of nicotinamide (NAM) on liver metabolism and disease...
S-adenosylhomocysteine induces cellular senescence in rat aorta vascular smooth muscle cells via NF-κB-SASP pathway [0.03%]
S-腺苷蛋氨酸通过NF-κB-SASP途径诱导大鼠主动脉血管平滑肌细胞衰老
Jiaxin Mi,Xu Chen,You Yiran et al.
Jiaxin Mi et al.
Vascular aging plays an important role in the development and progression of atherosclerosis (AS) , and one-carbon metabolism dysfunction will lead to Vascular Smooth Muscle Cells (VSMCs) senescence, which contributes to vascular senescence...
Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes [0.03%]
果糖通过活性氧介导的机制增强油酸对肝细胞的毒性并导致细胞坏死型凋亡
Jo Kanazawa,Keisuke Kakisaka,Yuji Suzuki et al.
Jo Kanazawa et al.
Non-alcoholic fatty liver disease (NAFLD), the hepatic phenotype of metabolic syndrome, has been identified as a major health concern as the number of cirrhosis and deaths associated with NAFLD is expected to increase. Although fructose int...