Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells [0.03%]
雷帕霉素复合体1信号通路调控蛋白质RPTOR在类肠上皮细胞株Caco-2中的胆固醇代谢作用研究
Bo He,Zhigang Wang,Régis Moreau
Bo He
Although the role of mechanistic target of rapamycin complex 1 (mTORC1) in lipid metabolism has been the subject of previous research, its function in chylomicron production is not known. In this study, we created three stable human colorec...
Effects of starch-rich or fat-rich diets on metabolism, adiposity, and glycemia in immune-biased, C57BL/6 and BALB/c mice [0.03%]
淀粉或脂肪富集饮食对免疫偏倚型、C57BL/6和BALB/c小鼠的代谢、肥胖和血糖的影响
Raktim Mukherjee,Shalini Pandey,Arindam Ghosh et al.
Raktim Mukherjee et al.
Diet maintains health by regulating host metabolism and immunity. The results revealed the consequence of starch-, unsaturated fat-, and saturated fat-rich diets on differentially immune-biased mice C57BL/6 and BALB/c. Time-course of variou...
Effect of a maternal high-fat diet with vegetable substitution on fetal brain transcriptome [0.03%]
蔬菜替代母体高脂肪饮食对胎儿脑转录组的影响
Kate J Claycombe-Larson,Amy N Bundy,Terry Kuntz et al.
Kate J Claycombe-Larson et al.
Maternal dietary conditions play a major role in fetal growth and brain development. The primary aim of this study was to determine the effects of 5% of energy substitution by vegetables in a maternal dietary fat on placental and fetal weig...
Fructose-mediated NLRP3 activation induces inflammation and lipogenesis in adipose tissue [0.03%]
果糖介导的NLRP3活化诱导脂肪组织炎症和脂质生成
Sushmita Singh,Aditya Sharma,Bhavimani Guru et al.
Sushmita Singh et al.
Adipose tissue plays a crucial role in energy intake and regulation of metabolic homeostasis. Fructose consumption implicates in development and progression of metabolic dysfunctions. Fructose is a lipogenic sugar known to induce inflammato...
Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK [0.03%]
α-亚麻酸植烷酸酯通过激活AMPK减轻内质网压力触发的细胞凋亡改善非酒精性脂肪肝病
Hao Han,Tingli Xue,Jie Li et al.
Hao Han et al.
Apoptosis is a feature of progressions steatosis to nonalcoholic steatohepatitis (NASH) and can be explained by endoplasmic reticulum stress (ERS). The present study aimed to investigate the protective effects of plant sterol ester of α-li...
Serum levels of vitamin A, selenium, and better dietary total antioxidant capacity are related to lower oxidative DNA damage: A cross-sectional study of individuals at cardiovascular risk [0.03%]
血清维生素A、硒和更好的饮食总抗氧化能力与较低的氧化性DNA损伤相关：一项针对心血管疾病高危个体的横断面研究
Sílvia Regina de Lima-Reis,Thamires Aguiar Silva,Letícia Sayuri Adama Costa et al.
Sílvia Regina de Lima-Reis et al.
The risk for cardiovascular diseases (CVR) has been associated with oxidative DNA damage, but the genetic and environmental factors involved in the antioxidant and DNA repair system contributing to this damage are unknown. The aim was to ev...
Opisthorchis viverrini infection induces metabolic disturbances in hamsters fed with high fat/high fructose diets: Implications for liver and kidney pathologies [0.03%]
Opisthorchis viverrini感染可诱导高脂/高果糖饮食地鼠代谢紊乱：对肝肾病理的影响
Ornuma Haonon,Zhigang Liu,Rungtiwa Dangtakot et al.
Ornuma Haonon et al.
A combination of Opisthorchis viverrini infection and high fat/high fructose diets (HFa/HFr) intake is likely to enhance fatty liver and kidney pathologies. Here we investigated the combined effects of chronic O. viverrini infection and HFa...
Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux [0.03%]
芦丁通过恢复溶酶体功能和自噬流来保护棕榈酸诱导的胰岛β细胞凋亡
Hao Liu,Wenling Zhou,Lan Guo et al.
Hao Liu et al.
Quercetin, a natural flavonoid, has been reported to prevent pancreatic β-cell apoptosis in animal models of diabetes. However, the underlying mechanism remains unclear. We investigated the mechanisms through which quercetin protects β ce...
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling [0.03%]
运动通过SESN2/AMPKα1/HIF-1α信号保护高脂饮食引起的肠上皮屏障功能障碍
Chunxia Yu,Sujuan Liu,Yanmei Niu et al.
Chunxia Yu et al.
Over-nutrition and a sedentary lifestyle are associated with increased intestinal permeability. This condition promotes obesity and associated metabolic disorders. Sestrin2 (SESN2) is a stress-inducible protein thought to promote the surviv...
Alteration of sweet taste receptor expression in circumvallate papillae of mice with decreased sweet taste preference induced by social defeat stress [0.03%]
社会挫败压力导致小鼠甜味偏好的降低与轮廓乳头中甜味受体表达的改变有关
Yuka Takahata,Waka Yoshimoto,Eri Kuwagaki et al.
Yuka Takahata et al.
Anhedonia is a key diagnostic symptom and central feature of depression symptomatology, but the underlying mechanism remains unknown. In this study, we investigated whether the decrease of sweet taste preference, anhedonia-like behavior in ...