High-fat diet alleviates colitis by inhibiting ferroptosis via solute carrier family seven member 11 [0.03%]
高脂饮食通过溶质载体家族7成员11抑制铁死亡从而缓解结肠炎
Xiaoli Zhang,Yiming Ma,Jiafu Ji et al.
Xiaoli Zhang et al.
A high-fat diet (HFD) is reported to exacerbate ulcerative colitis by inducing obesity, which conceals the effect of the diet itself. Ferroptosis, a type of regulated cell death induced by lipid hydroperoxides, has recently been reported in...
Vitamin D boosts immune response of macrophages through a regulatory network of microRNAs and mRNAs [0.03%]
维生素D通过microRNA和mRNA的调控网络增强巨噬细胞免疫反应
Geysson Javier Fernandez,Julieta M Ramírez-Mejía,Silvio Urcuqui-Inchima
Geysson Javier Fernandez
Vitamin D is associated with the stimulation of innate immunity, inflammation, and host defense against pathogens. Macrophages express receptors of Vitamin D, regulating the transcription of genes related to immune processes. However, the t...
Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice [0.03%]
遗传多样化的协作杂交小鼠中由饮食诱导的非酒精性脂肪肝病的肝脏酯化脂肪酸脂质组学分析
Suresh K Nagumalli,Rose A Willett,Aline de Conti et al.
Suresh K Nagumalli et al.
Non-alcoholic fatty liver disease (NAFLD), one of the most common forms of chronic liver disease, is characterized by the excessive accumulation of lipid species in hepatocytes. Recent studies have indicated that in addition to the total li...
N-3 polyunsaturated fatty acids block the trimethylamine-N-oxide- ACE2- TMPRSS2 cascade to inhibit the infection of human endothelial progenitor cells by SARS-CoV-2 [0.03%]
n-3多不饱和脂肪酸通过阻断三甲胺-n-氧化物-ACE2-TMPRSS2级联反应来抑制SARS-CoV-2感染人内皮祖细胞
En-Pei Isabel Chiang,Jia-Ning Syu,Hung-Chang Hung et al.
En-Pei Isabel Chiang et al.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is a novel coronavirus that infects many types of cells and causes cytokine storms, excessive inflammation, acute respiratory distress to induce failure of respiratory system and o...
Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring [0.03%]
母体摄入硫代葡萄糖苷对后代肠道微生物的长期有益作用
Yan Wei,Lijia Chang,Guoqi Liu et al.
Yan Wei et al.
Mounting evidence suggests the impact of maternal diet on the health of offspring. We reported that maternal diet of sulforaphane glucosinolate (SGS) could prevent behavioral abnormalities in offspring after maternal immune activation. The ...
Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis via modulating gut microbiota dysbiosis and related gut-liver axis activation in CD-1 mice [0.03%]
姜黄素通过调节肠道微生物群紊乱和相关肠肝轴活化防治双酚A致小鼠肝脏脂变作用的研究
Ting Hong,Xin Jiang,Jun Zou et al.
Ting Hong et al.
Chronic exposure to low-dose bisphenol A (BPA) has become a global problem of public health. Our previous work showed that low-dose BPA exposure caused gut microbial dysbiosis and hepatic steatosis. Curcumin, a polyphenol extracted from tur...
Low protein diet during lactation programs hepatic metabolism in adult male and female rats [0.03%]
泌乳期低蛋白饮食可编程成年大鼠肝脏代谢性别差异
Iala Milene Bertasso,Egberto Gaspar de Moura,Carla Bruna Pietrobon et al.
Iala Milene Bertasso et al.
The liver is an essential regulator of energy metabolism, and its function can be disrupted by nutritional alterations. Since liver development continues during breastfeeding nutritional challenges during this period predispose patients to ...
Glucose enrichment impair neurotransmission and induce Aβ oligomerization that cannot be reversed by manipulating O-β-GlcNAcylation in the C. elegans model of Alzheimer's disease [0.03%]
葡萄糖富集影响神经传递并诱导阿尔茨海默病线虫模型中Aβ寡聚化，且不能通过操纵O-GlcNAc转移酶来逆转该过程
Waqar Ahmad
Waqar Ahmad
Amyloid beta (Aβ) plaques formation and impaired neurotransmission and neuronal behaviors are primary hallmarks of Alzheimer's disease (AD) that are further associated with impaired glucose metabolism in elderly AD's patients. However, the...
Ascorbic acid promotes nucleus pulposus cell regeneration by regulating proliferation during intervertebral disc degeneration [0.03%]
抗坏血酸通过调节细胞增殖促进椎间盘退变过程中髓核细胞再生
Yu-Yang Yi,Shu-Bao Zhang,Hao Chen et al.
Yu-Yang Yi et al.
Intervertebral disc degeneration (IVDD) affects human health. Ascorbic acid (AA) deficiency is a major factor that contributes to the development of degenerative disc disease in the elderly. Here, as a novel treatment with promising applica...
EGCG and catechin relative to green tea extract differentially modulate the gut microbial metabolome and liver metabolome to prevent obesity in mice fed a high-fat diet [0.03%]
儿茶素和表没食子儿茶素相对于绿茶提取物通过差异化调节肠道微生物代谢组和肝脏代谢组来预防高脂饮食小鼠肥胖的作用机制
Xiaowei Sun,Priyankar Dey,Richard S Bruno et al.
Xiaowei Sun et al.
Green tea extract (GTE) alleviates obesity, in part, by modulating gut microbial composition and metabolism. However, direct evidence regarding the catechin-specific bioactivities that are responsible for these benefits remain unclear. The ...