Gallic acid ameliorates atherosclerosis and vascular senescence and remodels the microbiome in a sex-dependent manner in ApoE-/- mice [0.03%]
没食子酸通过性别依赖性方式改善Apoe基因敲除小鼠的动脉粥样硬化和血管衰老并重塑其微生物群
McKenzie Clark,Ann M Centner,Vladimir Ukhanov et al.
McKenzie Clark et al.
Polyphenols found in fruits and vegetables are associated with a reduced incidence of cardiovascular disease (CVD), the leading cause of death in the USA. Our lab demonstrated that blackberry supplementation reduces atherosclerosis in male,...
Intermittent fasting attenuates lipopolysaccharide-induced acute lung injury in mice by modulating macrophage polarization [0.03%]
间歇性断食通过调节巨噬细胞极化减轻脂多糖诱导的小鼠急性肺损伤
Li Ma,Yan-Qing Chen,Zhi-Jian You et al.
Li Ma et al.
Acute lung injury (ALI) is a spectrum of acute and life-threatening pulmonary inflammatory conditions. Treatment of ALI remains a clinical challenge. Recently, intermittent fasting (IF) has been shown to improve health and alleviate many di...
Transgenerational effects of zinc, selenium and chromium supplementation on glucose homeostasis in female offspring of gestational diabetes rats [0.03%]
妊娠糖尿病大鼠子代雌性后代锌、硒和铬补充剂的跨世代效应对其糖代谢的影响
Xueqiong Yao,Shanshan Huang,Yan Li et al.
Xueqiong Yao et al.
Clinical studies have demonstrated that maternal gestational diabetes mellitus (GDM) increases the offspring's risk of developing glucose intolerance. Our previous study reported that co-supplementation with zinc, selenium, and chromium imp...
Vitamin-D ameliorates sepsis-induced acute lung injury via augmenting miR-149-5p and downregulating ER stress [0.03%]
维生素D通过增加miR-149-5p和下调ER应激来改善脓毒症诱导的急性肺损伤
Shaniya Ahmad,Almaz Zaki,Kailash Manda et al.
Shaniya Ahmad et al.
Acute lung injury is a life-threatening medical problem induced by sepsis or endotoxins and may be associated with enhanced Endoplasmic reticulum stress (ER stress). Vitamin-D (Vit-D) possesses an anti-inflammatory effect; however, this spe...
12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation [0.03%]
12-氧代奥乐欣醇是橄榄油的成分之一，可减轻肥胖引起的炎症
Knowledge Mudhibadhi Moyo,Jieun Choi,Jiyeon Chang et al.
Knowledge Mudhibadhi Moyo et al.
Fatty acid esters of hydroxyl fatty acids (FAHFAs) are a new family of endogenous lipids that exert anti-inflammatory action. Among the various FAHFA isomers, the dietary source of oleic acid-hydroxy stearic acid (OAHSA) and its anti-inflam...
Functional fiber enhances the effect of every-other-day fasting on insulin sensitivity by regulating the gut microecosystem [0.03%]
功能纤维通过调节肠道微生态增强间歇性限时进食对胰岛素敏感性的改善作用
Jianwei Gao,Chuanhui Xu,Mengdi Zhang et al.
Jianwei Gao et al.
Every-other-day fasting (EODF), which involves alternating days of fasting and feeding, has been reported to lower obesity, and dietary fibers can improve metabolism by altering gut microbiota. This study investigated whether the combinatio...
Time-restricted feeding rescues circadian disruption-aggravated progression of Alzheimer's disease in diabetic mice [0.03%]
限时进食缓解糖尿病小鼠阿尔茨海默病昼夜节律紊乱恶化现象研究
Xuemin Peng,Rongping Fan,Lei Xie et al.
Xuemin Peng et al.
Circadian rhythms, type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are closely related and interacted with each other. We have previously showed circadian disruption aggravated progression of AD in T2DM mice. Time-restricted fe...
Combined caloric restriction and exercise provides greater metabolic and neurocognitive benefits than either as a monotherapy in obesity with or without estrogen deprivation [0.03%]
联合限制卡路里和运动比单一治疗更能提供更大的代谢和神经认知效益以应对肥胖症（伴有或不伴随雌激素缺乏）
Wasana Pratchayasakul,Busarin Arunsak,Kanokphong Suparan et al.
Wasana Pratchayasakul et al.
Neurodegeneration, as indicated by brain dysfunction and cognitive decline, is one of the complications associated with obesity and estrogen deprivation. Calorie restriction and exercise regimes improved brain function in neurodegenerative ...
Vitamin E functions by association with a novel binding site on the 67 kDa laminin receptor activating diacylglycerol kinase [0.03%]
维生素E通过与67kD层粘连蛋白受体上的新结合位点相互作用激活二酰基甘油激酶发挥作用
Daiki Hayashi,Varnavas D Mouchlis,Seika Okamoto et al.
Daiki Hayashi et al.
It is generally recognized that the main function of α-tocopherol (αToc), which is the most active form of vitamin E, is its antioxidant effect, while non-antioxidant effects have also been reported. We previously found that αToc amelior...
Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European Whites: findings from comparative two-stage genome-wide association studies [0.03%]
台湾汉人和欧洲白人的血红蛋白浓度的共有及特有遗传决定因素：基于两阶段全基因组关联研究结果的发现
Vanessa Joy Timoteo,Kuang-Mao Chiang,Hsin-Chou Yang et al.
Vanessa Joy Timoteo et al.
Human iron nutrition is a result of interplays between genetic and environmental factors. However, there has been scarcity of data on the genetic variants associated with altered iron homeostasis and ethnic-specific associations are further...