(-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity [0.03%]
(-)-表儿茶素通过小鼠模型缓解高脂饮食诱导的肥胖相关焦虑行为
Jiye Kang,Ziwei Wang,Eleonora Cremonini et al.
Jiye Kang et al.
Mounting evidence demonstrates that consumption of high fat diet (HFD) and subsequent development of obesity leads to alterations in cognition and mood. While obesity can affect brain function, consumption of select dietary bioactives may h...
Short-term exposure of HFD depresses intestinal cholinergic anti-inflammatory activity through hypothalamic inflammation in mice [0.03%]
短期高脂肪饮食通过下丘脑炎症抑制小鼠肠胆碱抗炎作用
Huiying Liu,Limei Hu,Lijuan Zuo et al.
Huiying Liu et al.
High-fat diet (HFD) exposure has been proven to impair vagus nerve function. However, it is not yet known whether the HFD challenge impacts vagal efferent-based intestinal cholinergic anti-inflammation activity. This investigation aims to e...
Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria [0.03%]
番茄红素通过FGF21和线粒体介导的机制减轻氧化应激诱导的胰岛素信号转导障碍及肝功能损伤
Jia Wang,Ting Li,Mengling Li et al.
Jia Wang et al.
Lycopene (LYC) has been regarded as a nutraceutical that has powerful antioxidant and hepatoprotective bioactivities. In the present study, we aimed to investigate the beneficial effects of LYC on hepatic insulin signal transduction under o...
Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update [0.03%]
可食用类黄酮的尿酸氧化酶抑制和抗癌化疗性能之间的相互作用-全面更新
Md Sohanur Rahaman,Md Afjalus Siraj,Md Arman Islam et al.
Md Sohanur Rahaman et al.
Gout is an inflammatory disease caused by metabolic disorder or genetic inheritance. People throughout the world are strongly dependent on ethnomedicine for the treatment of gout and some receive satisfactory curative treatment. The natural...
Alternate-day fasting prevents non-alcoholic fatty liver disease and working memory impairment in diet-induced obese mice [0.03%]
隔日断食可防止饮食诱导的肥胖小鼠发生非酒精性脂肪肝和工作记忆减退
Wentong Zhang,Jun Wang,Luanfeng Wang et al.
Wentong Zhang et al.
Alternate-day fasting (ADF) regimen has been reported to alleviate obesity and insulin resistance. However, the effects of ADF on preventing diet-induced non-alcoholic fatty liver disease (NAFLD) and related cognitive deficits are still elu...
Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation [0.03%]
大豆异黄酮通过调节氧化应激和卵巢炎症改善母猪繁殖力
Kunhong Xie,Yan Li,Guoru He et al.
Kunhong Xie et al.
Adequate ovarian hormones secretion is essential for pregnancy success. Oxidative damage and following inflammation can destroy the ovarian normal function in mammals. Daidzein (DAI) is a classical isoflavonic phytoestrogen with specific oe...
Vitamin D protects silica particles induced lung injury by promoting macrophage polarization in a KLF4-STAT6 manner [0.03%]
维生素D通过促进KLF4-STAT6途径的巨噬细胞极化来预防硅尘诱导的肺损伤
Youjing Yang,Shuhui Wei,Qianmin Li et al.
Youjing Yang et al.
Silicosis is one of the severest occupational diseases worldwide, manifesting as infiltration of inflammatory cells, excessive secretion of pro-inflammatory mediators and pulmonary diffuse fibrosis. Macrophages polarization to M2 is one of ...
Quercetin supplementation attenuates cisplatin induced myelosuppression in mice through regulation of hematopoietic growth factors and hematopoietic inhibitory factors [0.03%]
檞皮素通过调节造血生长因子和造血抑制因子来缓解白金诱导的小鼠骨髓抑制作用
Cheng-Hung Chuang,Yi-Chin Lin,Jung Yang et al.
Cheng-Hung Chuang et al.
The present study investigated the effects of quercetin on cisplatin (CDDP)-induced common side effect, myelosuppression, and the possible mechanisms in Balb/c mice. The mice were randomly treated with CDDP alone or in combination with quer...
(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells [0.03%]
(-)-表儿茶素及其结肠代谢产物hippuric acid对糖皮质激素引起的骨骼肌萎缩具有保护作用
Sophie J Edwards,Steven Carter,Thomas Nicholson et al.
Sophie J Edwards et al.
Cocoa flavanols have been shown to improve muscle function and may offer a novel approach to protect against muscle atrophy. Hippuric acid (HA) is a colonic metabolite of (-)-epicatechin (EPI), the primary bioactive compound of cocoa, and m...
Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate [0.03%]
表没食子儿茶素没食子酸酯有效对抗rhabdomyolysis诱导的急性肾损伤及ROS介导的内质网应激引起的细胞凋零作用
Sukkum Ngullie Chang,Muhammad Haroon,Debasish Kumar Dey et al.
Sukkum Ngullie Chang et al.
Rhabdomyolysis induced acute kidney injury (RIAKI) is a life-threatening condition responsible for approximately 19-58% of AKI cases worldwide. We performed an intramuscular injection of glycerol (10 mL/kg) in male wistar rats to induce AKI...