Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis [0.03%]
基于双向孟德尔随机化和转录组分析的血浆代谢物与肌少症及衰老表型的遗传预测关联图谱研究
Qijun Wang,Shibao Lu
Qijun Wang
Observational studies have demonstrated associations between plasma metabolites and sarcopenia/aging. This study aimed to investigate the genetically predicted associations between plasma metabolites and sarcopenia/aging traits and to disco...
Oligomeric Peptides LLRLTDL and GYALPCDCL Alleviate Obesity Through HO-1/Nrf2-Dependent Pathways in High Fat Diet-Induced Mice [0.03%]
寡肽LLRLTDL和GYALPCDCL通过HO-1/Nrf2信号通路缓解高脂饮食诱导的小鼠肥胖症状
Chathuri Kaushalya Marasinghe,Lakshi Ayodya Dayarathne,Indyaswan Tegar Suryaningtyas et al.
Chathuri Kaushalya Marasinghe et al.
The potential anti-obesity, anti-inflammatory, and anti-oxidative stress properties of ark shell-derived LLRLTDL (Bu1) and GYALPCDCL (Bu2) peptides were comprehensively investigated. In bone marrow-derived mesenchymal stem cells (BMMSCs), b...
Quercetin alleviates atherosclerosis associated with reduced lysophosphatidylcholine-induced macrophage extracellular traps formation and modulation of the JNK/Sp1/PAD4 pathway [0.03%]
染料木素通过减少溶血磷脂酰胆碱诱导的巨噬细胞胞外陷阱形成及调节JNK/Sp1/PAD4通路来缓解动脉粥样硬化
Na Liang,Linyao Ying,Xin Huang et al.
Na Liang et al.
Macrophage extracellular traps (METs) are reticular structures released by macrophages that contribute to inflammatory responses. Excessive formation and accumulation of METs have been implicated in the progression of atherosclerosis (AS). ...
Replacing red meat with non-soy legumes alters choline metabolites but not systemic inflammation or proxies of gut barrier function in healthy males in a 6-week RCT [0.03%]
以非大豆豆类替代红肉可以改变育龄女性中的胆碱代谢物但不能改变系统性炎症或肠道屏障功能的标志物：一项为期6周的随机对照试验结果
Tuulia K Pietilä,Elisabetta Cantini,Suvi T Itkonen et al.
Tuulia K Pietilä et al.
While the health burden of high red and processed meat intake has been acknowledged in observational studies, studying the effects and mechanisms in controlled settings with healthy participants have generated mixed findings. We aimed to in...
Intestinal epithelial peroxisome proliferator-activated receptor γ deficiency exacerbates insulin resistance in mice with metabolic dysfunction-associated steatohepatitis [0.03%]
肠上皮过氧化物酶增殖激活受体γ缺乏通过加重代谢功能异常相关脂肪肝病小鼠的胰岛素抵抗促进疾病进展
Yun-Cheng Hsieh,Bernd Schnabl,Yi-Hsiang Huang et al.
Yun-Cheng Hsieh et al.
Background: Peroxisome proliferator-activated receptor γ (PPARγ) is highly expressed in the intestinal epithelium and protects against intestinal inflammation. Intestinal inflammation and bacterial translocation contrib...
Tracing Oxidative Metabolism: [¹¹C]Acetate-PET with Radiometabolite Correction Reveals Early Hepatic Metabolic Alterations in the Diet-Induced MAFLD Model [0.03%]
追踪氧化代谢：[¹¹C]乙酸-PET结合放射性代射物校正揭示了饮食诱导的MAFLD模型早期肝代谢变化
Usevalad Ustsinau,Marius Ozenil,Antonia Grosinger et al.
Usevalad Ustsinau et al.
[¹¹C]Acetate-PET, widely applied in cardiology and oncology, offers unique potential as a non-invasive imaging method for assessing oxidative metabolism in metabolic disorders. In this study, we investigated its ability to detect early me...
α-linolenic acid-rich diet boosts docosahexaenoic acid levels and restores lipid balance in the brain parenchyma and vasculature of APOE4 mice [0.03%]
富含α亚麻酸饮食可增加apoE4小鼠脑实质和血管中二十碳六烯酸水平并恢复脂质稳态
Alicia Leikin-Frenkel,Orly Ravid,Meir Liberman et al.
Alicia Leikin-Frenkel et al.
The APOE4 allele significantly increases Alzheimer's disease (AD) risk, often linked to brain lipid imbalance. This study investigated lipid profiles in the brain parenchyma and brain blood vessels (BBV) of APOE3 and APOE4-humanized female ...
Novel mechanisms of dietary folic acid in improving hepatopancreas health of grass carp (Ctenopharyngodon idellus): the perspectives of autophagy and DNA methylation [0.03%]
膳食叶酸改善草鱼肝胰脏健康的新型机制：自噬和DNA甲基化的视角
Yun Wang,Lin Feng,Wei- Dan Jiang et al.
Yun Wang et al.
B vitamins play an important role in improving lipid and glucose metabolism in fish, but there remains a lack of systematic and in-depth research on the effects of folic acid (FA) on lipid and glucose metabolism in the hepatopancreas of fis...
Distinct Mechanistic Pathways in Mouse MASLD Models: High-Sucrose/Starch Versus High-Fat, Methionine- and Choline-Deficient Diets [0.03%]
小鼠MASLD模型中高蔗糖/淀粉与高脂以及甲硫氨酸和胆碱缺乏性饮食的区别性发病机制途径研究
Yanzhe Xu,Yun Zhu,Kyuhong Lee et al.
Yanzhe Xu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from simple steatosis (MASL) to fibrotic steatohepatitis (MASH). Yet, the molecular mechanisms initiating these divergent outcomes remain unclear. We addressed the ques...
Prenatal and Postnatal Choline Supplementation Alters Metabolic Dysfunction-Associated Steatohepatitis (MASH) Phenotypes in Offspring Exposed to Maternal Obesity and Following a Western Diet into Adulthood: a Preliminary Study [0.03%]
母体肥胖暴露和成年后西方饮食诱导的代谢紊乱相关肝炎(MASH)小鼠后代中，产前及产后胆碱补充对MASH表型的影响：初步研究
Hunter W Korsmo,Hrutvik Bhavsar,Steven Trasino et al.
Hunter W Korsmo et al.
We previously demonstrated that prenatal choline supplementation (CS) mitigates metabolic abnormalities in mouse offspring exposed to maternal obesity. In this preliminary study we examined whether prenatal and postnatal CS can protect agai...