Bacteroides thetaiotaomicron and Bacteroides ovatus for the Treatment of MAFLD: A Comparative Study of Individual and Combined Effects [0.03%]
芽孢杆菌thetaiotamicron和芽孢杆菌ovatus治疗MAFLD的个体及联合作用比较研究
Xiuxia Li,Guangpeng Zhou,Changrui Sun et al.
Xiuxia Li et al.
Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing global health concern linked to gut microbiota dysbiosis. This study aims to evaluate the therapeutic effects of Bacteroidetes on MAFLD,...
Sustained High-Fat Diet Intake Differentially Regulates Hepatic Lipophagy and Metabolic Adaptation after Bariatric Surgery in Obese Rats [0.03%]
高脂饮食通过调控肥胖大鼠胆囊切除术后的肝脂自噬而影响代谢适应性
Shih-Yi Huang,Chen-Yu Liao,Ching-Wen Chang et al.
Shih-Yi Huang et al.
The global rise in obesity has been paralleled by an increasing burden of metabolic dysfunction-associated steatotic liver disease (MASLD). This study examined how metabolic bariatric surgery, sleeve gastrectomy (SG), under continued exposu...
Multi-omics reveals that chenodeoxycholic acid promotes calcium oxalate kidney stone formation by targeting catalase [0.03%]
多组学揭示鹅去氧胆酸通过靶向过氧化氢酶促进草酸钙肾结石形成
Yingchun Liang,Shuxin Si,Ruicheng Gao et al.
Yingchun Liang et al.
The aim of this study was to investigate the key bile acid metabolites and the target of action during calcium oxalate (CaOx) kidney stone formation using a multi-omics approach. CaOx kidney stone models in Sprague-Dawley (SD) rats were est...
PRC1 promotes MAFLD progression by regulating glycolysis/lactylation axis and forming a positive feedback loop [0.03%]
PRC1通过调节糖酵解/乳酸化轴并形成正反馈环促进MAFLD进展
Xinlei Zou,Nan Wang,Canghai Guan et al.
Xinlei Zou et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD), a globally prevalent liver disorder with rising incidence, carries significant risks of progression to end-stage conditions like liver fibrosis and hepatocellular carcinoma. Glyc...
Bacterial dynamics govern growth trajectories and choline-derived trimethylamine production [0.03%]
细菌动力学决定生长轨迹和胆碱衍生三甲胺的产生
Justin Tang,Andre D Boudreau,Jacob A Bryan et al.
Justin Tang et al.
Dietary choline is converted by gut bacteria into trimethylamine (TMA), the precursor of the pro-atherogenic molecule trimethylamine-N-oxide (TMAO). Circulating TMAO levels vary widely across individuals, yet the bacterial interactions and ...
Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes [0.03%]
无论APOE基因型如何 LPC-n-3补充剂可显著增加小鼠大脑EPA水平但仅携带apoE3等位基因的小鼠出现DHA水平的特异性增加
Bijou Andriambelo,Annick Vachon,Marc-André Dansereau et al.
Bijou Andriambelo et al.
Background: In a previous study, we showed that oral supplementation with lysophosphatidylcholine (LPC)-bound omega-3 fatty acids (n-3) increases cortical eicosapentaenoic acid (EPA, C20:5n-3) but not docosahexaenoic acid...
Small litter size attenuates adverse hepatic effects induced by a high-sucrose diet [0.03%]
小窝仔数可减轻高蔗糖饮食诱导的肝脏不良影响
Juliana Letícia Silva,Isabela Jesus de Deus,Aline Rezende Ribeiro de Abreu et al.
Juliana Letícia Silva et al.
We evaluated whether metabolic imprinting (MI) induced by small litter size (SL) could mitigate liver damage, redox imbalance, and NLRP3 inflammasome activation caused by a high-sucrose diet (HSD) in young rats. Male Wistar rats (P0) were d...
Dietary Advanced Glycation End Products Induced Anxiety- and Depression-like Behaviors in Female C57BL/6 Mice and the Ameliorative Effects of Quercetin [0.03%]
饮食晚期糖基化终产物诱导C57BL/6雌鼠焦虑和抑郁样行为及芸香素的改善作用
Tongtong Ma,Zhilong He,Guoqi Yang et al.
Tongtong Ma et al.
Quercetin is a flavonoid bioactive compound with potential anti-depression effect. Dietary advanced glycation end products (AGEs) might be critically associated with depression. We aimed to explore whether quercetin ameliorates dietary AGEs...
From Intestine to Liver: A Review of the Pathological Mechanisms of Ulcerative Colitis-Induced Secondary Liver Injury and Targeted Therapies with Medicinal [0.03%]
从肠道到肝脏：溃疡性结肠炎继发肝损伤的病理机制及中药靶向治疗研究综述
Jing Zhou,Xuanying Xin,Yan Wang
Jing Zhou
This review systematically integrates the multi-level pathological mechanisms of the gut-liver axis in ulcerative colitis (UC)-secondary liver injury (SLI) and the multi-target intervention network of natural bioactive compounds, elucidatin...
Placental vitamin D malnutrition induced by vitamin D deficiency during pregnancy causes placenta dysplasia by regulating GSK-3β/β-catenin and CD44 as well as interfering their feedback interaction in rats [0.03%]
维生素D缺乏导致胎盘维生素D营养不良通过调节GSK-3β/β-连环蛋白和CD44以及干扰它们的反馈相互作用诱导大鼠胎盘发育不良
Yu Han,Xiaoxia Sun,Yu Qiao et al.
Yu Han et al.
Vitamin D deficiency (VDD) is highly prevalent during pregnancy, which can lead to poor placental development and functional abnormalities, and may trigger a series of pregnancy-related diseases in severe cases. The Wnt/β-catenin signallin...