Forsythiaside A attenuates intervertebral disc degeneration by suppressing PI3K/AKT/NF-κB-mediated NLRP3 inflammasome activation and pyroptosis [0.03%]
山银花黄素A通过抑制PI3K/Akt/NF-κB介导的NLRP3炎性小体活化和细胞焦亡来缓解椎间盘退变
Jun Xuan,Jianyuan Gao,Xiangyang Wang et al.
Jun Xuan et al.
Background: Intervertebral disc degeneration (IVDD) is a major cause of low back pain, characterized by inflammatory responses and NLRP3 inflammasome-driven pyroptosis. Forsythiaside A (FTA), a primary bioactive compound ...
Targeting Autophagy and UPR in NAFLD-Induced Renal Injury: The Role of Chlorella vulgaris and Lactobacillus casei [0.03%]
小球藻和干酪乳杆菌靶向自噬和未折叠蛋白反应在非酒精性脂肪肝病诱导的肾损伤中的作用
Atefeh Raoofat,Mojtaba Jafarinia,Sanaz Dastghaib
Atefeh Raoofat
Background: Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a contributor to renal injury through mechanisms involving oxidative stress, inflammation, and cellular stress pathways. This study aimed...
Reduced interleukin-2 production and increased CREMα protein expression in vegetarians and vegans due to zinc deficiency [0.03%]
由于锌缺乏素食者和纯素食者体内白细胞介素-2生成减少以及CREMα蛋白表达增加
Martina Maywald,Klara Marie Schmitt,Jens Bertram et al.
Martina Maywald et al.
Nutrition is a key determinant of health and may be regarded as a form of preventive medicine, as an adequate supply of vitamins, fats, proteins, and trace elements is essential for proper immune function. In recent decades vegetarian and v...
Microbial-derived Mediators of the Gut-Brain Axis: Implications for Neurological Disorders [0.03%]
肠道微生物介导的肠脑轴与神经疾病的关系研究进展
Mariam M Abady,Amal M Shawky,Dina Mostafa Mohammed
Mariam M Abady
Gut-brain communication is mediated by metabolic and signaling pathways that play important roles in brain development and cognitive function. Recently, the bidirectional role of the gut microbiota in the Gut-Brain axis has drawn greater sc...
Leptin Mediates the Effects of Sulfur Amino Acid Restriction on Food Intake and Body Weight in Mice [0.03%]
蛋氨酸限制通过瘦素调控小鼠的食物摄入和体重下降现象
Diana Cooke,Amadou Ouattara,Gene P Ables
Diana Cooke
Sulfur amino acid restriction (SAAR) paradoxically increases food intake while inducing weight loss, but the mechanisms underlying these outcomes remain unclear. To investigate the role of leptin in this response, we assessed food intake, b...
L-Theanine Activates the mTOR Signaling Pathway through TAS1R1-FRMD6 To Promote Milk Synthesis in Bovine Mammary Epithelial Cells [0.03%]
L-茶氨酸通过TAS1R1-FRMD6激活mTOR信号通路促进牛乳腺上皮细胞乳汁合成
Xiechen Zhou,Mingyang Sun,Naiyuan Jiang et al.
Xiechen Zhou et al.
L-Theanine (LT), a characteristic amino acid found in tea, possesses diverse biological activities, including antioxidant, growth-promoting, and immune-enhancing effects, and is widely used in supplements. However, the regulatory role of LT...
Association between maternal obesity and neonatal folate and vitamin B12 status: functional biomarkers and placental transporters [0.03%]
母体肥胖与新生儿叶酸和维生素B12状态之间的关系：功能生物标志物和平滑肌转运蛋白
Erika Castaño-Moreno,Karina Carrasco-Negue,Rocío Díaz de la Garza et al.
Erika Castaño-Moreno et al.
Background: Pregestational obesity increases the risk of vitamin deficiencies in mothers, yet its impact on neonatal status and placental transporters is unclear. This study investigates the association between pregestati...
Niacin enhances erythropoiesis and attenuates oxidative stress and ferroptosis through the modulation of Nrf2/HO-1/GPX4 pathway in phenylhydrazine-induced hemolytic anemia in rats [0.03%]
烟酸通过调节Nrf2/HO-1/GPX4信号通路促进红细胞生成并减轻蚕豆病模型大鼠氧化应激及铁死亡
Muhammed Ramadan Galal,Ayman Saber Mohamed,Ahmed Abdel Aziz Bayoumi et al.
Muhammed Ramadan Galal et al.
Anemia is a public health issue affecting people of all ages worldwide. 43% of children under five in Egypt are suffering from anemia. Hemolytic anemia (HA), characterized by the premature destruction of red blood cells, is often associated...
Caveolin 1 has a comparable role as endothelial progenitor cells to repair vascular endothelial dysfunction caused by the combined exposure to arsenic and lipid [0.03%]
Caveolin 1在砷和血脂联合作用引起的血管内皮功能障碍修复中的作用类似于内皮祖细胞的作用
Jinyu Li,Jing He,Jin Cheng et al.
Jinyu Li et al.
To date, no study has focused on the combined effects of arsenic and lipid exposure on vascular disorders. Substantial evidence indicates that vascular endothelial dysfunction is a primary driver of vascular diseases. EPCs exert pivotal rol...
A Potential Anti-Aging Probiotic: Lactobacillus paracasei JS-3 Extends Lifespan in Caenorhabditis elegans and Modulates the Gut Microbiota in the Elderly [0.03%]
潜在抗衰老益生菌：乳酸菌paracasei JS-3延长秀丽隐杆线虫的寿命并调节老年人肠道微生物群
Aji Li,Houxier Li,Li Yang et al.
Aji Li et al.
Probiotics have garnered considerable attention due to their multifunctional properties, which encompass the maintenance of intestinal homeostasis, the modulation of immune responses, and the exertion of antioxidant activities. Thus, this s...