Itaconic acid regulates endoplasmic reticulum stress and apoptosis via SERCA2 to alleviate ovarian dysfunction in laying hens with fatty liver hemorrhage syndrome [0.03%]
衣康酸通过SERCA2调节内质网应激和凋亡以缓解脂肪肝综合征产蛋母鸡的卵巢功能损伤
Jiayi Ding,Chun Zeng,Yang Hu et al.
Jiayi Ding et al.
Fatty liver hemorrhage syndrome (FLHS), a common nutritional metabolic disorder, exerts a significant impact on poultry egg production due to its detrimental effect on reproductive performance, while the underlying mechanism involving the o...
GSTM1 upregulation contributes to ursolic acid-alleviated hepatic steatosis and liver injury in chronic alcohol-fed mice [0.03%]
尿石素缓解慢性酒精喂养小鼠肝脏脂肪变性和肝损伤的作用机制研究
Tiantian Xu,Yue Jin,Aiwen Pi et al.
Tiantian Xu et al.
Alcohol-associated liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, has been reported to exert protective effects against ALD; however, its...
Macrophages alter T helper cell balance and attenuate mast cell degranulation in tropomyosin-induced food allergy [0.03%]
巨噬细胞改变T淋巴细胞平衡并减轻肌动蛋白诱导的食品过敏引起的肥大细胞脱颗粒反应
Jiasen Zhang,Yuwei Feng,Yi Huang et al.
Jiasen Zhang et al.
Food allergy is a complex immune-mediated disorder involving multiple immune cell populations. Macrophages play an important role in both innate and adaptive immune responses. However, their contribution to food allergy remains incompletely...
Attenuation of diet-induced hepatic steatosis by capric acid-rich MLM structured lipids in an obese mouse model [0.03%]
一种肥胖小鼠模型中月桂酸含量丰富的MLM结构脂质对饮食诱导的肝脂肪变性的抑制作用
Angie Vanessa Caicedo-Paz,Camila Andrea Farías-Castro,Cassamo Ussemane Mussagy et al.
Angie Vanessa Caicedo-Paz et al.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a major hepatic manifestation of obesity and insulin resistance and represents a growing global health burden. Dietary lipid structure plays a decisive role in ...
Lycopene, quercetin and silymarin alleviate tartrazine-induced liver injury via modulating Nrf2 signaling and endoplasmic reticulum stress pathways [0.03%]
番茄红素、槲皮素和水飞蓟素通过调节Nrf2信号通路和内质网应激途径缓解 tartrazine 致肝损伤
Sally K Hammad,Sousou I Ali,Mohamed A Shaheen et al.
Sally K Hammad et al.
Tartrazine is a synthetic lemon-yellow azo dye that is widely used as a coloring agent in food products, drugs, and cosmetics. Tartrazine was reported to induce hepatotoxicity, however, the effects of tartrazine on Nrf2 signaling and endopl...
Corrigendum to "D-Allulose improves mitochondrial respiratory function and alleviates obesity-induced liver dysfunction: A comparative study with erythritol in HFD-fed mice" [The Journal of Nutritional Biochemistry 147 (2026) 110135] [0.03%]
D-阿洛糖改善线粒体呼吸功能，缓解肥胖诱导的肝损伤：与木糖醇在高脂饮食喂养小鼠中的比较研究的勘误项
Su-Kyung Shin,Eun Ji Kim,Sung-Su Choi et al.
Su-Kyung Shin et al.
Zinc modulates metallothionein remodeling and lipid metabolism in human epithelial cells under inflammatory stress [0.03%]
锌调节炎症压力下人类上皮细胞金属硫蛋白重塑和脂质代谢
Ana Álvarez-Barrios,Marcos Bouza,Beatriz Fernández-Vega et al.
Ana Álvarez-Barrios et al.
Zinc deficiency and chronic low‑grade inflammation are prevalent conditions that compromise epithelial integrity and metabolic homeostasis, particularly in ageing populations. Here, we investigated the concentration-dependent effects of Zn...
Ketogenic diet improves motor and anxiety-like behaviors plus cerebellar inflammation via axonal remyelination in the BTBR mouse model of autism [0.03%]
生酮饮食通过轴突脱髓鞘再形成改善BTBR自闭症小鼠模型的运动和类似焦虑的行为及小脑炎症
Raffaella Alò,Ilaria Olivito,Damiana Minervini et al.
Raffaella Alò et al.
Background: Different evidence suggests that ketogenic diet (KD) ameliorates neurological disfunctions including core symptoms of autism spectrum disorders (ASD). In view of this, we have hypothesized that KD may induce a...
High fat diet-induced diversity reduction in gut microbiota facilitates the development of systemic lupus erythematosus [0.03%]
高脂饮食诱导的肠道微生物多样性降低促进系统性红斑狼疮的发展
Yu-Jih Su,Brian Yu-Ting Kuo,Leo Yen-Ting Lin et al.
Yu-Jih Su et al.
Systemic lupus erythematosus (SLE) is influenced by environmental, genetic, and dietary factors. The impact of a high-fat diet (HFD) on SLE pathogenesis remains unclear. To investigate this, we utilized an imiquimod (IMQ)-induced SLE mouse ...
Time-restricted feeding alleviates heat stress-induced liver ferroptosis in piglets via nuclear receptor NR1D1-mediated transcription modulation [0.03%]
限时喂食通过核受体NR1D1介导的转录调控缓解热应激诱导的仔猪肝铁死亡
Yanli Zhu,Long Yuan,Cuipeng Zhu et al.
Yanli Zhu et al.
Background: Heat stress (HS) disturbs hepatic metabolic homeostasis and redox balance, compromising antioxidant capacity and mitochondrial function. Ferroptosis, a lipid peroxidation-associated form of regulated cell deat...