Atraric acid alleviates high-fat diet-induced cardiac injury via eEF2K [0.03%]
atraric酸通过eEF2K缓解高脂饮食诱导的心脏损伤
Xiao Liu,Wenting Zhu,Xinran Li et al.
Xiao Liu et al.
A high-fat diet (HFD) is a major contributor to metabolic diseases, causing cardiac injury through inflammation, oxidative stress, and apoptosis mechanisms. Atraric acid (AA) is a natural compound with anti-inflammatory and metabolic regula...
Intestinal-specific ketohexokinase deficiency ameliorates high fructose-induced metabolic dysfunction across the intestinal-liver-kidney axis in mice [0.03%]
肠道特异性酮己六激酶缺乏通过肠-肝-肾轴改善小鼠高果糖诱导的代谢紊乱
Shanshan Song,Xiaoli Yi,Mulan Wang et al.
Shanshan Song et al.
The small intestine, one of the three major sites for ketohexokinase (KHK, also known as fructokinase) expression, plays a crucial role in fructose-related pathological processes, primarily by regulating fructose absorption and its subseque...
Diosgenin inhibits necroptosis to alleviate NAFLD by blocking the RIPK1/RIPK3/MLKL pathway [0.03%]
薯蓣皂苷通过阻断RIPK1/RIPK3/MLKL途径抑制坏死性凋亡从而改善非酒精性脂肪肝病
Muxi Qi,Guoliang Yin,Shujun Wang et al.
Muxi Qi et al.
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. Necroptosis is a controlled, programmed form of cell death, with its core comprising a highly conserved signaling pathway that primarily...
Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling [0.03%]
ferritin介导的铁稳态调节心肌成纤维细胞活化及心脏重塑作用的研究
Mantang Jiang,Ting Liu,Jiayan Shi et al.
Mantang Jiang et al.
Myocardial infarction (MI) triggers dynamic tissue remodeling in which fibroblast activation critically determines scar formation and long-term cardiac function. Although iron dysregulation has been implicated in acute myocardial injury, it...
Vitamin D attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and downregulates hepatic gluconeogenesis in obesity [0.03%]
维生素D可减轻代谢紊乱相关肝脂肪变性疾病(MASLD)并抑制肥胖状态下的肝脏糖异生作用
Maiara M Cordeiro,Naiara Cristina Lucredi,Vanesa Oliveira Pateis et al.
Maiara M Cordeiro et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is often linked to vitamin D deficiency. Insulin resistance (IR) plays a central role in MASLD and is tied to an abnormal activation of hepatic gluconeogenesis, contributing t...
Moderate iron restriction improves metabolism via epigenetic regulation of GDF15 [0.03%]
中度限制铁摄入通过表观遗传学调控GDF15改善代谢
Jinying Yang,Limin Shi,Anna L Cubito et al.
Jinying Yang et al.
Iron overload disrupts endocrine function and metabolic health, while iron chelation and phlebotomy enhance metabolic fitness in humans and mice. However, the working mechanism of iron-lowering strategies remains largely undefined, and it i...
Gut microbiota reshaped by exercise improved glycolipid metabolism in obese mice via increasing the production of medium and long chain fatty acids: a multi-omics study [0.03%]
运动重塑的肠道菌群通过增加中长链脂肪酸产生改善肥胖小鼠糖脂代谢：多组学研究
Xin Zhang,Xin-Ran Wang,Sai-Lun Gai et al.
Xin Zhang et al.
Exercise is effective in combating obesity and regulating the composition of the gut microbiota. However, the molecular mechanism by which exercise alters gut microbiota and its metabolites to exert weight loss has not been fully elucidated...
Mechanistic Insights into Fluoride-Induced Male Reproductive Injury: The Role of Nrf2/FSP1 Pathway-Mediated Ferroptosis [0.03%]
氟化物致雄性生殖损伤的机制研究：Nrf2/FSP1通路介导的铁死亡作用不容忽视
Yan Wang,Chunxiang Li,Xiaoli Fu et al.
Yan Wang et al.
Global environmental fluoride contamination causes damage to multiple organs, with the male reproductive system being particularly susceptible. Nevertheless, the precise pathophysiological mechanisms underlying this vulnerability remain poo...
Lactobacillus casei Zhang modulates hippocampal metabolism and cognition in T2DM rats: A microbiota-gut-brain axis study [0.03%]
植物乳杆菌通过调控肠道菌群发挥改善2型糖尿病大鼠海马糖代谢和认知功能的作用研究
Yue Cai,Xuxia Wang,Huili Liu et al.
Yue Cai et al.
Purpose: The gut plays a pivotal role in metabolic disorders, providing a tractable target for type 2 diabetes mellitus (T2DM) prevention. Although Lactobacillus casei Zhang (LCZ) demonstrates cognitive benefits in T2DM, ...
Deoxycholic Acid Ameliorates Postmenopausal Osteoporosis by Rebalancing BMSC Differentiation and Suppressing NF-κB Signaling [0.03%]
脱氧胆酸通过调节骨髓间充质干细胞分化和抑制NF-κB信号来改善绝经后妇女的骨质疏松症
Cui Wang,Lu Liu,Jialu Wu et al.
Cui Wang et al.
Postmenopausal osteoporosis (PMOP) represents a significant global health issue associated with aging, primarily driven by estrogen deficiency. Although the gut-bone axis has garnered increasing attention, the specific bioactive metabolites...