Targeting xCT-mediated amino acid metabolism: A novel mechanism of silymarin in ameliorating MAFLD-associated ferroptosis [0.03%]
靶向xCT介导的氨基酸代谢：奶蓟草提取物水飞蓟宾通过改善MAFLD相关铁死亡的新机制
Hongli Xu,Ji Sun,Ning Ding et al.
Hongli Xu et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) affected approximately 25% of the global population, resulting in a huge economic burden. Silymarin, a traditional European herbal remedy with known...
Transcriptomic profiling reveals T cell-mediated Glutamine immunomodulation via CD8A / LCK / LAT signaling in the liver model of piglets [0.03%]
转录组分析揭示了猪仔肝模型中T细胞介导的谷氨酰胺免疫调节通过CD8A/LCK/LAT信号通路
Guowei Liu,Yujie Cheng,Yiyu Zhang et al.
Guowei Liu et al.
Glutamine (Gln) is the body's most abundant and versatile amino acid, playing a crucial role in immune responses. The liver, a highly vascularized and metabolically active organ, has a strong regenerative capacity and is vital for immune fu...
Maternal fructose consumption differentially programs the allergic airway response in male and female mouse offspring [0.03%]
母体果糖摄入量会分别改变小鼠后代过敏性呼吸道反应
Amanda Santos Cavalcante,Rodrigo Rodrigues E Lacerda,Carolina Vieira Campos et al.
Amanda Santos Cavalcante et al.
Epidemiological studies describe a positive correlation between sugar consumption during pregnancy and the risk for atopic respiratory diseases in the progeny. In the present study we developed an experimental model to test whether the offs...
(Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people [0.03%]
茋和甲基黄烷醇的代谢产物及其与老年人认知和心血管代谢健康的关联
Yong Li,Melanie Le Sayec,Yifan Xu et al.
Yong Li et al.
Dietary (poly)phenols and methylxanthines may help lower the risk of developing neurodegenerative diseases. However, the relationship between (poly)phenols and methylxanthines and age-related cognitive impairment has not been fully explored...
Manipulation of Hepatic Manganese Levels through the Exporter SLC30A10 does not Alter Plasma Lipid Homeostasis [0.03%]
通过肝出口器SLC30A10操纵肝脏中的锰水平不会改变血浆脂质稳态
Mei-Shi Liu,Tie-Ning Xie,Ting Wang et al.
Mei-Shi Liu et al.
Manganese (Mn) is involved in hepatic lipoprotein secretion, and dietary Mn supplementation has been proposed as a potential therapeutic strategy for hyperlipidemia. SLC30A10 is a unique transporter responsible for Mn efflux from hepatocyte...
Enhanced metabolic benefits of dietary methionine restriction in cold resistant hybrid UCP1-deficient mice [0.03%]
冷适应性UCP1基因敲除小鼠中饮食蛋氨酸限制的代谢益处增强
Rea P Anunciado-Koza,Crystal Bilodeau,Diana Cooke et al.
Rea P Anunciado-Koza et al.
Dietary methionine restriction (MR) improves metabolic health in various animals. Beneficial effects on mice include reduced obesity and improved metabolism associated with the appearance of multilocular uncoupling protein 1 (UCP1) positive...
Early-life dietary long-chain polyunsaturated fatty acid consumption promotes immune function and reduces systemic and adipose inflammation in a sex-specific manner in obese Wistar rats [0.03%]
生命早期饮食中的长链多不饱和脂肪酸摄入以性别特异性的方式促进肥胖Wistar大鼠的免疫功能并减少全身和脂肪组织炎症
Ren Wang,Susan Goruk,Catherine B Chan et al.
Ren Wang et al.
Long-chain polyunsaturated fatty acids (LCPUFA) promote immune development and improve obesity-related inflammation. This study determined the effects of LCPUFA-supplemented diets (age Wk3-10) fed to male and female rats on: 1) anthropometr...
SIRT3 ameliorates hepatic inflammation, oxidative stress, and fibrosis in HFD- or MCD diet-fed mice [0.03%]
SIRT3可改善高脂饮食或胆管结扎小鼠的肝脏炎症、氧化应激和纤维化
Huifang Lv,Wenyue Sun,Cuixia Tian et al.
Huifang Lv et al.
Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis (MASLD/MASH), has emerged as one of the leading causes of cirrhosis and hepatocellular carcinoma. Currently, no specific pharmacol...
Tregs are key mediators of renal dysfunction induced by low-dose fluoride exposure [0.03%]
低剂量氟诱导的肾功能损伤与Treg细胞的关键介导作用密切相关
Bingshu Liu,Shujuan Pang,Siqi Zhu et al.
Bingshu Liu et al.
Against the backdrop of generally reduced fluoride exposure levels in the current environment, the immune barrier function, as the core of the body's defense system, has attracted significant attention for its role in immune regulation unde...
Evaluation of absorption kinetics and bioavailability of Palmitic acid and 2-palmitoylglycerol radiolabeled with 99m-Technetium [0.03%]
99m- technetium标记棕榈酸和1,3-二棕榈酰-2-甘油的体内吸收动力学及生物利用度研究
Penélope Lacrísio Dos Reis Menta,Maria Emília Rabelo Andrade,Amanda Dias Borges et al.
Penélope Lacrísio Dos Reis Menta et al.
Interesterified fat (IF) has replaced partially hydrogenated fats because it does not generate trans isomers, but it may affect lipid metabolism due to structural changes in triacylglycerols (TAGs). Since chemical interesterification alters...