Iron overload activates NF-κB-driven hepatic inflammation in suckling rats [0.03%]
铁过载激活NF-κB驱动的哺乳期大鼠肝炎炎症反应
Lili Qiu,Xiyu Qin,Mengxiao Hu et al.
Lili Qiu et al.
Iron is crucial for infant development but excessive iron intake may adversely affect liver. The neonatal period is critical for liver development and immune system maturation, during which the liver is particularly vulnerable to iron overl...
NCOA4-dependent ferritinophagy: a key mechanism of Selenium deficiency-induced ferroptosis and porcine phlebitis via the AMPK-mTOR pathway [0.03%]
NCOA4依赖性铁蛋白自噬：通过AMPK-mTOR途径介导的硒缺乏诱导的铁死亡和猪静脉炎的关键机制
Yaning Qiu,Ruirui Xie,Guodong Bi et al.
Yaning Qiu et al.
Selenium (Se) is an essential trace element for maintaining cardiovascular health. Although Se deficiency is associated with various vascular diseases, its precise role in venous endothelial injury remains unclear. Therefore, we established...
Yaxin Luo,Junjun Li,Yuxin Yang et al.
Yaxin Luo et al.
Breast cancer (BC) is one of the most prevalent malignant tumors among women globally. This disease is modulated by the interaction of multiple complex factors and exhibits a high mortality rate, posing a severe threat to women's lives and ...
Amelioration of Hepatic Steatosis in Male Obese Rats by High-Protein Diet is Dependent upon Protein Source [0.03%]
高蛋白饮食改善雄性肥胖大鼠肝脂肪变性的效果依赖于蛋白质来源
Fadi H J Ramadan,Peter Zahradka,Carla G Taylor
Fadi H J Ramadan
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by triglyceride accumulation and insulin resistance. Currently, weight loss remains the primary strategy for reducing ...
The protective role of Astaxanthin against the central and peripheral detrimental effects for chronic administration of sweeteners in a rat model: Involvement of multiple signaling axes [0.03%]
虾青素通过多种信号轴在甜味剂慢性给药导致的中枢和外周损害中的保护作用：多种信号轴的参与
Ahmed M E Hamdan,Karema Abu-Elfotuh,Reem Alshaman et al.
Ahmed M E Hamdan et al.
Background: Obesity and diabetes are escalating worldwide health concerns, prompting the use of non-caloric sweeteners such as aspartame and stevia as substitutes for sucrose; however, their long-term physiological and be...
Nutritional and Metabolic Signatures in Pediatric Phenylketonuria and Hyperphenylalaninemia: Insights from Untargeted Urinary Metabolomics [0.03%]
儿童苯酮尿症和高苯丙氨酸血症的营养及代谢特征：非靶向尿液代谢组学研究的新见解
Blanca Barrau-Martinez,Arnau Gonzalez-Rodriguez,Dolores Garcia-Arenas et al.
Blanca Barrau-Martinez et al.
Dietary interventions are essential for managing phenylketonuria (PKU) and may influence metabolic regulation beyond phenylalanine control. We characterized the urinary metabolomic fingerprint of pediatric participants (n = 82) recruited in...
Isoquercitrin Attenuates Osteoarthritis Progression by Targeting P53-Mediated Ferroptosis: A Mechanistic Study Integrating Network Pharmacology and Experimental Validation [0.03%]
异檞皮素通过靶向P53介导的铁死亡抑制骨关节炎进展：网络药理学和实验验证相结合的机制研究
Huajie Li,Guanghui Chen,Chi Ma et al.
Huajie Li et al.
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive destruction of articular cartilage. Isoquercitrin (ISO), a natural flavonoid, has well-documented anti-inflammatory and antioxidant properties. This study inve...
Leonurine alleviates HFD-induced inflammation and dyslipidemia via modulating gut microbiota-derived indole-3-propionic acid signaling [0.03%]
淫羊藿碱通过调节肠道菌群衍生的印防己酸信号来缓解高脂饮食引起的炎症和血脂异常
Tianlan Xi,Wenli Jiang,Zilang Luo et al.
Tianlan Xi et al.
High-fat diet (HFD) induces metabolic disturbances, in which gut microbiota and metabolites play a critical role. Although leonurine (LE) has demonstrated lipid-lowering effects, whether it ameliorates metabolic disorders through gut microb...
Bioactive Metabolites in Neonates of Mothers Supplemented with Bifidobacterium animalis are Linked to Microbiota-related Compounds in Milk and Maternal Plasma in Mice [0.03%]
母体补充动物双歧杆菌对新生鼠活性代谢产物的影响与乳汁和母体血浆中菌群相关化合物的联系
Patrícia Brito Rodrigues,Clara Valentin,Essozinam Woenande et al.
Patrícia Brito Rodrigues et al.
Maternal supplementation with Bifidobacterium animalis subsp. lactis (B. lac) in mice improves influenza virus infection resolution. Transmission pathways from mother to neonate are not fully identified. Benefits may be linked to metabolic ...
Inositol Hexaphosphate and Inositol Prevent WD/CCl₄-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice [0.03%]
肌醇和肌醇六磷酸通过预防WD / CCl4诱导的代谢紊乱相关肝炎来防止小鼠发生WD / CCl4诱导的代谢紊乱相关脂肪性肝炎
Zhao Chen,Yiman Luan,Danli Yang et al.
Zhao Chen et al.
Given the significant clinical and economic burden of metabolic dysfunction-associated steatohepatitis (MASH), there is an urgent imperative to develop effective preventive and therapeutic agents. In this study, we evaluated the preventive ...