Subacute ruminal acidosis induces inflammation, autophagy, and apoptosis by disrupting Ca²⁺ homeostasis via STIM1/ORAI1 upregulation in mammary gland tissues [0.03%]
STIM1/ORAI1上调诱导Ca²⁺稳态紊乱通过炎症、自噬和凋亡参与亚急性瘤胃酸中毒小鼠乳腺组织损伤
Meijuan Meng,Xuran Ren,Xuerui Li et al.
Meijuan Meng et al.
Subacute ruminal acidosis (SARA) is a prevalent metabolic disorder in ruminants that induces mastitis, while Ca²⁺ homeostasis disruption is closely linked to mammary gland diseases. This study aimed to uncover the role of Ca²⁺ signaling...
Time-restricted feeding improves cognitive function in Alzheimer's mice through GCK/NPY/apoptosis pathway [0.03%]
限时喂养通过GCK/NPY/凋亡途径改善阿尔茨海默病小鼠的认知功能
Zhijun Zhang,Jingyun Yang,Zhili Niu et al.
Zhijun Zhang et al.
Background: Alzheimer's disease (AD) is characterized by progressive cognitive decline, neuronal loss, and circadian disruption. Time-restricted feeding (TRF), a dietary intervention that aligns feeding with circadian rhy...
Hesperetin Alleviates High-Fat Diet-Induced NAFLD by Activating FXR to Modulate Ferroptosis Homeostasis and Suppress Inflammation [0.03%]
hesperetin通过激活FXR调节铁死亡稳态和抑制炎症来缓解高脂饮食引起的NAFLD
Suwen Chen,Jin Xie,Guoliang Yin et al.
Suwen Chen et al.
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide, yet effective treatment options remain limited. Hesperetin (HES), a natural flavonoid, shows potential for ameliorating NAFLD, but its underlying m...
Dietary sulforaphane glucosinolate alleviates stress-induced depression and demyelination through gut-brain axis modulation [0.03%]
通过调节肠道-大脑轴，饮食中硫代葡萄糖甘氨酸减轻压力引起的抑郁和脱髓鞘症状
Dan Xu,Akifumi Eguchi,Rumi Murayama et al.
Dan Xu et al.
Chronic stress is a major risk factor for depression and white matter injury, yet effective preventive strategies remain limited. Here, we investigated whether an 8-week diet supplemented with 0.1% sulforaphane glucosinolate (SGS) could pre...
Selenium Accumulated Exposure Aggravates the Progression of Type 2 Diabetes Mellitus via Activating the IRF2/Caspase-4/GSDMD Pyroptosis Pathway [0.03%]
硒累积暴露通过激活IRF2/Caspase-4/GSDMD焦亡通路加剧2型糖尿病 mellitus进展
Lancheng Wei,Zhen Lee,Junhao Shan et al.
Lancheng Wei et al.
Emerging evidence suggests a potential association between high selenium (Se) exposure and the development of type 2 diabetes mellitus (T2DM), a condition often associated with chronic low-grade inflammation. Pyroptosis, a form of programme...
Salvia plebeia R. Br. extract delays cellular senescence and promotes healthy aging via Atg7-dependent autophagy, with rosmarinic acid as a major bioactive constituent [0.03%]
丹酚酸通过Atg7依赖的自噬延迟细胞衰老并促进健康老龄化研究
Yan-Ni He,Shi-Ying Li,Pei Xu et al.
Yan-Ni He et al.
Aging is characterized by progressive cellular dysfunction and increased susceptibility to chronic diseases. Enhancing autophagy, a key cellular clearance process, offers a promising strategy to combat aging. In this study, we investigated ...
Guaiacol counters renal fibrosis via BMP/ERK/Smad1/5/9 signalling in UUO-induced chronic kidney disease [0.03%]
愈创木酚通过BMP/ERK/Smad1/5/9信号通路对抗肾纤维化以治疗输尿管梗阻诱导的慢性肾脏疾病
Hrushikesh Vikas Kulkarni,Anil Bhanudas Gaikwad
Hrushikesh Vikas Kulkarni
Chronic kidney disease (CKD) is characterized by progressive fibrosis and inflammation, with limited therapeutic options. Natural compounds have been studied for their potential to offer kidney-protective benefits, especially in CKD. Guaiac...
Integrated metagenomic and metabolomic profiling in an in vitro colonic fermentation study to assess the impacts of conventional, unconventional, and whole edible beet (Beta vulgaris L.) parts on the composition and metabolic responses of the intestinal microbiota of hypertensive individuals [0.03%]
一项体外结肠发酵研究综合了宏基因组和代谢组分析，评估常规、非传统以及整株甜菜（Beta vulgaris L.）部位对高血压个体肠道菌群组成及代谢反应的影响
Andressa Cavalcante do Nascimento,Thatyane Mariano Rodrigues de Albuquerque,Déborah Gomes de Oliveira et al.
Andressa Cavalcante do Nascimento et al.
Beet (Beta vulgaris L.) has been widely studied as a functional food, particularly for its bioactive compounds. This study evaluated the physicochemical characteristics, nutritional composition, antioxidant capacity, and the impacts of free...
Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice [0.03%]
褐藻素通过改善皮肤衰老和调节全身衰老标志物延缓自然老化小鼠机体衰老的作用机制研究
Jiyao Fei,Yu Yanai,Shuyu Liu et al.
Jiyao Fei et al.
Fucoxanthin, a well-known xanthophyll obtained from marine algae, has been documented to exhibit multiple physiological and health-promoting effects. In this study, we investigated the impact of dietary administration with fucoxanthin (0.01...
Transcriptomics and metabolomics reveal the alleviating effect of lycopene on di-(2-ethylhexyl) phthalate-induced hepatotoxicity in mice [0.03%]
转录组学和代谢组学联合揭示番茄红素改善DEHP所致小鼠肝损伤的作用机制
Yi Liu,Jia-Li Liu,Li-Jian Chen et al.
Yi Liu et al.
Di(2-ethylhexyl) phthalate (DEHP), a prevalent plasticizer in medical, personal care, and food packaging items, leads to extensive human exposure and liver accumulation, resulting in notable liver toxicity. Lycopene (Lyc), a strong antioxid...