Cooked common bean flour, but not its protein hydrolysate, has the potential to improve gut microbiota composition and function in BALB/c mice fed a high-fat diet added with 6-propyl-2-thiouracil [0.03%]
熟黑豆粉，而不是其蛋白水解物，具有改善6-丙基-2-硫脲添加的高脂饮食BALB/c小鼠肠道微生物组组成和功能的潜力
Mariana Juste Contin Gomes,Juliana Soares da Silva,Natalia Elizabeth Galdino Alves et al.
Mariana Juste Contin Gomes et al.
Common bean has the potential to improve gut microbiota function due to its chemical composition and content of dietary fiber. This study evaluated the effect of cooked common bean (CCB) flour and its protein hydrolysate as part of a high-f...
Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice [0.03%]
茯苓寡糖通过调控肠道菌群和肠内代谢物改善高脂饮食小鼠糖脂代谢紊乱
Lin Zhu,Cheng Ye,Baifei Hu et al.
Lin Zhu et al.
In this study, we aimed to explore the effect of Poria cocos oligosaccharides (PCO) on glucolipid metabolism disorder. Based on a high-fat diet (HFD)-induced obese mouse model, we demonstrated that PCO ameliorated glucose intolerance and in...
Successful correction of hyperglycemia is critical for weight loss and a decrease in cardiovascular risk in obese patients [0.03%]
成功纠正高血糖对肥胖患者减肥和降低心血管风险至关重要
Jolanta Zalejska-Fiolka,Anna Birková,Beáta Hubková et al.
Jolanta Zalejska-Fiolka et al.
Weight loss is recommended for obese patients with cardiovascular risk; however, it remains questionable how hyperglycemia affects this process. To address this problem, we aimed to determine the association between weight loss, lipid profi...
Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism [0.03%]
氯ogenic酸通过多种途径改善蛋氨酸和胆碱缺乏性饮食诱导的小鼠非酒精性脂肪肝病及其机理研究
Hui Miao,Hao Ouyang,Qian Guo et al.
Hui Miao et al.
Nonalcoholic steatohepatitis, one of the most common chronic liver diseases, is a progressive form of nonalcoholic fatty liver disease accompanied by the development of liver fibrosis. Chlorogenic acid (CGA) is a natural polyphenolic compou...
Patterns of alpha-linolenic acid incorporation into phospholipids in H4IIE cells [0.03%]
α-亚麻酸在H4IIE细胞磷脂中的引入模式
Danielle Defries,Kayla Curtis,Jay C Petkau et al.
Danielle Defries et al.
Alpha linolenic acid (ALA) is an 18-carbon essential fatty acid found in plant-based foods and oils. While much attention has been placed on conversion of ALA to long chain polyunsaturated fatty acids, alternative routes of ALA metabolism e...
Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes [0.03%]
萝卜硫素通过激活AMPK-mTOR-ULK1信号通路诱导脂质自噬作用研究
Masashi Masuda,Risa Yoshida-Shimizu,Yuki Mori et al.
Masashi Masuda et al.
Lipophagy, a form of selective autophagy, degrades lipid droplet (LD) in adipose tissue and the liver. The chemotherapeutic isothiocyanate sulforaphane (SFN) contributes to lipolysis through the activation of hormone-sensitive lipase and th...
Suboptimal folic acid exposure rewires oncogenic metabolism and proteomics signatures to mediate human breast cancer malignancy [0.03%]
亚最优叶酸暴露重新连接致癌代谢和蛋白质组学标志物以介导人类乳腺癌恶性肿瘤的发展
Angel Huang,Su-Yu Huang,Pramod Shah et al.
Angel Huang et al.
Whether treatment with folic acid (FA) affects human breast cancer positively or negatively remains unclear. We subjected human Michigan Cancer Foundation-7 cells, a human breast cancer cell line, to suboptimal FA at low levels (10 nM; LF) ...
Differential effects of saturated and unsaturated free fatty acids on ferroptosis in rat β-cells [0.03%]
饱和和不饱和脂肪酸对大鼠胰岛β细胞铁死亡的差异影响
Bastian Krümmel,Anna-Sophie von Hanstein,Thomas Plötz et al.
Bastian Krümmel et al.
Elevated plasma concentrations of saturated free fatty acids (SFAs) are involved in pancreatic β-cell dysfunction and apoptosis, referred to as lipotoxicity. However, in contrast to apoptosis, the involvement of ferroptosis, as a distinct ...
High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice [0.03%]
高胆固醇和27-羟基胆固醇通过损害自噬促进tau蛋白磷酸化导致C57BL/6J小鼠学习记忆障碍
Tao Wang,Xiaona Zhang,Yushan Wang et al.
Tao Wang et al.
Cholesterol and its oxidative derivative 27-hydroxycholesterol (27-OHC), synthesized by CYP27A1, play an important role in Alzheimer's disease (AD) and phosphorylation of tau might be partly responsible for its pathogenesis. To investigate ...
Epigenetic disruption of placental genes by chronic maternal cafeteria diet in rats [0.03%]
慢性母体西方饮食可导致大鼠胎盘基因表观遗传改变
Maria Paula Gastiazoro,Maria Florencia Rossetti,Rocío Schumacher et al.
Maria Paula Gastiazoro et al.
Maternal diet has impact on reproduction, fetal development and offspring behavior, although molecular mechanisms remained unknown. Our aims were to assess (1) the effects of a cafeteria (CAF) diet (western diet habits) on female reproducti...