The characteristic of microglia and gut-microglia-brain axis: implications for cognitive impairment and therapeutic strategies [0.03%]
小胶质细胞及其肠-小胶质细胞-脑轴的特征：认知障碍及治疗策略的启示
Jun Zhou,Liujie Zheng,Ziyi Zheng et al.
Jun Zhou et al.
Aging-associated cognitive impairment (CI) is a core feature of neurodegenerative diseases, profoundly affecting the daily life of patients. Microglial dysfunction significantly contributes to the pathogenesis of CI. The gut-brain axis serv...
Quercetin mitigates CUMS-induced depression-like behaviors in rats by regulating Argininosuccinic Acid-induced astrocyte pyroptosis in the hippocampus [0.03%]
槲皮素通过调节精氨酸琥珀酸致海马星形胶质细胞炎性焦亡减轻慢性不可预测轻度应激诱导的大鼠抑郁样行为
Siqi Li,Qiong Wu,Ying Chen et al.
Siqi Li et al.
Depression, or major depressive disorder (MDD), is a prevalent psychological disorder, but its underlying mechanisms remain understood, hindering effective prevention and treatment. This study investigated the protective effects of querceti...
Effect of probiotic yogurt on short-chain fatty acids, inflammation, and oxidative stress biomarkers: A systematic review and meta-analysis of randomized controlled trials [0.03%]
益生菌酸奶对短链脂肪酸、炎症和氧化应激生物标志物的影响：随机对照试验的系统评价和meta分析
Mariano Gallo Ruelas,Gian Pierre Gomez-Herrera,Andrea Albornoz-Pinedo et al.
Mariano Gallo Ruelas et al.
Short-chain fatty acids (SCFAs) production by fermented foods is a promising health strategy regarding inflammation and oxidative stress regulation. However, there is uncertainty whether probiotic yogurt is truly superior to conventional yo...
Prenatal nutrition modulates hepatic long non-coding RNA regulatory elements in Nellore cattle offspring [0.03%]
母体营养可调节Nellore牛后代肝细胞长链非编码RNA的调控元件
Guilherme Henrique Gebim Polizel,Angela Cánovas,Aline Silva Mello Cesar et al.
Guilherme Henrique Gebim Polizel et al.
This study investigated the effects of maternal nutrition on hepatic long non-coding RNA (lncRNA) expression in Nellore cattle offspring. To this end, a total of 126 pregnant cows were assigned to three dietary treatments: NP (mineral suppl...
Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome [0.03%]
整合代谢组学和元基因组学分析鉴定出了一种独特的特征用于表征代谢综合征
Sivaporn Wannaiampikul,Brian Lee,Jiarui Chen et al.
Sivaporn Wannaiampikul et al.
Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health,...
Prebiotics partially protect offspring from maternal antibiotic-induced obesity risk by altering maternal milk microbiota and gut colonization in Sprague-Dawley rats [0.03%]
母体抗生素诱导肥胖风险通过改变乳汁菌群及子代肠道定植部分保护后代健康（Sprague-Dawley大鼠模型）
Dana E Lowry,Nicole A Cho,Kara Sampsell et al.
Dana E Lowry et al.
Maternal antibiotic use can increase obesity risk in offspring. Co-administering prebiotics mitigates the risk in rats. How prebiotics and antibiotics interact to affect obesity risk is unknown but could involve altered milk microbiota that...
Dietary daidzein supplementation alleviates myocardial inflammatory injury by modulating estrogen receptor beta-mediated ER stress pathway [0.03%]
大豆异黄酮通过调节雌激素受体β介导的内质网应激通路缓解心肌炎症损伤
Zhongchao Gai,Sijia Yan,Chengyuan Min et al.
Zhongchao Gai et al.
Myocarditis is a clinical condition characterized by inflammation of the myocardium. It commonly occurs in various heart disorders and, in extreme circumstances, can be fatal. However, the effective and safe dietary strategies for alleviati...
Dietary Organosulfur Compounds and the H₂S-Polysulfide Redox Axis: Current Evidence and Limitations [0.03%]
饮食有机硫化物与H₂S-多硫化物氧化还原轴：现有证据和局限性
Nikky Sharma,Tejasvi Pandey,Vivek Pandey
Nikky Sharma
Dietary organosulfur compounds (OSCs) are a structurally diverse class of sulfur-containing food-derived molecules increasingly recognized for their potential interactions with endogenous sulfur and redox metabolism. Emerging evidence, larg...
Integrative perspective on the maternal Gut-Brain-Breast axis: Linking dietary polyphenols, mental health, and human milk composition [0.03%]
整合视角下的母体肠道-大脑-乳腺轴：膳食多酚、心理健康与人乳组成之间的联系
Agustín Ramiro Miranda,Paula Eugenia Barral,Silvana Valeria Serra et al.
Agustín Ramiro Miranda et al.
This narrative review examines the interplay between maternal diet (particularly polyphenol intake), cognition, and human milk composition during the postpartum period. Early motherhood involves substantial neurobiological and psychological...
Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway [0.03%]
Curdione通过依赖Fblim1抑制TGF-β1/Smad3信号通路来缓解肾纤维化
Qianqian Li,Yufang Ni,Zhaoyang Li et al.
Qianqian Li et al.
Chronic Kidney Disease (CKD) inevitably progresses to End-Stage Renal Disease (ESRD) via tubulointerstitial fibrosis, a process predominantly driven by the transforming growth factor-β (TGF-β)/SMAD family member 3 (Smad3) signaling pathwa...