Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation [0.03%]
13顺式视黄酸和托芬那酸联合诱导细胞凋亡并有效抑制高危神经母细胞瘤细胞增殖
Sagar Shelake,Don Eslin,Robert M Sutphin et al.
Sagar Shelake et al.
Chemotherapeutic regimens used for the treatment of Neuroblastoma (NB) cause long-term side effects in pediatric patients. NB arises in immature sympathetic nerve cells and primarily affects infants and children. A high rate of relapse in h...
Variant Rett syndrome in a girl with a pericentric X-chromosome inversion leading to epigenetic changes and overexpression of the MECP2 gene [0.03%]
伴X染色体着丝粒内倒位的雷特综合征女患者由于表观遗传学改变导致MECP2基因过度表达
José Pedro Vieira,Fátima Lopes,Anabela Silva-Fernandes et al.
José Pedro Vieira et al.
Rett syndrome is a neurodevelopmental disorder caused by mutations in the MECP2 gene. We investigated the genetic basis of disease in a female patient with a Rett-like clinical. Karyotype analysis revealed a pericentric inversion in the X c...
Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams [0.03%]
短期艾塞那肽治疗可降低肥胖大鼠后代代谢紊乱的标志物水平
Yik Lung Chan,Sonia Saad,David Simar et al.
Yik Lung Chan et al.
Objectives: Maternal obesity imposes significant health risks in the offspring including diabetes and dyslipidemia. We previously showed that the hypoglycaemic agent exendin-4 (Ex-4) administered from weaning can reverse ...
Developmental changes in the hypothalamic mRNA levels of prepro-orexin and orexin receptors and their sensitivity to fasting in male and female rats [0.03%]
关于下丘脑前肥胖素和肥胖素受体mRNA水平的发育变化及其对饥饿敏感性的性别差异研究
Takeshi Iwasa,Toshiya Matsuzaki,Munkhsaikhan Munkhzaya et al.
Takeshi Iwasa et al.
Orexin, which is also called as hypocretin (Hcrt), a product of the prepro-orexin (pp-orexin//Hcrt) gene, affects various physiological and behavioral functions, such as the sleep-wake cycle and appetite. The developmental changes in the hy...
Neonatal serotonin reuptake inhibition reduces hypercaloric diet effects on fat mass and hypothalamic gene expression in adult rats [0.03%]
新生期血清素再摄取抑制可减轻高热量饮食对成年大鼠脂肪量和下丘脑基因表达的影响
Lígia Cristina Monteiro Galindo,Manuella da Luz Duarte Barros,Isabeli Lins Pinheiro et al.
Lígia Cristina Monteiro Galindo et al.
Background: Serotonin (5-HT) is involved in nervous system ontogenesis, and is important for neurotransmission and behavior modulation after the developmental stage. Alterations in 5-HT levels during the early period of l...
Brain volume and white matter in youth with type 2 diabetes compared to obese and normal weight, non-diabetic peers: A pilot study [0.03%]
与肥胖及体重正常的同龄人相比，2型糖尿病青少年的脑容量和白质差异：一项初步研究
Dana L Rofey,Silva A Arslanian,Nermeen E El Nokali et al.
Dana L Rofey et al.
Type 2 Diabetes Mellitus (T2DM) and obesity are linked to specific patterns of subcortical brain atrophy and decreased microstructural integrity of white matter. Fifteen adolescents (12-21-years-old, 80% Caucasian, 15% African American, mea...
Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy-mediated cell death [0.03%]
围产期脑缺氧-缺血后神经元死亡：自噬介导的细胞死亡的研究重点
C Descloux,V Ginet,P G H Clarke et al.
C Descloux et al.
Neonatal hypoxic-ischemic encephalopathy is a critical cerebral event occurring around birth with high mortality and neurological morbidity associated with long-term invalidating sequelae. In view of the great clinical importance of this co...
The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats [0.03%]
免疫压力对垂体促黄体生成素分泌的抑制作用不在早期新生大鼠中存在
Munkhsaikhan Munkhzaya,Toshiya Matsuzaki,Takeshi Iwasa et al.
Munkhsaikhan Munkhzaya et al.
Some physiological functions display weak responses to stress in the early neonatal period; i.e., they exhibit stress hyporesponse periods. In this study, we evaluated whether gonadotropin regulatory factors exhibit stress hyporesponsive pe...
Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders [0.03%]
中国自闭症谱系障碍儿童的异常蛋氨酸代谢及抗氧化能力下降现象
Yu Han,Qian-qian Xi,Wei Dai et al.
Yu Han et al.
Autism spectrum disorder (ASD) is a neurological disorder that presents a spectrum of qualitative impairments in social interaction, communication, as well as restricted and stereotyped behavioral patterns, interests, and activities. Severa...