Ferroptotic vulnerability drives cardiac fibrosis and diastolic dysfunction in diabetic HFpEF via a gut-associated Proline-PPARγ axis [0.03%]
糖尿病HFpEF中通过与肠道相关的脯氨酸-PPARγ轴驱动心肌纤维化和舒张功能障碍的铁死亡敏感性增高现象
Kai Huang,Jie Lu,Yizhi Yu et al.
Kai Huang et al.
Background: Diabetic heart failure with preserved ejection fraction (HFpEF) is a metabolically driven syndrome characterized by diastolic dysfunction and progressive myocardial fibrosis, yet the cellular mechanisms linkin...
ASAP3 deficiency alleviates hepatic senescence and correlates with extended healthspan in mice [0.03%]
ASAP3缺失可减轻小鼠肝衰老并使其寿命延长
Zhen Tian,Yuhua Song,Xinyue Ao et al.
Zhen Tian et al.
The aging liver not only declines in function but also accelerates systemic aging and shortens lifespan. Identifying key molecular targets to delay liver aging is important for promoting health and longevity. ASAP3 is involved in cytoskelet...
Resveratrol alleviates epilepsy-induced brain damage via the P62-Keap1-Nrf2 Pathway: A multi-omics study integrating the pilot cohort, In silico analyses, and experimental validation [0.03%]
白藜芦醇通过P62-Kelch样环氧氯苯结构域相互作用蛋白(KEAP1)-核因子E2相关因子2(NRF2)信号通路缓解癫痫所致脑损伤：整合首发队列、计算机模拟分析和实验验证的多组学研究
Yuanying Jiang,Ruijin Xie,Yingsi Cao et al.
Yuanying Jiang et al.
Background: Pediatric epilepsy is frequently associated with long-term cognitive, behavioral, and neurodevelopmental impairments. Although oxidative stress and metabolic dysfunction contribute to seizure-induced brain inj...
Cyclophilin D (CypD) promotes mitochondrial impairment, synaptic defects, cognitive loss, and tau pathology during aging [0.03%]
环磷肽素D（CypD）在衰老过程中促进线粒体功能障碍、突触缺陷、认知力下降和tau病理损伤
Margrethe A Olesen,Eduardo Isla,Gail V W Johnson et al.
Margrethe A Olesen et al.
Mitochondrial dysfunction is considered a hallmark of the aging brain, and this organelle can be affected by several neurodegenerative conditions, leading to slowed bioenergetics and reduced energy production. These processes will affect ne...
Glucocorticoids-Driven Mitochondrial GR Translocation Promotes Heat Stress-Induced Mastitis via the mtDNA-cGAS-STING-NF-κB/NLRP3 Pathway [0.03%]
糖皮质激素驱动的线粒体GR易位通过mtDNA-cGAS-STING-NF-κB / NLRP3途径促进热应激诱导的乳腺炎
Yuhong He,Zeming Zhou,Xin Wei et al.
Yuhong He et al.
Heat stress (HS) significantly affects dairy production and animal welfare. However, the precise mechanisms by which HS leads to mastitis remain unclear. To elucidate this, we established a mouse model of HS. Our results show that HS induce...
Polystyrene nanoplastics exacerbated the toxicity of cadmium: from the perspective of the placenta-uterus micro-environment [0.03%]
聚苯乙烯纳米塑料通过胎盘-子宫微环境视角加剧镉毒性作用
Ruiying Zhang,Penghui Nie,Fen Fu
Ruiying Zhang
Heavy metal and plastic pollution are one of most serious environmental problems, which threaten ecological environment and human health. Herein, plastics could be aged fragmented to nanoplastics (NPs) and Cadmium (Cd) as one of the most pr...
DEK recruits KAT6A regulate H3K27ac/c-myc Axis to drive enhanced glycolysis and immune escape in gastric cancer [0.03%]
DEK通过招募KAT6A调节H3K27ac/c-myc轴，驱动胃癌代谢重塑和免疫逃逸
Wenbo Liu,Zhiran Yang,Bingyu Wang et al.
Wenbo Liu et al.
Increased glycolytic activity and immune evasion mechanisms in gastric cancer represent significant impediments to therapeutic advancements. In this study, KAT6A was strikingly upregulated in both gastric cancer tissues and cell lines and w...
LDHA-mediated H3K14 lactylation promotes LRP5 transcription to damage airway epithelial barrier in chronic obstructive pulmonary disease [0.03%]
LDHA介导的组蛋白H3K14乳酸化促进LRP5转录从而损伤慢性阻塞性肺病气道上皮屏障功能
Ming-Yu Wang,Ting-Ting Chen,Jia-Ying Kang et al.
Ming-Yu Wang et al.
Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by chronic airway inflammation and hypoxia, which is closely related to lactylation. However, the molecular mechanism of COPD involving this process remains...
Inhibiting VDAC1 oligomerization attenuated cerebral ischemia-reperfusion injury by promoting mitophagy via reduced LONP1 interaction [0.03%]
抑制VDAC1寡聚化通过减少与LONP1的相互作用促进线粒体自噬以减轻脑缺血再灌注损伤
Xiangna Guo,Huiyi Jiang,Yitian Lu et al.
Xiangna Guo et al.
Increasing evidence highlights the protective role of mitophagy in eliminating damaged mitochondria during ischemic stroke. As a mitochondrial gatekeeper, voltage-dependent anion channel 1 (VDAC1) mediates the elimination of damaged mitocho...