NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of IκBζ [0.03%]
NOX1通过产生活性氧依赖的方式稳定IκBζ从而驱动炎症性肠病
Zhuoyao Song,Coralie Pintard,Anne-Laure Pelletier et al.
Zhuoyao Song et al.
NADPH oxidase 1 (NOX1), predominantly expressed in colonic epithelial cells, regulates mucosal immunity and homeostasis through the production of reactive oxygen species (ROS). However, its dysregulation may contribute to inflammatory bowel...
Epiandrosterone attenuates neuronal ferroptosis after subarachnoid hemorrhage by OGT-mediated FTH O-GlcNAcylation to suppress NCOA4-dependent ferritinophagy [0.03%]
异雄烯二酮通过OGT介导的FTH-O-GlcNAc转移糖基化抑制NCOA4依赖性铁死亡受体介导的铁自噬来缓解蛛网膜下腔出血后的神经元铁死亡
Shengji Ma,Hongrui Yang,Haochen Yan et al.
Shengji Ma et al.
Ferritin heavy chain (FTH) serves as the central iron-storage protein in neurons, yet the regulatory mechanisms governing its stability after subarachnoid hemorrhage (SAH) remain poorly understood. We observed a striking paradox: although F...
Heme oxygenase-1/CO signaling suppresses NLRP3 inflammasome-mediated stromal fibrosis in primary myelofibrosis [0.03%]
血红素加氧酶1/一氧化碳信号通过抑制NLRP3炎性小体介导的间质纤维化治疗原发性骨髓纤维化
Lucia Longhitano,Enrico La Spina,Sebastiano Giallongo et al.
Lucia Longhitano et al.
Inflammation and oxidative stress are critical drivers of bone marrow (BM) fibrosis in primary myelofibrosis (MF). Here, we investigated the interplay between the heme oxygenase-1 (HO-1)/carbon monoxide (CO) pathway and NLRP3 inflammasome a...
Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy [0.03%]
小胶质细胞ATM的丧失导致癫痫中的突触修剪和认知障碍
Yang Hu,Jinyu Zhao,Youli Wang et al.
Yang Hu et al.
Microglia are the resident immune cells of the central nervous system, highly sensitive to oxidative stress and essential for maintaining synaptic homeostasis. While epilepsy induces profound redox imbalance, how oxidative stress reshapes m...
Dual-regulation of mitophagy and cytosolic mtDNA-induced inflammation for the treatment of inflammatory bone loss [0.03%]
调控自噬和细胞质线粒体DNA诱导的炎症治疗炎性骨丢失
Kaiwen Zheng,Benchi Che,Yongzhi Cui et al.
Kaiwen Zheng et al.
Inflammatory osteoporosis, also known as "immunoporosis," is a condition characterized by chronic inflammation and mitochondrial dysfunction, leading to impaired bone regeneration. Mitochondrial DNA (mtDNA) leakage activates the cGAS-STING ...
Lactiplantibacillus plantarum LP15-1 Regulates Intestinal Innate Immunity via Suppressing the NF-κB pathway to Modulate M cell Differentiation [0.03%]
植物乳杆菌LP15-1通过抑制NF-κB通路调节肠道固有免疫从而调控M细胞分化
Shijie Fan,Yue Zheng,Tao Duan et al.
Shijie Fan et al.
Lactobacillus species are increasingly recognized for their essential role in mitigating intestinal inflammation, yet their precise mechanisms of action are not fully understood. This study aimed to investigate the protective effects and un...
Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation [0.03%]
氧化还原敏感的mTOR-eIF4A信号促进选择性P-糖蛋白翻译
Peng Jin,Ming Jin,Luqiu Feng et al.
Peng Jin et al.
Cells face a temporal gap in oxidative stress adaptation, in which acute insults require rapid protein synthesis before transcriptional responses are fully established. Here, we show that low-dose glucosamine (GlcN) induces a transient intr...
NSD2 is a critical regulator of Erastin-induced ferroptosis in keratinocytes [0.03%]
NSD2是角质形成细胞中诱发铁死亡的厄拉-stat的关键调节因子
Ningyuan Liu,Xinrun Zhang,Wei Zhang et al.
Ningyuan Liu et al.
Ferroptosis, an iron-dependent form of regulated cell death, is crucial for skin homeostasis and pathology. The H3K36-specific dimethyltransferase NSD2 is a key epigenetic regulator involved in a spectrum of physiological processes and cont...
Heme-mediated liver-heart axis promotes myocardial pyroptosis in db/db mice [0.03%]
血红素介导的肝心轴在db/db小鼠心肌pyroptosis中的作用
Jiaxin Gu,Yadong Tang,Chunnan Liu et al.
Jiaxin Gu et al.
Diabetes, a systemic metabolic disorder, often involves multi-organ interactions in its complications. Although the pathogenesis of diabetic cardiomyopathy (DCM) is complex, the role of the liver in this process remains unclear. Using the d...
Eileen Y Su,Samantha Jones,Benjamin R Tollitt et al.
Eileen Y Su et al.
Exposure to microgravity leads to severe skeletal muscle atrophy, particularly in muscles that act to maintain posture against gravity, and results in significant reductions in muscle mass, cross-sectional area, and contractile force. This ...