The Metabolite indole-3-acetic acid of Bacteroides ovatus ameliorates ovariectomy-induced bone loss by activating AhR and inhibiting oxidative stress [0.03%]
脱氧核糖核酸菌卵酰亚胺-3-乙酸通过激活芳烃受体和抑制氧化应激缓解卵巢切除引起的骨质流失
Peng Cui,Haojie Zhang,Tao Hu et al.
Peng Cui et al.
Postmenopausal osteoporosis represents a systemic skeletal condition distinguished by diminished bone mass and heightened skeletal fragility. Emerging evidence has highlighted a significant relationship between bone metabolism and disturban...
VBIT-4 attenuates diabetes-associated cardiovascular mitochondrial dysfunction and ROS production in a mouse model of diabetes and hyperlipidemic cellular assays [0.03%]
基于糖尿病和高脂血症的小鼠模型及细胞损伤模型研究VBIT-4对糖尿病相关心血管线粒体功能障碍和ROS产生的缓解作用
Konstantin N Belosludtsev,Anna I Ilzorkina,Dmitriy A Khurtin et al.
Konstantin N Belosludtsev et al.
Mitochondrial dysfunction and oxidative stress are primary cellular factors in the development of diabetes mellitus and its associated cardiovascular complications. Targeting these processes represents a potential therapeutic strategy. Volt...
Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress [0.03%]
三氯蔗糖通过线粒体核糖体蛋白L12介导的线粒体核糖体应激促进心脏氧化代谢重塑
Ying Sun,Hualing Zhai,Junxue Wang et al.
Ying Sun et al.
Mitochondrial redox imbalance and defective oxidative phosphorylation are central features of lipotoxic cardiac injury, but whether diet-related chemical exposures perturb cardiomyocyte mitochondrial gene-expression machinery remains unclea...
Heat stress promotes myocardial injury and ventricular arrhythmia through DRP1-mediated mitochondrial dysfunction [0.03%]
热应激通过DRP1介导的线粒体功能障碍促进心肌损伤和室性心律失常
Jie Xiang,Jiang Han,Jiaru Cao et al.
Jie Xiang et al.
Background: With global warming, extreme summer heat has led to a higher morbidity and mortality of heat stroke (HS). Although heat stress has been linked to arrhythmias and cardiomyocyte injury, the specific molecular me...
Decyl-riboflavin: membrane-targeted lipophilic photosensitizer for lipid peroxidation and phototoxicity in HeLa cells under blue light irradiation [0.03%]
癸基核黄素：一种膜定位长脂溶性光敏剂，用于蓝光照射下HeLa细胞中的脂质过氧化和光毒性作用
Carlos A Ardila Padilla,M Sol Uribe Mayor,Macarena Dillon et al.
Carlos A Ardila Padilla et al.
Photodynamic therapy (PDT) exploits the controlled generation of reactive species to selectively destroy target cells, offering a minimally invasive alternative to conventional cancer and antimicrobial treatments. A key determinant of PDT e...
A multifunctional injectable hydrogel co-delivering GDF6 and MnO2 nanozymes alleviates intervertebral disc degeneration by mitigating oxidative stress and promoting anabolic repair [0.03%]
一种多用途可注射水凝胶联合递送GDF6和MnO2纳米酶，通过减轻氧化应激和促进合成代谢修复来缓解椎间盘退变
Chao Wei,Qin Tang,Yanlin Tan et al.
Chao Wei et al.
Intervertebral disc degeneration (IDD) is a primary cause of low back pain, characterized by cell loss, extracellular matrix (ECM) degradation, and a harsh microenvironment with excessive oxidative stress, creating an urgent need for regene...
Hispidulin Ameliorates Androgenetic Alopecia by Inhibiting Dermal Papilla Cell Ferroptosis via TRPML1 Channel Activation [0.03%]
黄酮化合物Hispidulin通过激活TRPML1通道抑制毛乳头细胞铁死亡从而改善雄激素性脱发
Xiaofan Jin,Hongyan Zhang,Yetan Shi et al.
Xiaofan Jin et al.
Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by progressive follicular miniaturization and dihydrotestosterone (DHT)-induced dysfunction of dermal papilla cells (DPCs). While oxidative stress is involved, the...
Corrigendum to "Selenium nanoparticles alleviate ulcerative colitis by regulating macrophage mitochondrial dynamics" [Free Rad. Biol. Med. 254 (2026) 323-341] [0.03%]
关于“硒纳米颗粒通过调节巨噬细胞线粒体动力学缓解溃疡性结肠炎”的勘误[自由基生物医学和医学254（2026）323-341]
Jiajing Chang,Xiaonan Zeng,Runan Zhang et al.
Jiajing Chang et al.
Physiologically relevant oxygen tensions reshape anticancer responses under oxidative stress-permissive culture conditions [0.03%]
生理学相关的氧气张力在氧化应激容许培养条件下重塑抗癌症反应
Magdalena Mielczarek-Puta,Dagmara Otto-Ślusarczyk,Barbara Żyżyńska-Granica et al.
Magdalena Mielczarek-Puta et al.
Tumor hypoxia is a hallmark of solid malignancies and an important determinant of therapeutic response; however, most in vitro studies are still performed under atmospheric oxygen conditions that poorly reflect physiological tissue oxygenat...
A redox homeostasis-modulating protective strategy for pancreatitis: Selenoprotein W modulates Keap1/Nrf2/PPARγ/NF-κB interaction to alleviate pancreatic injury [0.03%]
一种调节红氧平衡的防治急性胰腺炎策略：硒蛋白W通过调控Keap1/Nrf2/PPARγ/NF-κB信号轴防治胰腺炎
Yiwen Zhang,Jiawei Wu,Yihan Chang et al.
Yiwen Zhang et al.
Pancreatitis is a severe digestive disorder that poses a serious threat to human health, with a continuously increasing mortality rate. Clinical treatment options remain limited, and the key therapeutic targets are still unclear. Selenoprot...