Targeting pyroptosis in tauopathies: A redox-driven axis of neuroinflammation and neurodegeneration [0.03%]
针对tau蛋白病的焦亡作用：一种由氧化还原反应驱动的神经炎症和神经退行性病变轴心
E Alonso-López,I Silva-Llanes,E Díez-Tejedor et al.
E Alonso-López et al.
Tauopathies encompass a diverse group of neurodegenerative disorders characterized by abnormal TAU accumulation, synaptic dysfunction, neuroinflammation, and progressive neuronal loss. Beyond its role as a pathological hallmark, increasing ...
Raddeanin A induces ferroptosis by targeting VEPH1 in a cisplatin-resistant epithelial ovarian cancer cell line [0.03%]
拉达汀A通过靶向VEPH1诱导顺铂耐药性卵巢癌细胞系发生铁死亡
Huaqiu Li,Wenxiu Xing,Yuyuan Dai et al.
Huaqiu Li et al.
Ovarian cancer (OC) is a fatal female malignancy, and Cisplatin resistance severely impacts the clinical management of epithelial ovarian cancer (EOC), the most prevalent histological subtype accounting for over 90% of cases. Exploration of...
Inhibitory mechanism of thrombin (FIIa) by garlic-derived H2S: persulfidation cleavage of the Cys42-Cys58 disulfide bond triggers FIIa cascade inactivation [0.03%]
大蒜衍生的H2S通过硫醇过硫酸化裂解二硫键抑制凝血酶(FIIa)的作用机制：Cys42-Cys58二硫键的断裂触发FIIa级联失活
Meiyi Du,Lili Zhou,Yilian Lian et al.
Meiyi Du et al.
Thrombin (FIIa) is a pivotal serine protease in the coagulation cascade. Its aberrant activation drives pathological thrombosis, myocardial infarction, and stroke. Although garlic-derived sulfur compounds are known for cardiovascular protec...
James N Cobley,Anna Noble,Matthew Guille
James N Cobley
Cysteine oxidation generates biologically important proteoforms that are difficult to directly resolve using conventional immunoblot or peptide-based mass spectrometry workflows. For a protein containing R cysteine residues, the number of t...
Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system [0.03%]
双酚A通过氧化应激-脂质代谢重组驱动甲状腺癌的发生发展：黄酮类衍生物纳米胶束递送系统逆转治疗研究
Jiwang Liang,Boying Liu,Ming Sun et al.
Jiwang Liang et al.
Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, has been increasingly implicated in thyroid carcinogenesis, yet the links between redox imbalance and metabolic alterations remain incompletely defined. Here, we combined LC-MS/M...
CD36 serves as a potential drug-target to alleviate inflammation in atherosclerosis via leonurine-mediated blockade of its activation pocket [0.03%]
CD36可通过穿心莲内酯介导的激活空腔阻断作为潜在药物靶点缓解动脉粥样硬化炎症反应
Ge Lin,Ai-Qiu Chi,Sheng-Yang Cai et al.
Ge Lin et al.
Scavenger receptor B3/differentiation cluster 36 (SCARB3/CD36) has been established as a fatty acid transporter and genetic deficiency of CD36 in mice models shows decreased uptake of oxidized low-density lipoprotein (oxLDL) and reduced ath...
Heme oxygenase-1-enriched tolerogenic dendritic cell-derived exosomes attenuate lupus nephritis by restoring immune balance and iron homeostasis [0.03%]
富集血红素氧合酶1的耐受性树突状细胞源外泌体通过恢复免疫平衡和铁稳态来减轻狼疮性肾炎
Zhouhang Xing,Jinlin Yang,Huan Zhang et al.
Zhouhang Xing et al.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by chronic inflammation, oxidative stress, and multi-organ damage, with lupus nephritis (LN) constituting a major cause of morbidity and mortality. Dysr...
Heme oxygenase-1 attenuates sepsis-associated acute lung injury by suppressing the CREB3/ARF4 signaling pathway to mitigate Golgi stress in macrophages [0.03%]
血红素氧合酶1通过抑制CREB3/ARF4信号通路减轻巨噬细胞高尔基应激来缓解脓毒症相关急性肺损伤
Chang Kong,Yuan Zhang,Xiangyun Li et al.
Chang Kong et al.
Sepsis-associated acute lung injury (S-ALI) represents a significant clinical challenge due to its high incidence and mortality rates. Macrophages play a central and dual role in the pathogenesis of S-ALI, they serve as a critical component...
CuO-NPs suppress esophageal squamous cell carcinoma by altering oxidant-dependent energy metabolism, leading to mitophagy [0.03%]
CuO-NPs通过改变依赖氧化物的能量代谢来抑制食管鳞状细胞癌，导致自噬 mitochondria
Yue Liu,Xiying Yu,Xiaowu Zhang et al.
Yue Liu et al.
Nanoparticles coupled with metals hold great promise for biomedical applications. While previous studies have shown the cytotoxic effects of copper oxide nanoparticles (CuO-NPs) on esophageal squamous cell carcinoma (ESCC), the underlying m...
SESN2 suppresses ferroptosis in polycystic ovary syndrome by maintaining PRDX6 K209 lactylation [0.03%]
SESN2通过维持PRDX6 K209乳酰化在多囊卵巢综合征中抑制铁死亡
Ying-Ying Li,Ning Xu,Xiao-Yi Gu et al.
Ying-Ying Li et al.
Polycystic ovary syndrome (PCOS) is a prevalent and heterogeneous endocrine-metabolic disorder affecting women of reproductive age, characterized by elevated androgen levels, disrupted ovulation, and polycystic ovarian changes. Increasing e...