Diet-induced hepatic and mitochondrial lipid remodeling engages one-carbon metabolism under preserved mitochondrial function [0.03%]
饮食诱导的肝和线粒体脂质重塑在保持线粒体功能的情况下参与一碳代谢
Fabrizia Carli,Sara Guerra,Ines Mateus et al.
Fabrizia Carli et al.
Background: Diets rich in saturated fat and sugar drive hepatic steatosis, yet their impact on mitochondrial lipid composition and function remains poorly understood. We investigated how steatotic diets reprogram phosphol...
Mitochondrial sulfide oxidation and persulfidation in mesenchymal stromal cell osteogenesis: Redox flux control as a unifying framework [0.03%]
成纤维细胞生长因子21在小鼠体内的作用机制研究：红氧核反应通量控制作为一个统一框架中的线粒体硫化物氧化和过硫酸盐的作用以及间质干细胞成骨过程中的作用机制研究
Davide Ciaramellano,Luigi Brunetti,Bruna Sinjari et al.
Davide Ciaramellano et al.
Hydrogen sulfide (H2S) regulates mitochondrial metabolism and thiol-dependent redox signaling. Central to its biological activity is mitochondrial sulfide oxidation, initiated by sulfide:quinone oxidoreductase (SQOR), which couples H2S cata...
Myeloperoxidase (MPO) mediates LPS-induced mitophagy in murine macrophages through AMPK/ULK1 pathway [0.03%]
髓过氧化物酶(MPO)通过AMPK/ULK1信号通路介导脂多糖诱导的巨噬细胞线粒体自噬作用
Wei Lin,Yan Zeng,Jia Li et al.
Wei Lin et al.
GLUL deficiency causes sperm acrosome defects and male infertility via influencing redox balance in mice [0.03%]
GLUL基因缺陷通过影响小鼠氧化还原稳态引起精子顶体异常和雄性不育
Mengyuan Lin,Yangkun Feng,Yun Zhang et al.
Mengyuan Lin et al.
Glutamate-ammonia ligase (GLUL) catalyzes the syntheses of glutamine, as the antioxidant that has been shown to influence sperm quality in mammals. Research on the precise functions of the GLUL gene during spermatogenesis has been constrain...
GpoA glutathione peroxidase links oxidative stress response, antibiotic persistence, and virulence in Streptococcus pneumoniae [0.03%]
GpoA型谷胱甘肽过氧化物酶将氧化应激反应、抗生素休眠和毒力联系在一起的机制研究——以肺炎链球菌为模型
V E Zappia,M Hernandez-Morfa,L Raya-Plasencia et al.
V E Zappia et al.
Glutathione peroxidases are conserved enzymes found in prokaryotic and eukaryotic organisms that reduce H2O2 to protect cells from oxidative stress damage. Here, we identified and characterized the GpoA glutathione peroxidase of Streptococc...
SLC25A48 promotes colorectal cancer growth by enhancing mitochondrial respiration and conferring ferroptosis resistance [0.03%]
SLC25A48通过增强线粒体呼吸和赋予铁死亡抗性来促进结直肠癌生长
Zhen Wang,Jinghu He,Jifu E et al.
Zhen Wang et al.
Accumulating evidence indicates that mitochondrial dysfunction is a hallmark of cancer. Nonetheless, the mechanisms linking mitochondrial dysfunction to cancer progression remain largely elusive. SLC25A48 was recently recognized as a transp...
ZIP4 protects against CCl4-induced liver fibrosis by regulating zinc homeostasis, oxidative stress, and ferroptosis [0.03%]
ZIP4通过调节锌稳态、氧化应激和铁死亡保护肝脏四氯化碳致肝纤维化
Jiali Luo,Zhuoran Yu,Junling Gao et al.
Jiali Luo et al.
Liver fibrosis is a progressive pathological process driven by chronic liver injury, with limited effective therapies. Zinc transporter ZIP4 (SLC39A4) is critical for zinc homeostasis, but its role in liver fibrosis remains unclear. Here, w...
Advanced oxidation protein products exacerbate osteoarthritis progression by disrupting stress granules assembly via endoplasmic reticulum stress [0.03%]
先进氧化蛋白产物通过内质网应激破坏压力颗粒组装从而加重骨关节炎进展
Weihao Jiang,Qi Wang,Xv Zhang et al.
Weihao Jiang et al.
Recent studies indicate that levels of Advanced Oxidation Protein Products (AOPPs) in the synovial fluid of osteoarthritis (OA) patients positively correlate with disease severity. AOPPs are not only biomarkers of oxidative damage but also ...
DLAT sustains redox homeostasis and prevent colorectal cancer from ferroptosis by regulating SLC25A39-mediated mitochondrial glutathione transport [0.03%]
DLAT通过调节SLC25A39介导的线粒体谷胱甘肽转运维持氧化还原稳态并预防胶质母细胞瘤铁死亡
Kun Zhang,Xin Zhang,Chenqi Huang et al.
Kun Zhang et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with limited therapeutic options for advanced-stage patients. Here, we identify DLAT, a key enzyme in mitochondrial metabolism, as a critical driver of CRC progres...
Prolactin Drives the Pathogenic Amplification of Atopic Dermatitis by Promoting CCL17 Secretion Through Activation of the PI3K/AKT Pathway [0.03%]
泌乳素通过激活PI3K/AKT通路促进CCL17分泌从而驱动特应性皮炎的病理性放大反应
Yuanyuan Li,Zichen Li,Jiajie Chen et al.
Yuanyuan Li et al.
Background: Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disorder driven by a combination of epidermal barrier dysfunction, immune dysregulation, and psychological stress. Although neuro-endocrine-i...