NDP52-mediated autophagic degradation of CAPZA1 ameliorates intervertebral disc degeneration by suppressing cellular senescence [0.03%]
NDP52介导的自噬性降解CAPZA1通过抑制细胞衰老改善椎间盘退变
Ge-Liang Yao,Xin-Sheng Xie,Shi-Jiang Wang et al.
Ge-Liang Yao et al.
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, characterized by the progressive senescence of nucleus pulposus cells (NPCs) and extracellular matrix (ECM) catabolism. Although bulk autophagy has been implicated...
Targeting STIM1 attenuates LPS-induced cardiac dysfunction by reshaping calcium homeostasis and mitochondrial function [0.03%]
靶向STIM1通过重塑钙稳态和线粒体功能减轻LPS诱导的心脏功能障碍
Qing-Rui Wu,Li-Bo Luo,Hui Yang et al.
Qing-Rui Wu et al.
Dysregulated calcium homeostasis and mitochondrial impairment are critical factors in the pathogenesis of sepsis-induced cardiomyopathy (SICM). STIM1 is crucial for maintaining calcium homeostasis. However, whether improving STIM1-mediated ...
Early life nutrition and redox dysregulation: Implications for lifelong metabolic health [0.03%]
早期营养与氧化还原失衡：对终生代谢健康的影响
Ufuk Ersoy,Katarzyna Goljanek-Whysall,Aphrodite Vasilaki
Ufuk Ersoy
Early-life growth patterns are increasingly recognised as critical determinants of long-term health trajectories. A substantial body of evidence links suboptimal growth during early development with an elevated risk of chronic, age-related ...
A novel CYP2E1 inhibitor, 4-Methyl-5-Acetylthiazole, mitigates LPS-induced acute lung injury by suppressing macrophage-mediated inflammation and preserving mitochondria [0.03%]
一种新型CYP2E1抑制剂4-甲基-5-乙酰基噻唑通过抑制巨噬细胞介导的炎症和保护线粒体来缓解LPS诱导的急性肺损伤
Liyuan Gao,Mengyu Wang,Rui Yang et al.
Liyuan Gao et al.
Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is characterized by pulmonary edema, inflammatory cell infiltration, and alveolar epithelial damage. Here, we investigated the protective effects of 4-Methyl-5-Acetylthiazole (Q11)...
DECR1 degradation by ursolic acid alleviates vascular calcification through inhibition of NF-κB/NLRP3 signaling pathway [0.03%]
乌索酸通过抑制NF-κB/NLRP3信号通路诱导DEDCR1降解缓解血管钙化
Hongwei Yang,An Chen,Yuanzhi Ye et al.
Hongwei Yang et al.
Vascular calcification is a common pathological feature in atherosclerosis, diabetes, chronic kidney disease and aging, and is associated with increased incidence of cardiovascular events and all-cause mortality. However, effective treatmen...
Bovine serum albumin-coated metal-phenolic nanoplatform for atherosclerosis therapy via targeted delivery and inhibition of vascular smooth muscle cells proliferation [0.03%]
靶向递送和抑制血管平滑肌细胞增殖的牛血清白蛋白包被金属酚纳米平台用于动脉粥样硬化治疗
Na Li,Qiuyue Huang,Yu Liu et al.
Na Li et al.
Aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) are central drivers of atherosclerosis (AS). In this study, we developed novel metal-phenolic nanoparticles (ECG-Cu NPs) synthesized via coordination between epica...
Corrigendum to "Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-dependent mitophagy" [Free Radic. Biol. Med. (2025) 150-160] [0.03%]
关于“Sirt1通过Hif-1α去乙酰化介导的Bnip3依赖性线粒体自噬抑制来减弱坏死性肠炎”一文的勘误[Free Radic. Biol. Med. (2025) 150-160]
Lin Zhu,Mei Huang,Lu He et al.
Lin Zhu et al.
Mitochondrial metabolism as a determinant of heterogeneous platelet functional phenotypes: Implications for antiplatelet resistance [0.03%]
线粒体代谢在异质血小板功能表型中的决定作用：对抵抗抗血小板药物的启示
Camila Velandia Franco,Ramiro Araya-Maturana,Eduardo Fuentes
Camila Velandia Franco
Platelets are increasingly recognized as a heterogeneous circulating cell population whose functional behavior cannot be fully explained by receptor-agonist signaling alone; instead, their bioenergetic state emerges as a molecular determina...
Sex-Specific lipid peroxidation profile and clinical features in a cognitive impairment cohort [0.03%]
一项认知障碍队列中的性别特异性脂质过氧化特征及临床表现
Laura Ferré-González,Carmen Peña-Bautista,Marina López-Nogueroles et al.
Laura Ferré-González et al.
Background: Alzheimer's disease (AD) displays a sex imbalance; women represent two-thirds of cases and often progress faster. Lipid peroxidation contributes to AD neurotoxicity from the oxidation of fatty acids can. Howev...
Neutrophil-derived reactive oxygen species and bystander tissue damage in inflammatory bowel disease [0.03%]
炎症性肠病中中性粒细胞源性活性氧和旁观者组织损伤
Ji Yeon Kim,Sean P Colgan,Ian M Cartwright
Ji Yeon Kim
Neutrophils (PMNs) are indispensable effectors of innate immunity whose oxidative and proteolytic capabilities permit rapid microbial containment at mucosal surfaces. Nowhere is this more functionally consequential than in the gastrointesti...