Erythropoietin signaling regulated by Rab26 attenuates sepsis-associated lung injury by suppressing macrophage ferroptosis via enhanced mitophagy [0.03%]
由Rab26调控的促红细胞生成素信号通过增强线粒体自噬抑制巨噬细胞铁死亡从而减轻脓毒症相关性肺损伤
Daohui Gong,Zhihao Zhu,Heng Qin et al.
Daohui Gong et al.
Macrophage ferroptosis contributes to sepsis-associated acute lung injury (ALI); however, its upstream regulatory mechanisms remain poorly understood. Here, using a cecal ligation and puncture (CLP) murine sepsis model, we observed that mac...
Senp1 knockdown alleviates neuronal pyroptosis after subarachnoid hemorrhage by enhancing PINK1-mediated mitophagy [0.03%]
Senp1敲低通过增强PINK1介导的线粒体自噬缓解蛛网膜下腔出血后的神经元焦亡
Yinrui Ma,Haibo Long,Han Xiong et al.
Yinrui Ma et al.
Backgrounds: Subarachnoid hemorrhage (SAH) is a critical condition in neurosurgery, and the severity of early brain injury (EBI) plays a pivotal role in determining patient outcomes. Recent studies have demonstrated that ...
GCSH promotes MASH progression by regulating cuproptosis through the glycine-GSH metabolic pathway [0.03%]
GCSH通过调控甘氨酸-GSH代谢途径调节铜死亡促进MASH进展
Xuan Fu,Yunmeng Li,Jing Chen et al.
Xuan Fu et al.
Background and objectives: Cuproptosis, a recently identified form of programmed cell death, has an unclear role in the context of metabolic dysfunction-associated steatohepatitis (MASH). This study aims to elucidate the ...
Taurine Attenuates High-Fat High-Sugar Diet-Induced Endoplasmic Reticulum Stress-Mediated Hepatocyte Apoptosis [0.03%]
牛磺酸通过减轻内质网应激介导的肝细胞凋亡缓解高糖高脂诱导的肝脏损伤
Shumei Lin,Yuwen Song,Xinxin Wang et al.
Shumei Lin et al.
High-fat and high-sugar diets lead to fat deposition and metabolic disorders in mammalian livers, causing chronic liver disease. The effect of high fat and high sugar on hepatocyte function is closely related to endoplasmic reticulum stress...
AKR1C3-Driven Restoration of Tetrahydrobiopterin Synthesis in Cellular Sepiapterin Reductase Deficiency [0.03%]
AKR1C3介导的细胞型sepiapterin还原酶缺乏症中四氢生物蝶呤合成恢复机制研究
James Woodcock,Sidhartha Tan,Jeannette Vasquez-Vivar
James Woodcock
Sepiapterin reductase (SPR) catalyzes several key steps in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases and aromatic amino acid hydroxylases, and therefore for neurotransmitter production. ...
Free Nε-(carboxymethyl)-lysine promotes diabetic kidney disease progression via RAGE/NF-κB/NLRP3 pathway-mediated podocyte PANoptosis [0.03%]
Nε-（羧甲基）赖氨酸通过RAGE/NF-κB/NLRP3途径介导的足细胞PANoptosis促进糖尿病肾脏疾病进展
Lu Zhang,Lu Chen,Wenzhe Guo et al.
Lu Zhang et al.
Diabetic kidney disease (DKD) is the major cause of end-stage renal disease worldwide. PANoptosis, a newly identified form of inflammatory cell death, is closely associated with DKD development, though its mechanism in DKD is still uncertai...
LMT328, a sulfiredoxin inhibitor, induces preferential cancer cell death and tumor regression via oxidative stress [0.03%]
硫铁蛋白抑制剂LMT328通过氧化应激诱导癌细胞选择性死亡和肿瘤消退
Gong-Rak Lee,Minjeong Kwon,Taehee Kim et al.
Gong-Rak Lee et al.
Cancer cells are more susceptible to oxidative damage due to their reliance on tightly regulated redox homeostasis. Sulfiredoxin (Srx) is an antioxidant enzyme that restores hyperoxidized peroxiredoxins and contributes to cellular redox reg...
Targeted delivery of nebivolol via lactoferrin-modified liposomes inhibits NEK7-mediated pyroptosis to ameliorate inflammatory bowel disease [0.03%]
人乳铁蛋白修饰载奈必洛尔脂质体通过靶向抑制NEK7介导的焦亡改善肠炎性疾病
Hengchang Yao,Lichao Yang,Yawei Zhang et al.
Hengchang Yao et al.
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder where pyroptosis of intestinal epithelial cells, driven by the NEK7/NLRP3 axis, is a key pathological feature. This study aimed to identify a novel inhibitor of NIMA-relate...
Sesamol reprograms mitochondrial dysfunction and metabolic signaling to rescue endothelial degeneration in Fuchs' endothelial corneal dystrophy [0.03%]
sesame醇通过重新编程线粒体功能障碍和代谢信号来拯救Fuchs角膜内皮 dystrophy的内皮退化
Divyani Nayak,Ramaraj Kannan,Sharon D&#x;Souza et al.
Divyani Nayak et al.
Purpose: Fuchs' endothelial corneal dystrophy (FECD) is a progressive corneal disease characterized by loss of corneal endothelial cells (CEnCs), eventually leading to blindness. Though mitochondrial dysfunction remains t...
Vitamin D Receptor/Sirtuin 3 Pathway Mediates the Cardioprotective Effects of Aerobic Exercise in Diabetic Mice [0.03%]
有氧运动通过维生素D受体/沉默信息调节因子3通路介导糖尿病小鼠心脏保护作用
Xiao-Ning Cui,Chao Li,Yi-Hua Qin et al.
Xiao-Ning Cui et al.
Aerobic exercise ameliorates diabetic cardiomyopathy (DCM) by improving myocardial mitochondrial function; however, the underlying mechanisms remain unclear. Vitamin D alleviates DCM by upregulating vitamin D receptor (VDR) expression, and ...