Metabolic energy expenditure in human blood long-lived neutrophils reprogrammed with inflammatory cytokines [0.03%]
人血长寿命中性粒细胞用炎性细胞因子重编程后的代谢能量消耗量
Yann Breton,Jules Gignac,Tân Khoa Lam et al.
Yann Breton et al.
The development of new analytical tools has revealed the heterogeneity of neutrophils in healthy and diseased subjects. Knowledge of this heterogeneity has led to the identification, in healthy individuals, of a minor subset of blood neutro...
ROS, identified as a driver for fibroblast activation, can be counteracted by glucocorticoid in LINC00605-dependent GMD machinery [0.03%]
ROS可通过LINC00605依赖性GMD通路被糖皮质激素拮抗而抑制成纤维细胞活化
Huayu Zhu,Liang Zhu,Jiarui Zhang et al.
Huayu Zhu et al.
Fibroblast-to-myofibroblast transformation embodies a central facet of fibroblast activation, evidenced by elevated α-SMA levels and increased extracellular matrix synthesis. While excessive reactive oxygen species (ROS) are traditionally ...
TSPO integrates redox and immune homeostasis in dermal fibroblasts to restrain vitiligo pathogenesis [0.03%]
TSPO整合皮肤成纤维细胞中的氧化还原和免疫稳态以抑制白癜风发病机制
Jinpeng Lv,Chuanwei Yin,Wenhao Yu et al.
Jinpeng Lv et al.
Vitiligo is a chronic depigmenting disorder characterized by oxidative stress-driven melanocyte loss and T cell-mediated immune activation. While melanocytes and keratinocytes have been extensively studied, the contribution of dermal fibrob...
Polystyrene nanoplastics drive neuronal senescence via PP2A-B56γ-targeted p-Ebp1Ser335 dephosphorylation-mediated ribosome biogenesis dysfunction [0.03%]
聚苯乙烯纳米塑料通过PP2A-B56γ靶向去磷酸化p-Ebp1Ser335诱导核糖体生物发生障碍从而驱动神经元衰老
Yun-Lu Gao,Ming-Zhu Wang,Lei-Lei Wang et al.
Yun-Lu Gao et al.
Nanoplastics (NPs) exhibit neurotoxicity, yet the precise molecular mechanisms remain elusive. In this study, we established a human-relevant polystyrene nanoplastics (PS-NPs, 50 mg kg-1) oral exposure model in C57BL/6 mice in vivo and a ne...
Macrophage TRPML1 ameliorates post-myocardial infarction inflammation by blocking VDAC1 oligomerization to prevent ferroptosis and cGAS-STING activation [0.03%]
巨噬细胞TRPML1通过阻止VDAC1寡聚化来缓解心肌梗死后炎症以预防铁死亡和cGAS-STING激活
Xiuye Zhao,Jia Wang,Zhenru Wang et al.
Xiuye Zhao et al.
Precise modulation of the inflammatory response is critical for clearing damaged cardiomyocytes and promoting tissue regeneration after myocardial infarction (MI). Transient receptor potential mucolipin 1 (TRPML1) is an endo/lysosomal catio...
The role of 3-mercaptopyruvate sulfurtransferase in colorectal cancer progression and tumor angiogenesis [0.03%]
3-巯基丙酸硫转移酶在结直肠癌进展和肿瘤血管生成中的作用
Katie C Rouse,Gábor Törő,Peter Szaniszlo et al.
Katie C Rouse et al.
Research from our group and others suggests that 3-mercaptopyruvate sulfurtransferase (3-MST) regulates endothelial cell (EC) function by modulating angiogenic and bioenergetic responses and by stimulating colorectal cancer (CRC) cell proli...
Oxidative stress inhibits milk fat production by p38 MAPK-Cebpα-Acsl6 axis in mouse mammary gland [0.03%]
氧化应激通过p38MAPK-C/EBPα-Acsl6轴抑制小鼠乳腺脂肪生成
Xiaoxue Wang,Jiadi Su,Jing Gao et al.
Xiaoxue Wang et al.
The high incidence of oxidative stress in mammals during lactation affects mammary gland health, milk yield, and milk quality. However, the molecular mechanisms underlying oxidative stress-induced mammary gland dysfunction remain unclear. T...
Difenoconazole impairs male reproductive function by inducing spermatogenic ferroptosis via the Wnt/β-catenin/NCOA4-mediated ferritinophagy axis [0.03%]
difenoconazole通过Wnt/β-catenin/NCOA4介导的ferritinophagy轴诱导精子发生性铁死亡从而损害雄性生殖功能
Xiangqin Zheng,Qitong Guo,Runchang Wang et al.
Xiangqin Zheng et al.
Difenoconazole (DFZ), a widely used triazole fungicide, may pose a potential risk to male reproductive health, although its mechanistic basis in mammals remains incompletely understood. This study assessed DFZ-induced testicular injury thro...
TRIM16 attenuates TDP43-mediated oxidative injury by coordinating Nrf2 activation and TFR1 autophagic degradation [0.03%]
TRIM16通过协调Nrf2激活和TFR1自噬降解来缓解TDP43介导的氧化损伤
Qiuyu Chen,Yujun Zhou,Yuchen Peng et al.
Qiuyu Chen et al.
TAR DNA-binding protein 43 (TDP43) aggregation is a well-established pathological hallmark of amyotrophic lateral sclerosis (ALS) and related neurodegenerative disorders, contributing significantly to oxidative stress and neuronal injury. H...
Corrigendum to "Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer" [Free Radic. Biol. Med. 43 (2007) 289-299] [0.03%]
关于“法莫替丁在乙醇诱导的急性胃溃疡保护期间通过下调基质金属蛋白酶-9而发挥的新作用”的勘误([自由基生物与医学杂志][43(2007),289-299])
Laishram Pradeepkumar Singh,Parag Kundu,Krishnendu Ganguly et al.
Laishram Pradeepkumar Singh et al.