Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults [0.03%]
Nrf2激活可改善血管内皮功能并预防年轻人和老年人在不使用情况下的血管功能障碍
Nicholas A Carlini,Brady E Hanson,Bradley A Ruple et al.
Nicholas A Carlini et al.
Aging and physical inactivity/disuse contribute to cardiovascular disease, which is attributable, in part, to vascular endothelial dysfunction associated with impaired nuclear-factor erythroid 2-related factor 2 (Nrf2) signaling. However, t...
The protective role of aldo-keto reductase family 1 member A1 in kidney allograft injury: beyond S-nitrosylation [0.03%]
醛酮还原酶家族1成员A1在肾脏移植损伤中的保护作用：超越S-亚硝基化作用
Yong-Liang Tsai,Ying-Ming Liou,Chuan-Mu Chen et al.
Yong-Liang Tsai et al.
Aldo-keto reductase family 1 member A1 (AKR1A1) is a nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzyme that catalyzes the reduction of aldehydes to alcohols. In this study, we investigated whether AKR1A1 acts as a context...
FMO1 disrupts mitochondrial functional homeostasis through ROS-mediated mechanisms to drive chondrocyte senescence and hypertrophy [0.03%]
FMO1通过ROS介导的机制破坏线粒体功能稳态以驱动软骨细胞衰老和肥大
Ruohui Tang,Debin Guo,Shidan Li et al.
Ruohui Tang et al.
Objective: The induced membrane technique is a clinical strategy for managing large bone defects, which relies on endochondral ossification. However, the metabolic mechanisms regulating this process remain largely unchara...
Plasma glycine decelerates biological aging via the redox-inflammatory axis: A large-scale study modulated by sex and dietary patterns [0.03%]
血浆甘氨酸通过红氧化-炎症途径缓解生物衰老：一项大规模研究发现性别和饮食模式的调节作用
Huan Xu,Sijia Pan,Haitao Qi et al.
Huan Xu et al.
Background: Glycine serves as a critical substrate for glutathione synthesis and a critical modulator of redox homeostasis. However, whether plasma glycine is associated with biological aging, and the underlying interplay...
Corrigendum to "Redox-dependent suppression of ATF3 impairs steroid sensitivity in asthma through MKP-1/p38 MAPK signaling" [Free Radic. Biol. Med. 243 (2026) 1-15] [0.03%]
关于"红氧位点依赖性抑制ATF3通过MKP-1/p38MAPK信号传导损害哮喘的类固醇敏感性"[自由半径。生物医学。医学。 243（2026）1-15]的勘误表
Jinxiu Li,Lei Zhao,Yali Qiu et al.
Jinxiu Li et al.
YOD1 Regulates Neuronal Mitochondrial Unfolded Protein Response Activation by Deubiquitinating DNAJA1 After Subarachnoid Hemorrhage [0.03%]
YOD1通过去泛素化DNAJA1调节蛛网膜下腔出血后的神经元线粒体未折叠蛋白反应激活
Xi Liu,Bixi Gao,Lei Bai et al.
Xi Liu et al.
Background: Mitochondrial dysfunction plays a critical role in early brain injury (EBI) following subarachnoid hemorrhage (SAH) and represents a promising therapeutic target.The mitochondrial unfolded protein response (UP...
Salubrinal-activated integrated stress response protects against doxorubicin-induced cardiotoxicity via activating transcription factor 4-mediated antioxidant defense and glutathione homeostasis [0.03%]
萨鲁布林激活的综合应激反应通过活化转录因子4介导的抗氧化防御和谷胱甘肽稳态保护心脏免受阿霉素诱导的心脏毒性损伤
Sheng-Fan Wang,Hsuan-Yu Chou,Pei-Hsun Liu et al.
Sheng-Fan Wang et al.
Doxorubicin is an effective chemotherapeutic agent; however, its use is limited by cardiotoxicity. Mitochondrial dysfunction is a central driver of doxorubicin-mediated cardiotoxicity. The role of the integrated stress response (ISR), a mit...
Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant [0.03%]
R239C突变体的GFAP表达导致溶酶体功能障碍、抗氧化能力下降以及修复功能受损
Elena Hernández-Gerez,Nuria Goya-Iglesias,Álvaro Viedma-Poyatos et al.
Elena Hernández-Gerez et al.
Intermediate filaments are critical regulators of cell responses and organizers of cellular structures. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that provides structural and functional support to astrocytes...
An integrated study of gut microbiota and serum metabolites in T2DM-ED rats after fecal microbiota transplantation [0.03%]
粪菌移植后T2DM-ED模型大鼠肠道菌群与血清代谢组的整合研究
Cheng Cheng,Lei Zheng,Xingjun Bao et al.
Cheng Cheng et al.
Erectile dysfunction (ED) is a highly prevalent and refractory complication of type 2 diabetes mellitus (T2DM), with penile cavernosal dysfunction, inflammation, apoptosis, and fibrosis as core pathological features. Here we identify gut mi...
Ski promotes KLF4 expression to drive astrocyte senescence through the JAK2/STAT3 pathway after spinal cord injury in rats [0.03%]
Ski通过JAK2/STAT3信号促进KLF4表达诱导脊髓损伤后星形胶质细胞衰老的作用及机制研究
Yongqiang Shi,Kairong Song,Wenming Zhou et al.
Yongqiang Shi et al.