SKQ1 promotes tumor cell apoptosis by directly interacting with NDUFV2 and inducing superoxide production [0.03%]
SKQ1通过直接与NDUFV2相互作用并诱导超氧化物产生来促进肿瘤细胞凋亡
Xiaojian Tong,Meng Gao,Lingke Qu et al.
Xiaojian Tong et al.
SKQ1, a mitochondria-targeted antioxidant composed of triphenylphosphonium (TPP+) and plastoquinone, has been reported to exhibit antitumor potential; however, its underlying mechanism of action and specific molecular targets remain largely...
Salvianolic acid B ameliorates metabolic dysfunction-associated steatohepatitis in mice by inhibiting hepatocyte ferroptosis via regulation of the SIRT1/p53 axis [0.03%]
通过调节SIRT1/p53轴抑制肝细胞铁死亡改善代谢功能异常相关steatohepatitis的研究
Xiaoxi Zhou,Jinxin Lv,Wei Liu et al.
Xiaoxi Zhou et al.
Background: MASH has become the most prevalent chronic liver disease worldwide. Hepatocyte ferroptosis is a key driver in the progression of MASH. Salvianolic acid B (Sal B), a natural antioxidant active ingredient, has a...
Carbon ions collapse the hypoxic lipid shield to decouple survival from redox vulnerability in NSCLC [0.03%]
碳离子可瓦解非小细胞肺癌的缺氧性脂质保护层并分离其生存与氧化还原脆弱性的关联
Ningyi Ma,Wei Hu,Yong Deng et al.
Ningyi Ma et al.
Hypoxic non-small cell lung cancer (NSCLC) cells actively remodel lipid metabolism to construct a biochemical shield against lipotoxicity and oxidative stress. This adaptation drives a unidirectional phosphatidylcholine to triacylglycerol c...
Targeting NLRP3 palmitoylation: Celastrol alleviates inflammasome activation induced by immunometabolism dysregulation in Kupffer cells [0.03%]
靶向NLRP3棕榈酰化：Celastrol通过调节枯氏细胞的免疫代谢紊乱来缓解炎性小体活化
Limei Tao,Zheng Fang,Wanshan Gu et al.
Limei Tao et al.
Protein palmitoylation, the only reversible lipid-linked post-translational modification, acts as a critical regulatory mechanism for modulating protein function and subcellular localization. However, its specific roles and underlying mecha...
Inhibition of HO-1 alleviates cardiac fibrosis by improving ferroptosis-mediated aberrant autophagy [0.03%]
HO-1抑制通过改善铁死亡介导的自噬异常缓解心脏纤维化
Chengyu Kong,Hanyu Liu,Shuxia Jiang et al.
Chengyu Kong et al.
Cardiac fibrosis is a major pathological feature of cardiovascular diseases and a key driver of ventricular remodeling and heart failure, yet effective therapeutic strategies remain limited due to incomplete mechanistic understanding. Heme ...
The IL-33/ST2 axis promotes sepsis-induced lung injury by modulating NETs formation via the ATF4/REDD1 signaling pathway [0.03%]
IL-33/ST2轴通过激活ATF4/REDD1信号通路调控NETs形成促进脓毒症诱导的肺损伤
Hongkai Dai,Yingfang Zheng,Cheng Li et al.
Hongkai Dai et al.
Background: Neutrophil extracellular traps (NETs) can mediate sepsis-induced lung injury, but the upstream regulatory mechanisms remain unclear. IL-33 is involved in neutrophil activation and may serve as an upstream regu...
Nano-selenium attenuates cadmium-induced ER-phagy through inhibition of TFEB nuclear translocation and FAM134B downregulation [0.03%]
纳米硒通过抑制TFEB核转位和降低FAM134B表达来缓解镉诱导的内质网自噬
Yun-Shuang Liang,Jia-Ying Du,Wen-Na Cai et al.
Yun-Shuang Liang et al.
Cadmium (Cd) is a well-documented environmental pollutant associated with male reproductive disorders, necessitating the urgent development of effective therapeutic agents. Nano-selenium (Nano-Se) represents an advanced selenium supplement ...
Fyn Promotes NLRP3 Inflammasome Activation in Microglia and Exacerbates Early Brain Injury Following Subarachnoid Hemorrhage [0.03%]
FHYN促进蛛网膜下腔出血后小胶质细胞NLRP3炎性体的激活并加重早期脑损伤
Kaixin Ping,Panpan Zhao,Jingyuan Zhou et al.
Kaixin Ping et al.
Background: Subarachnoid hemorrhage (SAH) is a lethal stroke subtype with high mortality. Microglia-driven neuroinflammation plays a pivotal role in early brain injury (EBI) after SAH. Xanthotoxol (Xol), a natural furanoc...
Exhaled 3-nitrotyrosine is associated with non-allergic asthma in adults from the EGEA study [0.03%]
EGEA研究中成人非过敏性哮喘与呼出的3-硝基酪氨酸有关
Eya Sahraoui,Vincent Masso,Pascale Raymond et al.
Eya Sahraoui et al.
The role of exhaled 3-nitrotyrosine (3-NT) beyond the severe asthma phenotype remains largely unexplored. Associations of exhaled 3-NT with allergy and with various asthma characteristics were studied in 792 adults from the French Epidemiol...
pH-regulated ''ON/OFF″ glucose oxidase nanoparticles for synergistic therapy and amplification of immunogenic cell death [0.03%]
pH值调控的''开/关"型葡萄糖氧化酶纳米颗粒在协同治疗和放大免疫源性细胞死亡方面的应用
Zhongmin Wang,Huayang Bai,Xiaowen Shen et al.
Zhongmin Wang et al.
Although the combination of glucose oxidase (GOx)-based starvation therapy and chemodynamic therapy (CDT) has shown great potential, the severe systemic toxicity caused by the non-specific activity of GOx in the blood circulation and the in...