YY1 Promotes Diabetic Vascular Calcification Via m6A-Binding Protein HNRNPC [0.03%]
YY1通过m６A结合蛋白HNRNPC促进糖尿病血管钙化
Bo Yang,Xiang Mao,Liqun Ren et al.
Bo Yang et al.
Background: Diabetes is one of the most common and fastest-growing diseases worldwide, and diabetic atherosclerotic calcification is a frequent and fatal complication, the underlying mechanisms of which remain unclear. In...
IL-6/STAT3 signaling drives mitochondrial oxidative phosphorylation dysfunction and AP-1 activation in fibroblasts during sepsis-induced lung injury [0.03%]
败血症诱导的肺损伤过程中, IL-6/STAT3信号驱动成纤维细胞线粒体氧化磷酸化功能障碍和AP-1活化
Xing Chen,Xingyu Jin,Hongjie Bao et al.
Xing Chen et al.
Sepsis-induced acute lung injury (ALI) and early fibrotic remodeling remain major clinical challenges with limited effective treatments. In this study, we systematically investigated the role of fibroblasts in sepsis-associated lung injury ...
Mitochondrial complex I as a master regulator of redox signaling: From structural architecture to directionality of electron transport [0.03%]
线粒体复合物I作为活性氧信号传导的主要调节者：从结构框架到电子传递的方向性
Ehsaneh Khodadadi,Bingwei Lu
Ehsaneh Khodadadi
Mitochondrial complex I (MCI) is the largest enzyme of the electron transport chain, catalyzing oxidation of NADH, reduction of ubiquinone, and translocation of protons across the inner mitochondrial membrane (IMM). In addition to driving A...
Histone lactylation exacerbates neuronal ferroptosis after traumatic brain injury: The effect of the upregulation of TNFAIP3 by mediating mitochondrial damage through the deubiquitination of ENO1 [0.03%]
组蛋白乳酰化加重创伤性脑损伤后的神经元铁死亡：通过ENOA去泛素化介导线粒体损伤上调TNFAIP3的作用
Lin Zhou,Zhicheng Xu,Xiao Hou et al.
Lin Zhou et al.
Alleviating various forms of programmed neuronal death resulting from mechanical injury has long driven the development of neurotherapeutic strategies for traumatic brain injury (TBI). This study aimed to elucidate the potential role of tum...
Multi-Omics Profiling of Oxylipins and Gene Expression in Pediatric Sarcomas Identifies Metastatic Signatures and Prognostic Models [0.03%]
儿童肉瘤的多组学氧化脂质和基因表达谱分析识别转移标志物及预后模型
D V Chistyakov,A I Nikolskaya,V O Gorbatenko et al.
D V Chistyakov et al.
Introduction: Pediatric bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive malignancies with poor prognosis in the metastatic stage. Oxylipins, bioactive lipid mediators derived from polyuns...
4-N-Furfurylcytosine, a Novel Cytosine-Derived Modulator of Mitochondrial and Redox Homeostasis to Counteract Aging: Insights from Cellular and Mouse Models [0.03%]
新型胞嘧啶衍生物4-N-糠基胞嘧啶通过调节线粒体和氧化还原稳态来对抗衰老：来自细胞和小鼠模型的启示
Agnieszka Fedoruk-Wyszomirska,Paweł Pawelczak,Marta Orlicka-Płocka et al.
Agnieszka Fedoruk-Wyszomirska et al.
Mitochondrial dysfunction and redox imbalance are key features of aging that drive cellular senescence, metabolic decline, and tissue degeneration. 4-N-furfurylcytosine (FC), a cytosine derivative with redox-modulating properties, has been ...
Yongjie Wang,Runqiu Chi,Congcong Zhang et al.
Yongjie Wang et al.
Cuproptosis is a copper-dependent regulated cell death pathway, but its connection to chromatin regulation is poorly understood. Here, we demonstrate that cuproptosis-sensitive tumor cells exhibit an "epigenetically primed" state with eleva...
Rab26 Mitigates Ferroptosis in Airway Epithelium Induced by Cigarette Smoke Through Suppression of VDAC1 Oligomerization-Mediated cGAS-STING Activation [0.03%]
Rab26通过抑制VDAC1寡聚化介导的cGAS-STING活化缓解香烟烟雾诱导的气道上皮铁死亡
Xin Tian,Wen Zhang,Zaichun You et al.
Xin Tian et al.
Background: Cigarette smoke (CS)-induced epithelial ferroptosis is a pivotal driver of airway inflammation and remodeling in chronic obstructive pulmonary disease (COPD). Although Rab26 is known to protect against inflamm...
Unveiling C1QBP: A New Guardian of Dopaminergic Neuron in Parkinson's disease by targeting ULK1 to promote mitophagy and maintain mitochondrial function [0.03%]
揭示C1QBP通过靶向ULK1促进线粒体自噬和维持线粒体功能从而成为帕金森病多巴胺能神经元的新守护者
Jing Li,Yihan Wang,Min Liu et al.
Jing Li et al.
Mitochondrial dysfunction is widely considered one of the key initiating factors leading to Parkinson's disease (PD). Mitophagy plays a critical role in maintaining mitochondrial homeostasis. Complement C1q-binding protein (C1QBP) plays a c...
NRF2 Coordinates Ferroptosis and Disulfidptosis in Dermal Papilla Cells via Redox Metabolic Reprogramming in Androgenetic Alopecia [0.03%]
NRF2通过还原代谢重编程协调雄激素性脱发乳头细胞铁死亡和二硫化物死亡
Xiaowen Mao,Wenwen Zhou,Weiyi An et al.
Xiaowen Mao et al.
Dysfunction of dermal papilla cells (DPCs) is a central feature of androgenetic alopecia (AGA), in which oxidative imbalance plays a critical role. Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular redox h...