CAND1 drives intestinal ischemia/reperfusion injury via SCFFBXO6-PKM2-mediated mitochondrial fission and apoptosis [0.03%]
CAND1通过SCFFBXO6-PKM2介导的线粒体分裂和凋亡驱动肠缺血再灌注损伤
Miaomiao Qiang,Yan Zhao,Guorong Wang et al.
Miaomiao Qiang et al.
Background: Intestinal ischemia/reperfusion (I/R) injury is a critical clinical condition associated with high mortality, in which the ubiquitin‒proteasome system (UPS) plays a pivotal pathogenic role. Cullin-associated ...
Environmental factors modulate the responsiveness and reversibility of the H2O2-induced inactivation of GAPDH [0.03%]
环境因素调节H2O2诱导的GAPDH失活的应答性和可逆性
Kirsty Boms,Sara M Jørgensen,Per Hägglund et al.
Kirsty Boms et al.
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) serves as a critical metabolic switch. GAPDH inactivation by hydrogen peroxide (H2O2) reroutes the carbon flux towards the pentose phosphate pathway to generate NADPH fo...
Redoxyme: a lightweight graphical user interface for standardized calculation of antioxidant enzyme activities [0.03%]
红氧酶：一种用于标准化计算抗氧化酶活性的轻量级图形用户界面
Geovanna Carvalho de Freitas Soares,Anna Lídia Nunes Varela,Heberty Tarso Facundo
Geovanna Carvalho de Freitas Soares
Redox imbalance results from excessive accumulation of reactive oxygen species (ROS) due to either a low removal or higher production. This imbalance plays a central role in numerous physiological and pathological processes. Accurate quanti...
Nrf1 regulates lipid metabolism through the PPAR⍺ signaling pathway and influences the fibrotic process in diabetic nephropathy [0.03%]
Nrf1通过PPARα信号通路调节脂质代谢并影响糖尿病肾病的纤维化过程
Ziying Qiu,Yanmin Zhang,Laiyu Zhu et al.
Ziying Qiu et al.
Background: In diabetic nephropathy (DN), oxidative stress disrupts normal metabolic processes, contributing to progressive kidney injury. Although Nfe2l1 (also known as Nrf1) is known to regulate oxidative stress and met...
SIRT3 regulates PRDX3 acetylation to support mitochondrial peroxide detoxification and limit oxidative stress-associated ferroptosis vulnerability [0.03%]
SIRT3通过调节PRDX3乙酰化来支持线粒体过氧化氢解毒并限制与氧化应激相关的铁死亡的脆弱性
Tiange Wang,Jun Tu,Xiangyun Wei et al.
Tiange Wang et al.
Oxidative stress disrupts mitochondrial redox homeostasis and contributes to ferroptosis-associated vulnerability, yet the molecular link between impaired mitochondrial peroxide detoxification and ferroptosis-associated vulnerability remain...
Aberrant TIMM8B alternative splicing compromises mitochondrial respiratory chain integrity and redox homeostasis [0.03%]
TIMM8B异常剪接损害线粒体呼吸链完整性和氧化还原平衡
Sang-Jin Lee,Sangsoo Lee,Kee K Kim et al.
Sang-Jin Lee et al.
Mitochondrial redox homeostasis depends on respiratory chain integrity, but whether environmental stress alters this system through alternative splicing remains poorly understood. Here, we identify aberrant TIMM8B alternative splicing as a ...
ac4C modification of PDK4 by NAT10 promotes pulmonary fibrosis by reprogramming mitochondrial dynamics in fibroblasts [0.03%]
PDK4的AC4C修饰蛋白NAT10通过重新编程成纤维细胞中的线粒体动力学促进肺纤维化
Dongyu Liu,Yanqun Li,Tianyang Liu et al.
Dongyu Liu et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder with limited therapeutic options, necessitating the identification of novel pathogenic mechanisms and therapeutic targets. Here, we report a critical role for the ...
The downregulation of PEPCK mediated cuproptosis is involved in triclosan induced reproductive damage in mouse testes via triggering ROS overproduction [0.03%]
PEPCK介导的铜死亡下调参与了三氯生诱导的小鼠睾丸生殖毒性及其促ROS过量累积作用
Yanjun Ding,Yifan Hong,Xiazhu Zhou et al.
Yanjun Ding et al.
Triclosan (TCS) is a widely used broad-spectrum antimicrobial agent that has been demonstrated to induce damage to the male reproductive system. However, the specific mechanisms of testicular injury induced by TCS are not fully understood. ...
Restoring BECN1-mediated autophagy mitigates acute lung injury caused by zinc oxide nanoparticles [0.03%]
BECN1介导的自噬恢复可缓解氧化锌纳米颗粒引起的急性肺损伤
Lejiao Mao,Meiling Tan,Xuejun Jiang et al.
Lejiao Mao et al.
Pulmonary inhalation of zinc oxide nanoparticles (ZnONPs) triggers metal fume fever in humans and acute lung injury (ALI) in animal experiments. Previous evidence suggests that autophagy is involved in the pathogenesis of ZnONPs-induced ALI...
Thiomyristoyl promotes type 2 diabetic wound healing and inhibits scarring via the PPARγ/Sirt3/SOD2 axis [0.03%]
硫默苷通过PPARγ/Sirt3/SOD2轴促进2型糖尿病伤口愈合并抑制瘢痕形成
Xiuyu Ge,Ziyue Ye,Haozhi Qin et al.
Xiuyu Ge et al.
Fibroblasts are essential for the process of wound healing. However, under diabetic conditions, they often exhibit functional impairment and fibrosis, leading to impaired healing. Currently, there are limited effective interventions for fib...