HERC2 as a Bidirectional Iron Metabolism Switch: Synergistic NCOA4 Stabilization and FBXL5 Degradation Drive Ferroptosis-Cascaded Hepatotoxicity in Nd2O3 Nanoparticles Exposure [0.03%]
HERC2作为双向铁代谢开关：NCOA4稳定和FBXL5降解的协同作用驱动Nd₂O₃纳米颗粒暴露下肝毒性的铁死亡级联反应
Sihao Liu,Weiming Du,Chengyong Sun et al.
Sihao Liu et al.
Neodymium oxide nanoparticles (NdNPs), pivotal materials in advanced manufacturing and frontier technologies, raise growing concerns due to their potential risk to environment and health risks. Epidemiological studies linked neodymium expos...
ADORA2B/ador-1 is required for multi-system transcriptional adaptation to mild hypoxia and healthspan extension in C. elegans [0.03%]
ADORA2B/ador-1在轻度缺氧下的转录适应及C. elegans健康寿命的延长中是必需的
Xavier Capó,Margalida Torrens-Mas,Guillermo Calvo-Navarrete et al.
Xavier Capó et al.
Background: Mild intermittent hypoxia is emerging as a promising strategy to enhance healthspan, but the molecular mechanisms remain poorly defined. ADORA2B, a hypoxia-inducible adenosine receptor, is known to regulate me...
SIRT5 desuccinylates ME2 to suppress oxidative stress in bovine mammary epithelial cells [0.03%]
SIRT5通过脱琥珀酰化ME2抑制牛乳腺上皮细胞的氧化应激
Shiang Sun,Qilong Yang,Xiaoxiao Liu et al.
Shiang Sun et al.
Excessive accumulation of reactive oxygen species (ROS) in mitochondria is a key factor in inducing cellular oxidative stress. NADPH serves as a critical reducing equivalent for maintaining glutathione (GSH) in its reduced state, which is e...
Multi-layered Regulatory Mechanisms and Translational Implications of Mitochondrial Redox Imbalance in Aging Stem Cells [0.03%]
衰老干细胞线粒体氧化还原失衡的多层调控机制及其转化意义
Zi Ye,Shanshan Chen,Jiali Rui et al.
Zi Ye et al.
Mitochondrial redox homeostasis is required for proper stem cell fate determination and tissue regeneration, and its dysregulation is a hallmark of aging-related stem cell dysfunction. This review systematically summarizes the multi-layered...
An inulin-based fiber-rich diet alleviates doxorubicin cardiotoxicity via the fMet-KCNE2 axis to attenuate ferroptosis and oxidative stress [0.03%]
富纤维的菊粉饮食通过fMet-KCNE2轴抑制铁死亡和氧化应激从而缓解阿霉素的心脏毒性
Jin Li,Yijie He,Yun Wu et al.
Jin Li et al.
Doxorubicin (DOX)-induced cardiotoxicity remains a major complication of anticancer chemotherapy, and there is a substantial unmet need for safe and effective preventive and therapeutic strategies. This study investigated the potential mech...
RNF10 attenuates age-related muscle atrophy by promoting p53 degradation and alleviating oxidative stress [0.03%]
RNF10通过促进p53降解和缓解氧化应激来减轻年龄相关的肌肉萎缩
Hong Yang,Yingxiao Zhang,Li Zhang et al.
Hong Yang et al.
Evidence identifies proteostasis imbalance and oxidative stress serve as fundamental pathological hallmarks of muscular atrophy, yet ring finger protein 10 (RNF10), a novel E3 ubiquitin ligase, in age-related muscular atrophy remains poorly...
Comparison of the reactivity of hypochlorous acid (HOCl) and hyposelenocyanous acid (HOSeCN) with elastase: role of amino acid modification and structural changes in loss of activity [0.03%]
次氯酸(HOCl)和低硒氰酸(HOSeCN)与弹性蛋白酶反应活性的比较：氨基酸修饰和结构变化在活性丧失中的作用的比较
Helen Hemmling,Olivia G Webber,Anna Guitart-Solanes et al.
Helen Hemmling et al.
Elastase is a serine protease that plays a key role in intracellular and extracellular neutrophil-driven immune responses. There is a synergistic relationship between elastase and myeloperoxidase (MPO), which can boost pathogen killing and ...
Shogaol triggers apoptosis and ferroptosis in Ewing sarcoma by targeting the polo-like kinase 1/nucleophosmin 1 axis [0.03%]
姜黄素类似物shogaol通过靶向polo样蛋白激酶1/核不均一型核糖核蛋白a/b轴诱导尤因肉瘤细胞凋亡及铁死亡
Zhengyu Wu,Huimou Chen,Yu Zhou et al.
Zhengyu Wu et al.
Ewing sarcoma is an aggressive pediatric bone cancer with poor prognosis, highlighting the urgent need for novel therapeutics. This study demonstrates the potent anti-tumor activity of shogaol, a bioactive compound from ginger, against Ewin...
Genetic modifiers of Friedreich's ataxia pathophysiology in Drosophila melanogaster - A systematic review and meta-analysis [0.03%]
果蝇基因修饰因子弗里德希共济失调病理生理系统的综述和元分析研究
Ravi Kant Yadav,Vishnu Swarup,Anami Ahuja et al.
Ravi Kant Yadav et al.
Friedreich's ataxia (FRDA) is a rare autosomal recessive neurodegenerative disorder caused by reduced frataxin protein levels. Depleted frataxin leads to mitochondrial dysfunction, elevated oxidative stress and progressive neurodegeneration...
Cytosolic Phospholipase A2α (PLA2G4A) Promotes Oxidative Stress-Mediated Endothelial Ferroptosis in Sepsis-Induced Acute Lung Injury [0.03%]
胞浆磷脂酶A2α（PLA2G4A）促进脓毒症急性肺损伤内皮细胞铁死亡相关氧化应激损伤
Lu Wang,Mingyu Chen,Xiaoxiao Meng et al.
Lu Wang et al.
Sepsis-induced acute lung injury (ALI) is a life-threatening syndrome characterized by the disruption of the pulmonary vascular endothelial barrier; however, the upstream lipid metabolic networks orchestrating endothelial cell death remain ...