Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models [0.03%]
ALOX15泛素化调节施万细胞及自身免疫性神经炎模型中的内质网应激反应
Jihe Song,Baichao Han,Xinshu Du et al.
Jihe Song et al.
In the pathogenesis of experimental autoimmune neuritis (EAN), Schwann cells execute critical myelination functions through their characteristic axonal ensheathment, thereby facilitating saltatory conduction via myelin sheath formation. Our...
3-Bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by a pro-oxidant mechanism [0.03%]
3-溴代丙酮酸通过促氧化机制增强急性髓系白血病的化疗效果
Joana Pereira-Vieira,Sara Granja,Sónia Pires Celeiro et al.
Joana Pereira-Vieira et al.
Acute myeloid leukemia (AML) comprises a diverse group of blood cancers with varying genetic, phenotypic, and clinical traits, making development of targeted therapy challenging. Metabolic reprogramming in AML has been described as relevant...
The glutathione system maintains the thiol redox balance in the mitochondria of fission yeast [0.03%]
谷胱甘肽系统维持裂殖酵母线粒体的硫醇氧化还原平衡
Laura de Cubas,Susanna Boronat,Montserrat Vega et al.
Laura de Cubas et al.
The thioredoxin and glutathione (GSH)-glutaredoxin electron donor pathways provide a reducing environment to the cell and maintain homeostasis of numerous redox reactions. The abundant tripeptide GSH has multiple roles, including redox buff...
Transcription factor KLF5 regulates MsrB1 to promote colorectal cancer progression by inhibiting ferroptosis through β-catenin [0.03%]
转录因子KLF5通过β-连环蛋白调节MsrB1促进结直肠癌进展并抑制铁死亡
Zhengdan Gao,Shengyong Yang,Shanshan Jiang et al.
Zhengdan Gao et al.
Methionine sulfoxide reductase B1 (MsrB1), a member of the selenoprotein family with a catalytic site containing a selenocysteine (Sec) residue, has been identified as an oncogene in colorectal cancer (CRC). However, the regulatory mechanis...
Inactivation of mitochondrial pyruvate dehydrogenase by singlet oxygen involves lipoic acid oxidation, side-chain modification and structural changes [0.03%]
单线态氧通过硫脂酸氧化、侧链修饰和结构变化使线粒体丙酮酸脱氢酶失活
Qing Gao,Per Hägglund,Luke F Gamon et al.
Qing Gao et al.
The multi-subunit pyruvate dehydrogenase complex (PDC) plays a crucial role in glucose oxidation as it determines whether pyruvate is used for mitochondrial oxidative phosphorylation or is converted to lactate for aerobic glycolysis. PDC co...
A hemicyanine-based dual-modal probe for fluorescence and mass spectrometry imaging of peroxynitrite in biosamples [0.03%]
一种用于生物样本中过氧亚硝酸盐荧光和质谱成像的半花青素衍生双模式探针
Yuejie Zhang,Jingfeng Zhang,Weiwei Tang et al.
Yuejie Zhang et al.
Peroxynitrite (ONOO-) is a highly reactive oxidant formed by the reaction of nitric oxide with superoxide. Excessive ONOO- can be produced by the body in response to multiple diseases, resulting in cell death through oxidation and nitration...
Betulinic acid protects against lipopolysaccharide and ferrous sulfate-induced oxidative stress, ferroptosis, apoptosis, and neuroinflammation signaling relevant to Parkinson's Disease [0.03%]
熊果酸通过抗氧化、抗铁死亡和抗炎作用对帕金森病模型小鼠发挥保护效应
Shivam Kumar Pandey,Anjuman Nanda,Avtar Singh Gautam et al.
Shivam Kumar Pandey et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective degeneration of dopaminergic neurons in the substantia nigra, leading to profound motor dysfunction and non-m...
Corrigendum to "Dapagliflozin protects against doxorubicin-induced nephrotoxicity associated with nitric oxide pathway-a translational study" [Free Radic. Biol. Medi. 208 (2023) 103-111] [0.03%]
达格列净对阿霉素引起的与一氧化氮通路相关的肾毒性的保护作用的勘误[自由基生物医学医学第208卷(2023年)103-111页]
Wei-Ting Chang,Chia-Chun Wu,I-Chuang Liao et al.
Wei-Ting Chang et al.
Vitamin E nomenclature [0.03%]
维生素E的命名法
Angelo Azzi,Jeffrey Atkinson,Nesrin Kartal Ozer et al.
Angelo Azzi et al.
The 3rd Vitamin E Satellite Symposium (VESS3) "100 years of vitamin E", held in Ghent, Belgium, August 2022 during the joint meeting of the Society for Free Radical Research (SFRR)-Europe branch and the Plant Oxygen Group (POG) was an occas...
Endoplasmic reticulum stress-autophagy axis is involved in copper-induced ovarian ferroptosis [0.03%]
铜诱导的卵泡铁死亡与内质网应激自噬轴有关
Tingting Wang,Qianzhuo Liu,Limin Wu et al.
Tingting Wang et al.
Copper (Cu) contamination has emerged a global public health problem due to the extensive use of Cu in industrial production and daily life. Reproductive damage resulting from Cu exposure has been particularly evident. Wilson's disease (WD)...