Ultraviolet B-induced oxidative stress drives stromal remodeling and malignant transformation of actinic keratosis via a podoplanin-C-type lectin-like receptor 2 signaling axis [0.03%]
紫外线B诱导的氧化应激通过肺泡蛋白样糖蛋白受体轴驱动光化性角化病基质重塑和恶性转化
Zuochao Yao,Lu Lu,Mengxiong Song et al.
Zuochao Yao et al.
Ultraviolet B (UVB) radiation induces oxidative stress and promotes photocarcinogenesis; however, the molecular mechanisms linking oxidative stress to the malignant transformation of actinic keratosis (AK) remain incompletely understood. He...
Low-dose ionizing radiation drives thyroid carcinogenesis via VPS53 enhanced EGFR Re-recycling [0.03%]
低剂量电离辐射通过VPS53增强EGFR重新回收促进甲状腺癌发生发展
Yuhao Liu,Lin Zhou,Jiaojiao Zhu et al.
Yuhao Liu et al.
Ionizing radiation is a confirmed independent environmental factor for thyroid cancer. Environmental and occupational exposure are exposed to low-dose ionizing radiation (LDR), which underscores the persistent need to decipher the mechanism...
Myeloid HIF-1α Couples Glycolytic Energy Supply with NCF2-Dependent Oxidative Killing to Protect Against Klebsiella pneumoniae Pneumonia [0.03%]
髓系HIF-1α介导糖酵解能量供应与NCF2依赖性杀菌作用以抵抗肺炎克雷伯菌所致的肺部感染
Yaqin Guo,Bao Meng,Rongqin Zhu et al.
Yaqin Guo et al.
Background: Hypervirulent Klebsiella pneumoniae (hvKp) induces severe pneumonia and sepsis. HIF-1α coordinates metabolic and immune responses in myeloid cells, but its role in hvKp-mediated pulmonary defense remains unde...
Manoalide targets redox-mitochondrial vulnerability to induce bioenergetic failure and suppress angiogenic activity in glioblastoma [0.03%]
二
Nan-Fu Chen,Hsiao-Mei Kuo,San-Nan Yang et al.
Nan-Fu Chen et al.
Glioblastoma (GBM) displays pronounced metabolic adaptability and resistance to cell death, largely sustained by mitochondrial redox homeostasis. Targeting redox imbalance has emerged as a promising strategy; however, the relationship betwe...
A Critical Role for Mitochondrial Dynamics in Cigarette Smoke Condensate-induced RPE Senescence [0.03%]
线粒体动力学在香烟冷凝物诱导的视网膜色素上皮细胞衰老中的关键作用
Qi Zhou,Zunyi Zhang,Yinga Wu et al.
Qi Zhou et al.
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Its pathogenesis remains incompletely understood, partly due to the complex interplay of genetic risk, aging, and environmental stressors. Cigarette sm...
Retraction notice to "Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4" [Free Radical Biol. Med. 54 (2013) 93-104] [0.03%]
撤销《Leonurine(SCM-198)通过抑制NADPH氧化酶4减弱心肌纤维化反应》[自由基生物医学,54(2013)93-104]的撤稿通知
Xin-Hua Liu,Li-Long Pan,Hai-Yan Deng et al.
Xin-Hua Liu et al.
Iron chaperones and RNA-binding proteins, PCBP1 and PCBP2, maintain hepatic iron balance and protect against ferroptosis [0.03%]
铁伴侣和RNA结合蛋白PCBP1和PCBP2维持肝脏铁平衡并防止铁死亡
Olga Protchenko,Amber J Tietgens,Eva Messager et al.
Olga Protchenko et al.
Poly rC binding proteins (PCBPs) 1 and 2 bind iron and ssDNA/RNA, acting as iron chaperones for enzyme metalation, ferritin storage, and iron toxicity prevention. Previously, we demonstrated that liver-specific PCBP1 deletion in mice increa...
Irisin Acts as an Exercise Mimetic to Alleviate Sedentary-Induced Osteoporosis by Reprogramming Macrophage-Mediated Inflammation via the HSP90-MAPK Signaling Axis [0.03%]
irisin通过HSP90-MAPK信号轴重构巨噬细胞介导的炎症来缓解久坐引起的骨质疏松症
Xiuting Xiang,Yunjun Ruan,Shiyu Feng et al.
Xiuting Xiang et al.
Sedentary behavior induces bone loss partly through chronic low-grade inflammation, presenting a critical need for novel pharmacological interventions. Irisin, a cleaved product of Fibronectin type III domain-containing protein 5 (FNDC5), h...
Proteome-wide quantitative analysis of redox cysteine in porcine uterus reveals deoxynivalenol induced oxidative stress via protein hyperoxidation [0.03%]
基于猪子宫红细胞半胱氨酸蛋白质组的氧化还原定量分析发现脱氧雪腐镰刀菌烯醇通过蛋白质过氧化造成氧化应激
Shuhao Fan,Fang Tian,Qianqian Wang et al.
Shuhao Fan et al.
Deoxynivalenol (DON), a mycotoxin produced by fungi of the genus Fusarium, is ubiquitously distributed in feed and poses a substantial threat to human and animal health. Pigs exhibit particular sensitivity to DON, which can induce reproduct...
Ginsenoside Rk1 suppresses osteosarcoma progression by coordinately activating ferritinophagy and disrupting antioxidant defense to induce ferroptosis [0.03%]
人参皂苷Rk1通过协同激活铁蛋白自噬并破坏抗氧化防御来诱导铁死亡从而抑制骨肉瘤进展
Renjin Lin,Jianlong Wu,Renpeng Fang et al.
Renjin Lin et al.
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite advances in multimodal therapy, the prognosis of metastatic or recurrent OS remains poor due to chemoresistance and limited therapeutic o...