UCP1 maintains lipid homeostasis and developmental competence through MCU-mediated mitochondrial calcium uptake in bovine oocytes [0.03%]
UCP1通过牛卵母细胞线粒体钙摄取维持脂质稳态和发育潜能
Yuwen Luo,Jun Li,Yun Wang et al.
Yuwen Luo et al.
Lipid homeostasis is essential for oocyte quality and developmental competence, and uncoupling protein 1 (UCP1) has been identified as a critical regulator of lipid metabolism in oocytes. However, the downstream molecular mechanism by which...
FDA-approved dimethyl fumarate targets thioredoxin reductase to induce apoptosis in triple-negative breast cancer [0.03%]
富马酸二甲酯通过靶向三阴性乳腺癌的硫氧还蛋白还原酶诱导细胞凋亡得美国食品药品管理局批准
Dongzhu Duan,Yali Pu,Yanru Wang et al.
Dongzhu Duan et al.
Triple-negative breast cancer (TNBC) is characterized by poor prognosis, which is closely linked to significant tumor heterogeneity and the absence of effective targeted treatments beyond conventional chemotherapy, thereby necessitating the...
Astragalin confers coordinated neuroprotection in Parkinson's disease models through modulation of neurotrophic, anti-inflammatory, and synuclein-related pathways [0.03%]
异鼠李素通过调节神经营养、抗炎和α-突触核蛋白相关途径在帕金森病模型中发挥协同神经保护作用
Jun Wang,Jie-Yu He,Qin Huang et al.
Jun Wang et al.
Parkinson's disease (PD) remains a neurodegenerative disorder without effective disease-modifying therapies, largely due to its multifactorial pathogenesis. We report that the natural flavonoid Astragalin (AST) concurrently addresses three ...
Exercise and phytochemicals as modulators of redox homeostasis in aging [0.03%]
运动和植物化学物质对衰老中氧化还原稳态的调节作用
Tinna Traustadóttir,Hashim Islam,Ethan L Ostrom
Tinna Traustadóttir
Reduced resilience to physiological stress, including impaired redox signaling, is a hallmark of aging that contributes to chronic disease risk. The transcription factor Nrf2 is widely considered a master regulator of redox homeostasis. Alt...
Integrated multi-omics profiling identifies a convergent gut-metabolic-immune signature in Alzheimer's disease [0.03%]
整合多组学分析识别出阿尔茨海默病中一致的肠道-代谢-免疫特征
Zongxin Ling,Xiaocui Xu,Yiwen Cheng et al.
Zongxin Ling et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with rising global prevalence, yet the peripheral mechanisms linking gut dysbiosis, systemic redox imbalance, and immune activation remain poorly understood. Here, we perf...
PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and maintaining mitochondrial homeostasis [0.03%]
磷酸二酯酶5抑制剂LW1646通过缓解内质网应激和维持线粒体稳态改善肾脏纤维化
Minghui Wang,Meng Li,Xi Yuan et al.
Minghui Wang et al.
Renal fibrosis is the terminal pathological manifestation of most chronic kidney diseases. The phosphodiesterase type 5 (PDE5) inhibitors have shown therapeutic potentials in a wide array of chronic conditions. LW1646 is a newly identified ...
Mechanistic insights into selenium nanoparticles: Comparative effects in plant and animal systems [0.03%]
硒纳米粒子机制研究：植物和动物体系中的比较效应
Lulu Zhao,Yadi Xing,Maozhi Ren et al.
Lulu Zhao et al.
Selenium nanoparticles (SeNPs), characterized by high bioavailability and low toxicity, have emerged as a class of redox-active nanomaterials that can modulate cellular oxidative states. However, previous reviews have largely considered the...
The iron overload caused by non-enzymatically glycated transferrin triggers oxidative stress and ferroptosis by regulating the PI3/AKT signalling pathway and the expression of Nrf2 to promote renal damage in diabetes [0.03%]
糖尿病非酶促糖基化转铁蛋白所致铁过载通过调节PI3 / AKT信号通路及Nrf2的表达促进肾损伤、氧化应激及铁死亡形成
Pingping Zhao,Binjing Pan,Xiaoyu Lv et al.
Pingping Zhao et al.
Non-enzymatic glycation is an important post-translational modification of proteins, ultimately forming advanced glycation end products (AGEs). In a high-glucose environment, the glycation degree of transferrin (Tf) increases, leading to el...
Corrigendum to "O-GlcNAc transferase orchestrates oocyte maturation by modulating the activity of mitochondrial respiratory chain complex I" [Free Radic. Biol. Med. 248 (2026) 194-209, FRB 17667] [0.03%]
“O-GlcNAc转移酶通过调节线粒体呼吸链复合物I的活性来协调卵母细胞成熟”[Free Radic. Biol. Med. 248 (2026) 194-209，FRB 17667]的勘误表
Zhiming Ding,Caiyun Wu,Xuanxi Li et al.
Zhiming Ding et al.
Published Erratum
Free radical biology & medicine. 2026 Nov:255:987. DOI:10.1016/j.freeradbiomed.2026.08.031 2026
A dual-function guanidinium scaffold for copper sequestration and redox protection in Wilson disease models [0.03%]
一种用于威尔森病模型中铜螯合和氧化还原保护的双功能胍支架
Raviranjan Pandey,Arpan N Roy,Sandip Sarkar et al.
Raviranjan Pandey et al.
Wilson disease (WD) is caused due to mutations in the copper ATPase gene ATP7B, resulting in accumulation of copper and the consequent disruption of cellular redox balance through reactive oxygen species generation. Current therapies mainly...