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Integration of EMAP-II-targeted anti-angiogenesis and photodynamic therapy using zinc phthalocyanine nanosystem for enhanced cancer treatment [0.03%] 基于锌酞菁纳米系统的EMAP-II靶向抗血管生成与光动力学治疗联合增强癌症治疗效应
Liyun Chen,Linlin Li,Hailong Zhao et al. Liyun Chen et al.
Angiogenesis provides essential nutrients and oxygen to tumors during tumorigenesis, facilitating invasion and metastasis. Consequently, inhibiting tumor angiogenesis is an established strategy in anti-cancer therapy. In this study, we engi...
A multifunctional graphene oxide-based nanodrug delivery system for tumor targeted diagnosis and treatment under chemotherapy-photothermal-photodynamic synergy [0.03%] 基于氧化石墨烯的多功能纳米药物输送系统协同化疗-光热-光动力实现肿瘤精准诊疗
Huirui Zhu,Ruolan Feng,Dongkun Li et al. Huirui Zhu et al.
Traditional cancer therapies, such as chemotherapy, often lack specificity, resulting in severe toxic side effects and limited therapeutic efficacy. There is an urgent need to develop innovative multifunctional nanomedicine carriers that in...
Tumor-targeted nanosystem with hypoxia inducible factor 1α inhibition for synergistic chemo-photodynamic therapy against hypoxic tumor [0.03%] 一种针对肿瘤的纳米系统通过抑制缺氧诱导因子1α对低氧肿瘤进行协同化疗和光动力治疗
Ruifeng Zeng,Rui Zhou,Lu Zhen et al. Ruifeng Zeng et al.
Photodynamic therapy (PDT) holds an essential role in the therapy of tumors. However, PDT consumes tissue oxygen and diminishes its own efficacy by inducing tumor hypoxia through the HIF-1α/VEGF pathway. Therefore, overcoming the photodyna...
Juxtaposing the antibacterial activities of different ZIFs in photodynamic therapy and their oxidative stress approach [0.03%] 不同MOF在光动力治疗中的抗菌活性及氧化应力途径的比较研究
Ruth Antwi-Baah,Mirabel Ewura Esi Acquah,Malcom Frimpong Dapaah et al. Ruth Antwi-Baah et al.
Instigating oxidative stress is a crucial aspect of antibacterial therapy. Yet, its behavior is poorly understood in the context of zeolitic imidazolate frameworks (ZIFs) - a group of highly promising antibacterial agents. To address this g...
Manganese-doped carbon dots with catalase-like activity enable MRI-guided enhanced photodynamic therapy [0.03%] 锰掺杂的类过氧化氢酶活性碳点用于磁共振引导的光动力治疗
Huihui Wang,Dongchuan Chu,Maolin Zhang et al. Huihui Wang et al.
The tumor microenvironment (TME) exhibits characteristics such as hypoxia, weak acidity, and enrichment of glutathione and hydrogen peroxide (H2O2), which greatly limits the effectiveness of tumor magnetic resonance imaging (MRI) and photod...
Facultative probiotics enable improved tumor distribution and deep penetration of photosensitizer for enhanced photodynamic therapy [0.03%] facultative probiotics能改善肿瘤部位的光敏剂分布并实现其深穿透以增强光动力学疗法疗效
Yuxin Guo,Peipei Wan,Yue Xu et al. Yuxin Guo et al.
Photodynamic therapy (PDT) is an emerging cancer therapy known for its non-invasive approach and minimal side effects. However, the clinical effectiveness of PDT is limited by the poor distribution and penetration of photosensitizers (PS) i...
Reusable and non-invasive TiO2-based photodynamic transdermal patch (RPT) for treating MDR-negative bacteria strain and promote wound healing through a synergistic approach of ROS-induced RNS [0.03%] 一种可重复使用的非侵入性TiO2基光动力透皮贴片(RPT)，通过ROS诱导的RNS协同作用治疗MDR阴性菌株并促进伤口愈合
Thala K,Aditi Machina,Shagufta Parveen et al. Thala K et al.
Wound healing is delayed due to the infection and biofilm formation of antibiotic-resistant species of gram-negative bacteria especially Pseudomonas aeruginosa and Escherichia coli. Antibacterial photodynamic therapy provides an efficient t...
Jiacheng Zhou,Mingmei Ji,Yuwei Yang et al. Jiacheng Zhou et al.
Two-photon photodynamic therapy (TP-PDT) offers an innovative approach to cancer treatment that utilizes near-infrared light to activate photosensitizers and generate reactive oxygen species (ROS) for targeted cancer cell elimination. TiO2-...
One-pot synthesis and covalent conjugation of methylene blue in mesoporous silica nanoparticles - A platform for enhanced photodynamic therapy [0.03%] 介孔硅纳米颗粒中亚甲基蓝的单锅合成和共价连接-一种增强光动力疗法的平台
Haritha Kirla,Jiansha Wu,Juliana Hamzah et al. Haritha Kirla et al.
Photodynamic therapy (PDT) is an emerging clinical modality for diverse disease conditions, including cancer. This technique involves, the generation of cytotoxic reactive oxygen species by a photosensitizer in the presence of light and oxy...
Photodynamic therapy based on bismuth oxyiodide nanoparticles for nondestructive tooth whitening [0.03%] 一种基于碘氧化铋纳米粒子的光动力牙齿美白方法
Ge Pan,Haoyu Wang,Zongjia Li et al. Ge Pan et al.
Achieving a desired whitening effect through short treatments without using peroxide and without compromising the integrity of tooth enamel remains a challenge in teeth whitening. Here, we developed a highly safe and efficient photodynamic ...