Synergistic Approaches in Moxifloxacin Detection: Modified Electrodes and Molecular Modeling Perspectives. A Review [0.03%]
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Hajar Oumoussa,Youssra El Hamdouni,Mohamed Bendany et al.
Hajar Oumoussa et al.
Moxifloxacin (MOX), an antibiotic used in the treatment of bacterial infections, is generating growing interest in health and environmental monitoring. Electroanalytical techniques like Electrochemical Impedance Spectroscopy (EIS), Cyclic V...
An Expedition of FDA-Approved Anticancer Drugs in 2024: Synthetic Routes, Mechanisms of Action, and Clinical Indications [0.03%]
2024年FDA批准的抗癌药物探索：合成路线、作用机制及临床适应症分析
Md Mustahidul Islam,Issac V Cherian,Shivani Kasana et al.
Md Mustahidul Islam et al.
The year 2024 witnessed significant advancements in cancer therapy, with the U.S. Food and Drug Administration (FDA) approving 56 anticancer drugs for various malignancies. These approvals encompass 36 organic small molecules and 20 macromo...
Privileged Scaffolds In Drug Discovery And Medicinal Chemistry [0.03%]
药物发现和药化中的privileged scaffolds
Guang Huang,Wen Zhou,Raj Kumar
Guang Huang
Recent Advances and Future Directions in 5-Fluorouracil Drug Delivery: A Comprehensive Review [0.03%]
5-氟尿嘧啶给药的近期进展和未来方向——全面综述
Ruobei Shu,Wuhao Wei,Zhaokai Li et al.
Ruobei Shu et al.
Given the multiple challenges associated with the clinical use of 5-fluorouracil (5-FU), including pronounced fluctuations in plasma concentrations, significant interindividual metabolic variability, and frequent systemic adverse reactions,...
Wnt Signaling in Tumorigenesis: From Molecular Mechanisms to Precision Therapeutic Targets [0.03%]
Wnt信号通路与肿瘤发生发展：从分子机制到精准治疗靶点
Guizhen Lyu,Yuxin Zhang,Dongbing Li
Guizhen Lyu
The Wingless/Integrated (Wnt) signaling pathway governs embryogenesis, stem-cell renewal, and tissue repair; its dysregulation is a pivotal oncogenic driver. This review integrates recent multi-omic and translational studies to delineate ho...
A Systematic Review on Exploration of Extracts and Phytochemicals for Peptic Ulcer from 2018 to 2024 [0.03%]
2018至2024年番石榴叶提取物和植物化学物质治疗消化性溃疡的系统评价
Zulfa Nooreen,Ankita Wal,Vinayak Rai et al.
Zulfa Nooreen et al.
Introduction: Worldwide, peptic ulcer disease affects a large number of individuals. In order to treat this condition, new, safe, and efficient treatments must be created because of the growing resistance to many traditio...
Antibody Therapies Targeting Amyloid-β and Tau in Alzheimer's Disease with Insights on Mechanisms, Clinical Trials, and Challenges [0.03%]
针对阿尔茨海默病中淀粉样蛋白和Tau的抗体治疗机制、临床试验及挑战的见解
Astik Manju Ashesh,Sanjana Gupta,Talha Jawaid et al.
Astik Manju Ashesh et al.
Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) deposits and neurofibrillary tangles containing phosphorylated tau protein. Around 57 million people worldwide were estimated by the World Health Organization to have dementia in...
Significance of Paraptosis in Cancer Treatment and its Induction by Natural Molecules [0.03%]
天然分子诱导的癌细胞抛帕托西在癌症治疗中的意义研究
Shivam Rajput,Rishabha Malviya,Sathvik Belagodu Sridhar et al.
Shivam Rajput et al.
All organisms rely on Programmed Cell Death (PCD) to keep their cells in a constant state of homeostasis and to control their development, health, and illness. PCD is classified by its mechanisms, such as autophagy, apoptosis, paraptosis, a...
Therapies Applied to Biological Barriers: From Overcoming to Tissue Regeneration [0.03%]
应用于生物屏障的治疗：从克服到组织再生
Daniele Ribeiro de Araujo,Wendel Andrade Alves,Vinicius Andrade-Oliveira
Daniele Ribeiro de Araujo
Navigating through Neuropathic Pain: From Pathophysiology to Present and Future Treatments [0.03%]
从神经病理性疼痛的病理生理学到当前和未来的治疗方案
Sanchita Aggarwal,Ravi Pratap Barnwal,Gurpal Singh et al.
Sanchita Aggarwal et al.
Neuropathic pain (NP) results from lesions or malfunctions in the somatosensory nervous system. Neuropathic pain is a multifaceted health condition that currently lacks a universally accepted classification system or definitive biomarkers f...