Bioisosteric Replacement of Carboxylic Acids in PPAR Agonists: A Mini Review [0.03%]
PPAR受体激动剂中羧酸的生物等排替换研究进展小结
Adriana Coricello,Alessio De Simone,Giovanni Bottegoni
Adriana Coricello
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate metabolic homeostasis and represent important therapeutic targets for conditions such as type 2 diabetes, dyslipidemia, and cardiovascular disease. Whil...
EBF1: A Multidimensional Role Integrating Metabolism and Metabolic Diseases [0.03%]
EBF1：一个连接代谢与代谢性疾病的多维度角色
Yining Pan,Haoran Liu,Jiayi Ma et al.
Yining Pan et al.
Introduction: Early B-cell factor 1 (EBF1) is a multifunctional transcription factor. It plays a pivotal role in regulating biological processes such as B-lymphocyte development and neuronal differentiation. EBF1 has been...
Glycogen Synthase Kinase-3β in Alzheimer's Disease: Targets for Therapy and Imaging [0.03%]
甘特明 kinase-3β在阿尔茨海默病中的治疗和影像靶点研究
Jianhua Jia
Jianhua Jia
Glycogen synthase kinase-3β (GSK-3β) is a key regulator of the pathogenesis of Alzheimer's disease (AD), capable of simultaneously modulating core pathological processes such as amyloid-β (Aβ) deposition, tau protein hyperphosphorylatio...
Antiproliferative Activity, DNA/HSA Interactions and Human Topoisomerase Inhibition Evaluations of Indole-Thiazolidinone Derivatives: Are Two Indole Rings Better than One? [0.03%]
吲哚-噻唑啶衍生物的抗增殖活性、DNA/人血清白蛋白相互作用及人拓扑异构酶抑制作用评估：两个吲哚环比一个更好吗？
Maksuelly Libanio de Lima,Rafael David Souto de Azevedo,Fernanda Carvalho Manito Ferreira et al.
Maksuelly Libanio de Lima et al.
Introduction: Indole derivatives are promising candidates for anticancer drug discovery due to their occurrence in biologically active molecules and their ability to modulate cellular targets. This study aimed to evaluate...
Biotransformation-Driven Structural Remodeling of Natural Products by Ganoderma lucidum Fermentation: Mechanisms and Enhanced Bioactivities [0.03%]
灵芝发酵来源天然产物的生物转化结构重塑机制及其活性增强效应研究
Yuchen Liu,Bing Liu,Ting Zhu et al.
Yuchen Liu et al.
Ganoderma lucidum fermentation (GLF) serves as a sustainable biotransformation platform that precisely modulates the chemical profiles and bioactivities of natural products through enzymatic hydrolysis, microbial metabolic remodeling, and s...
Advances in Heterocyclic Derivatives for Aromatase Inhibition in Hormone-Dependent Breast Cancer [0.03%]
激素依赖性乳腺癌芳香化酶抑制的杂环衍生物研究进展
Harsimran Kaur,Kawalpreet Kaur,Gurdeep Singh
Harsimran Kaur
Breast cancer is one of the most common causes of cancer death among women in the world, and the number of tumors that depend on hormones occupies a significant percentage of cases that are diagnosed. The estrogen factor is central to the d...
Corrigendum to: Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring [0.03%]
关于抗体-适配体互补：推进疾病监测的生物传感技术的更正
Thangavel Lakshmipriya,Subash C B Gopinath
Thangavel Lakshmipriya
In the originally published article entitled "Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring", published in "Current Topics in Medicinal Chemistry" Vol: 26 Issue: 03 [1], a duplication inadvertently appeared i...
Disrupting Bacterial Quorum Sensing: A Review of Protein Families and Natural Inhibitors for Combating Resistance [0.03%]
扰乱细菌群体感应：抗药性作战的蛋白家族和天然抑制剂综述
Asghar Ali,Andaleeb Zahra,Mohan Kamthan et al.
Asghar Ali et al.
The Quorum Sensing (QS) system plays a central role in regulating several processes that influence bacterial physiology, communication, and pathogenesis. It governs the production of virulence factors, facilitates biofilm formation, and con...
Research Progress on the Role of AMPK Signaling Pathway in the Regulation of Neural Injury [0.03%]
AMPK信号通路在神经损伤调控中的作用研究进展
JiaTai An,XiuHua Li,TangNa Zhao et al.
JiaTai An et al.
Introduction: Nerve Injury (NI) imposes a severe clinical burden involving energy failure, neuroinflammation, oxidative stress, and apoptosis. This review aims to systematically synthesize structural insights into AMP-act...
Antidiabetic Potential of Garcinia atroviridis Griff: In Vitro and In Vivo Evaluation of Glucose Metabolism and Enzyme Inhibition [0.03%]
Garcinia atroviridis Griff抗糖尿病潜力的体内外评价：葡萄糖代谢和酶抑制作用
Ibrahim Mahmood,Song Zhu,Douglas Law et al.
Ibrahim Mahmood et al.
Diabetes mellitus (DM) is characterized by hyperglycemia, insulin resistance, and pancreatic β-cell failure, necessitating novel treatments. Garcinia atroviridis, rich in hydroxy citric acid (HCA), flavonoids, and polyphenols, shows potent...