A heparan sulfate-mimetic derivative of botryosphaeran with antiviral activity against herpes simplex virus [0.03%]
一种抗单纯疱疹病毒活性的botryosphaeran的硫酸肝素类似物衍生物
Flávia Deduch Kikuchi,Mario Gabriel Lopes Barboza,André Luiz Dyna et al.
Flávia Deduch Kikuchi et al.
Herpes is a viral disease with high worldwide prevalence. The lack of herpes vaccines and the growing viral resistance to acyclovir and its analogues create an urgent need for new treatment strategies. Anionic polysaccharides, especially su...
Design, synthesis, in vitro anticancer evaluation, in silico molecular docking and ADMET profiling of carbohydrate-conjugated pyridine oximes [0.03%]
含吡啶肟类糖基衍生物的设计合成及体外抗肿瘤活性评价、分子对接与药代动力学性质研究
Mohammed Ansar Ahemad,Bhabani Shankar Panda,Sabita Nayak et al.
Mohammed Ansar Ahemad et al.
Herein, some new carbohydrate-conjugated pyridine oximes were designed, synthesized, and evaluated as promising anticancer agents. The synthesized compounds were characterized using 1H NMR, 13C NMR, and HRMS spectroscopy. The in vitro antic...
The effect of trifluoroacetic acid on the endocyclic cleavage of ethyl 1-thio-β-d-manno-, gluco-, galacto- and β-l-fucopyranosides with bulky silyl groups [0.03%]
trifluoroacetic酸对乙基1-硫-D-吡喃型甘露糖苷，葡萄糖苷，半乳糖苷和L-岩藻糖苷内环开裂的影响
Polina I Abronina,Alexander I Zinin,Nelly N Malysheva et al.
Polina I Abronina et al.
Earlier we found that the treatment of ethyl 1-thio-β-d-galactopyranoside containing triisopropylsilyl (TIPS) groups at O-2 and O-3 with TFA-CH2Cl2 led to the corresponding 2,3-bis-O-silylated 1-thio-d-galactofuranoside. However, when ethy...
Enzymatic degradation of Hyaluronic acid/Poly-l-Lysine capsules for burst drug release [0.03%]
透明质酸/聚lysine胶囊的酶降解控制药物突释现象
Luis A Martins,Edward Suesca,María Inmaculada García-Briega et al.
Luis A Martins et al.
The aim of this study is to investigate the process by which multilayer polyelectrolyte microcapsules rupture under the action of enzymes to which the polyanion or polycation is sensitive. The capsules were prepared using a template of algi...
Pine oleoresin and methyl cellulose-incorporated adaptive hydrogels with self-healing capability, suppressed swelling, and enhanced thermal performance [0.03%]
具有自愈能力、抑制溶胀和增强热性能的松香树脂和甲基纤维素改性自适应水凝胶
Naile Angın
Naile Angın
Physically crosslinked hydrogels are promising soft materials nevertheless, excessive swelling resulting from their hydrophilic nature remains a major limitation that can adversely affect their dimensional stability and long-term performanc...
Comparative kinetic evaluation of native and gelatinised starch hydrolysis by α-amylases [0.03%]
淀粉酶水解天然和明胶化淀粉的比较动力学评估
Lisa Coddens,Charlotte F De Schepper,Kristof Brijs et al.
Lisa Coddens et al.
Native starch-degrading α-amylases offer opportunities for more sustainable starch-processing strategies. While individual native starch-degrading α-amylases have been studied, systematic quantitative and comparative analyses are scarce a...
Multidomain annotation of carbohydrate-active enzymes beyond CAZy domains with GeneHunt2 [0.03%]
GeneHunt2：CAZy 域以外的碳水化合物活性酶多域注释
Renaud Berlemont
Renaud Berlemont
Carbohydrate-active enzymes (CAZymes) are central to carbohydrate metabolism, yet their functional annotation is typically restricted to catalytic CAZy domains, overlooking the broader multidomain architectures in which these domains operat...
Wesley J Moran
Wesley J Moran
The investigation of a halogen-bonding (XB) approach to the glycosylation of glycals using an iodolium salt is presented. This approach utilizes an air and moisture stable XB catalyst and readily generates a range of glycosides under mild c...
Discovery and characterization of a novel GH6 multifunctional enzyme from soil metagenomic library [0.03%]
从土壤元基因组文库中发现并鉴定出一种新的GH6多功能酶
Yunbin Lyu,Shenghong Wu,Xinyu Fan et al.
Yunbin Lyu et al.
Cellulases are crucial for converting biomass into renewable energy. Despite extensive research, there remains a significant industrial demand for novel cellulases, particularly those with multi-substrates catalytic activity. This study aim...
Efficient one-step transformation of chitin to organonitrogen platform compound 3-acetamido-5-acetylfuran with a facile and low-cost ternary composite catalyst [0.03%]
一种用于一步转化几丁质制备含氮有机平台化合物3-乙酰氨基-5-乙酰基呋喃的简易低成本三元复合催化剂
Changchun Wu,Qian Yang,Antong Li et al.
Changchun Wu et al.
Chitin, an abundant marine biomass resource, holds great potential for the sustainable preparation of high-valued nitrogen-containing chemicals to reduce the environmental footprint associated with the Haber-Bosch process. However, current ...