Synthesis and in vitro studies of doxorubicin-Cu2+ prodrug and glucose oxidase co-encapsulated oxidized hyaluronic acid/carboxymethyl chitosan hydrogels on breast cancer cell line 4T1 [0.03%]
负载多西他星-铜(Ⅱ)前药及葡萄糖氧化酶的透明质酸钠/羧甲基壳聚糖交联水凝胶的制备及其对乳腺癌细胞系4T1的体外研究
Shuhan Li,Huwei Bian,Yuting Tan et al.
Shuhan Li et al.
Breast cancer is one of the most life-threatening malignancies worldwide, and the chemotherapy of breast cancer is often hindered by drug resistance and systemic toxicity. Developing safer and more efficient multi-therapy strategies is ther...
Structure and gene cluster of the capsular polysaccharide produced by Acinetobacter baumannii K111 [0.03%]
产粘质沙雷氏菌K111的荚膜多糖结构与基因簇
Andrei V Filatov,Anna M Shpirt,Andrei V Perepelov et al.
Andrei V Filatov et al.
Structure of the capsular polysaccharide (CPS) from A. baumannii MAR21-2688 strain (classified as KL111 type) was established using 1H and 13C NMR spectroscopy, including two-dimensional homonuclear 1Н,1Н COSY, TOCSY, ROESY and heteronucl...
Structural diversity of the OPSs isolated from the LPSs of the plant pathogenic bacteria Pectobacterium parmentieri IFB5441 and IFB5533 [0.03%]
来自植物病原菌Pectobacterium parmentieri IFB5441和IFB5533的LPS中分离到的OPS结构多样性研究
Karolina Ossowska,Natalia Kaczyńska,Agnieszka Kowalczyk et al.
Karolina Ossowska et al.
Pectobacterium parmentieri is a pectinolytic pathogenic bacterium causing high economic losses in plant crops. Lipopolysaccharide is one of the bacterial virulence factors that play an important role in plant colonisation and interaction wi...
Unexpected formation of furanose form during deacetylation of pyranose glyco-oxazolines [0.03%]
脱乙酰基过程中吡喃糖甘氧唑啉意外形成呋喃糖异构体
Maxim A Romanyuk,Ilya V Myachin,Maria V Panova et al.
Maxim A Romanyuk et al.
We have found that the deacetylation of O-acetylated pyranose glyco-oxazoline, derived from N-acetyl-d-glucosamine, using MeONa or other bases (Et3N, K2CO3) in MeOH, selectively gives the expected pyranose triol at 20 °C. In contrast, at 6...
Yam polysaccharide extraction, purification, structural features, and biological properties: A review [0.03%]
甘薯多糖的提取、纯化、结构特征及生物学性能研究进展综述
Chongbi Wei,Shaowa Lv,Lei Jiang et al.
Chongbi Wei et al.
Yam (Dioscorea opposita Thunb.) is a widely used culinary and medicinal plant rhizome with a long application history. The polysaccharides in yam are important bioactive components. As a natural polysaccharide, yam polysaccharides exhibit s...
Jacob A Clark,Agata Zykwinska,Sylvia Colliec-Jouault et al.
Jacob A Clark et al.
Sulfated glycosaminoglycans (GAGs) are a large family of linear and highly negatively charged polysaccharides with many roles in tissue structure and physiology. Interest in glycosaminoglycans and molecules with mimetic properties has led t...
Recent advances in glyco-nanoparticles for probing the glyco-codes of cancer [0.03%]
用于探测癌症糖编码的糖基纳米颗粒最新研究进展
A K M Atique Ullah,Xuefei Huang
A K M Atique Ullah
Aberrant glycosylation is a hallmark of cancer, producing tumor-associated carbohydrate antigens (TACAs) and altering cell-surface interactions that reshape adhesion, signaling, and immune recognition. These altered glycans, collectively re...
Parameter optimisation of a microreactor based continuous synthesis of bromooctyl glucoside by Fischer glycosylation [0.03%]
基于Fischer糖基化的溴辛基葡萄糖苷连续合成的微通道反应器参数优化
Jessica Jung-Fittkau,Jascha Schmeh,Angelika Czajkowska et al.
Jessica Jung-Fittkau et al.
Bromalkyl glycosides are promising molecules for use as functionalised spacers in the production of glycomimetics. The here presented optimised process can serve as the basis for the technical synthesis of bromoalkyl glycosides in a microre...
Structure and gene cluster of the capsular polysaccharide of Acinetobacter baumannii K104 [0.03%]
阿氏伯克曼菌K104型荚膜多糖结构及基因簇分析
Anna M Shpirt,Zakhar V Serpokrylov,Andrei V Perepelov et al.
Anna M Shpirt et al.
Structure of the Acinetobacter baumannii MAR20-4513 (K104) capsular polysaccharide (CPS) was established using Smith degradation, 1H and 13C NMR spectroscopy, including two-dimensional homonuclear 1Н,1Н COSY, TOCSY, ROESY and heteronuclea...
Impact of 6-purine modifications on the ribose substrate selectivity of pyrimidine nucleoside phosphorylase (PyNP) in base exchange reactions [0.03%]
嘌呤修饰对嘧啶核苷磷酸化酶在碱基交换反应中核糖底物选择性影响的研究
Akihiko Hatano,Riki Matsuzaka,Rai Hamano et al.
Akihiko Hatano et al.
Pyrimidine nucleoside phosphorylase (PyNP) catalyzes phosphorolysis and base exchange reactions, providing an eco-friendly and stereoselective approach for synthesizing unnatural nucleosides. This study investigates PyNP substrate specifici...