Microbial fuel cell (MFC)-based biosensor for real-time detection of heavy metals and BTEX contaminants in water [0.03%]
基于微生物燃料电池(MFC)的实时检测水中重金属和BTEX污染物的生物传感器
Jong-Hyun Baik,Jae-Hoon Hwang,Hodon Ryu et al.
Jong-Hyun Baik et al.
This study evaluates a mixed-culture microbial fuel cell (MFC) as a rapid, real-time biosensor for detecting water toxicity caused by heavy metals and benzene, toluene, ethylbenzene, and xylene (BTEX) compounds. A dual-chamber MFC (200 mL) ...
Hierarchical nanoplatform for integrated detection and degradation of chloramphenicol:surface enrichment, confined enhancement and phosphate complexation [0.03%]
氯霉素集成检测和降解的分层纳米平台：表面富集、限制增强和磷酸盐配位
Yishuang Li,Zhixiong Pi,Xingyu Liu et al.
Yishuang Li et al.
The development of bifunctional platform capable of integrated recognition and elimination of trace contaminant residues remains a key challenge for water environmental monitoring. This work, the zirconium-based metal-organic frameworks (Zr...
Stepwise engineering of AmpR-based whole-cell biosensors for broad-spectrum detection and high-throughput screening of β-lactam compounds [0.03%]
基于AmpR的工程全细胞生物传感器的逐步开发用于广谱β-内酰胺类化合物检测及高通量筛选
Xueyan Liu,Baoyan Liu,Linlin Qi et al.
Xueyan Liu et al.
Cephalosporin C (CPC), a representative secondary metabolite of filamentous fungi, serves as the precursor for the industrial synthesis of 7-aminocephalosporanic acid (7-ACA), the key intermediate for semisynthetic cephalosporins. Metabolit...
Micrococcal Nuclease-Activated Theranostic Probe for Specific Imaging and Targeting Photothermal Eradication of Intracellular Staphylococcus aureus in Joints in vivo [0.03%]
一种用于体内活体关节内细胞胞内金黄色葡萄球菌特异性成像及靶向光热根除的核酸酶激活型诊疗一体化探针
Mingrong Wu,Fengqiong Gao,Yaqing Zhang et al.
Mingrong Wu et al.
The intracellular survival of Staphylococcus aureus (S. aureus) within immune cells poses a significant clinical challenge, driving recurrent infections and antibiotic resistance in orthopaedic practice. Specific identification and precise ...
Multiplexed nanophotonic sensor arrays for time-resolved biomolecular analysis [0.03%]
用于生物分子时间分辨分析的复用纳米光子传感器阵列
Lisa M Miller,Christopher P Reardon,Kathryn G Leslie et al.
Lisa M Miller et al.
Complex diseases arise from networks of interacting biomolecules, yet most analytical technologies measure only a limited number of interactions simultaneously. Here, we present a chirped guided-mode resonance (cGMR) photonic biosensor arra...
Portable amplification-free digital droplet CRISPR/Cas12a platform for one-pot multiplexed viruses detection with attomolar sensitivity [0.03%]
一种便携式的扩增免CRISPR/Cas12a数字微滴平台，可在一次性多重反应中实现阿摩尔级灵敏度的病毒检测
Zhirun Ji,Yiran Zhao,Juncan Huang et al.
Zhirun Ji et al.
High-throughput, sensitive, and field-deployable nucleic acid detection is essential for timely pathogen surveillance. Here, we developed a novel amplification-free and portable platform based on an instrument-free polydisperse digital drop...
Two-enzyme encapsulated nano metal organic framework hybrid probe based phage sensor for bioluminescent and electrochemical dual-mode detection of pathogenic bacteria bioactivity [0.03%]
基于噬菌体传感器的双酶封装纳米金属有机框架杂化探针用于病原菌生物发光和电化学双模式检测
Zhihao Tao,Renjie Zhou,Shu Xiao et al.
Zhihao Tao et al.
The assessment of both live and dead bacteria is critically essential for evaluating the infectivity and potential hazards of pathogenic microorganisms. In this study, the luciferase and lysozyme were initially encapsulated within a ZIF-8 M...
Ultrasensitive electrochemical detection of clinically relevant genetic mutations via nanoparticle surface localized amplification and machine learning [0.03%]
基于纳米粒子表面局部放大和机器学习的临床相关遗传突变的超灵敏电化学检测
Sun Yeoung Na,Hong En Fu,Yo Seop Shin et al.
Sun Yeoung Na et al.
Genetic mutation detection is crucial for early disease diagnosis, prognosis assessment, and the implementation of precision medicine, as it enables the identification of key biomarkers that directly influence treatment decisions and patien...
A scalable, enzyme-free, multimodal wearable monitoring system with active-flux-regulated sweat extraction for on-demand metabolic assessment [0.03%]
一种可扩展、无酶、多模态的可穿戴监测系统，具有主动通量调节出汗提取功能，适用于按需代谢评估
Zhifu Yin,Yachuan Qu,Yang Yang et al.
Zhifu Yin et al.
Real-time, non-invasive biofluid monitoring is pivotal for precision medicine. However, conventional wearable sensing systems are constrained by their reliance on passive sampling, as well as barriers to design and fabrication. Integrating ...
An ACRCA-microchip integrated with immune-reaction and RCA for trace norovirus antigen detection [0.03%]
一种集成了免疫反应和滚环放大技术的ACRCA微芯片用于超灵敏诺如病毒抗原检测
Pengda Wei,Yang Sun,Fucheng Wang et al.
Pengda Wei et al.
Protein detection plays a crucial role in early disease diagnosis and therapeutic efficacy assessment. However, it has consistently faced the challenge of single-molecule level sensitivity, lacking signal amplification capability like nucle...