Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold [0.03%]
Yongan Ren,Wangchao Du
Yongan Ren
Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation hetero...
Elucidating the nanointerface-enabled enzymatic cascade amplification mechanism for a precise self-powered strategy [0.03%]
Qingnian Wu,Chenchen Jin,Tao Wen et al.
Qingnian Wu et al.
This study pioneers a enzymatic biofuel cell that fundamentally redefines portable detection of sugarcane pokkah boeng disease through synergistic nanomaterial engineering and molecular circuitry design. As a single-enzyme architecture, Exo...
Living electronics: Coupling S. oneidensis MtrC-SpyTag cells to SpyCatcher-functionalized electrodes for direct electron transfer [0.03%]
Lukas Kneuer,René Wurst,Christian Jonas Lapp et al.
Lukas Kneuer et al.
This work set out to establish an easily applicable system to improve a broad range of bioelectronic devices using the SpyTag-SpyCatcher crosslinking system together with one of the model organisms for extracellular electron transport, Shew...
Heterolinker MOFs synergized with entropy-driven DNA amplification for precision dual-mode sensing of Microcystin-LR [0.03%]
Yawei Sun,Yamei Li,Zhuangzhuang Ru et al.
Yawei Sun et al.
To overcome the high risk of false results in single-mode detection for environmental toxins, a self-validating dual-mode biosensing platform integrating photoelectrochemical (PEC) and fluorescence (FL) signals was developed for the ultrase...
Multi-hotspot coupled metasurface for fingerprint identification of trace carcinoembryonic antigen molecules [0.03%]
Xiaoxuan Li,Linlong Tang,Xiaojian Zhang et al.
Xiaoxuan Li et al.
Cancer remains a major global health challenge, highlighting the need for effective biomarker monitoring. Carcinoembryonic antigen (CEA), a widely used tumor-associated marker, is crucial for cancer diagnosis. Surface-enhanced infrared abso...
Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection [0.03%]
Xiaofei Sun,Lei Qian,Di Jin et al.
Xiaofei Sun et al.
Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrate...
Haoyu Wang,Dong Zhao,Sitong Wu et al.
Haoyu Wang et al.
Surface stress, as an indicator of cellular state, responds to morphological changes, signaling, and disease processes, and is therefore highly significant for early diagnosis and precise disease monitoring. However, cell surface stress can...
Covalently functionalized MoS2 nanopore with amino acids for label-free protein residue discrimination [0.03%]
Junzhou He,Yubin Cao,Meiting Zeng et al.
Junzhou He et al.
Precise detection of amino acids is critical for proteomics and molecular recognition. Nanopore sensing enables label-free single-molecule analysis but often lacks sufficient spatial resolution to control translocation dynamics and resolve ...
Mengdan Lu,Ji Qi,Younju Joung et al.
Mengdan Lu et al.
This study presents an electrophoresis-assisted surface-enhanced Raman scattering (SERS)-based lateral flow assay (E-SERS-LFA) for the simultaneous detection of human immunodeficiency virus p24 antigen (HIV p24) and hepatitis B virus surfac...
Accurate diagnosis of triple-negative breast cancer enables temperature-compensation all optical microfibre gratings system [0.03%]
Xin Liu,Qiao Xu,Yunlong Wang et al.
Xin Liu et al.
Accurate clinical diagnosis of triple-negative breast cancer (TNBC) usually needed tedious, time consuming, high-cost tissue section analyzation procedures by using conventional clinical medical approaches. Thus, it is an urgent to develop ...