Degree-based topological indices, NMR chemical shifts, chemical reactivity, molecular dynamics and DFT analysis of 1,4-Methanoazulene-9-methanol, Decahydro-4,8,8-trimethyl-, [1S-(1α,3aβ,4α,8aβ,9R)] [0.03%]
基于度的拓扑指标，核磁共振化学位移，化学反应性，分子动力学和DFT分析1,4-甲基偶氮烯-9-醇，十氢-4,8,8-三甲基-[1S-(1α,3aβ,4α,8aβ,9R)]
Jeffrin Ja Laura,P Rajesh,M Kesavan et al.
Jeffrin Ja Laura et al.
This study aims to comprehensively analyze the structural, vibrational, and electrical characteristics of 11,4-Methanoazulene-9-methanol, decahydro-4,8,8-trimethyl-, [1S-(1α,3aβ,4α,8aβ,9R*)] (MMDT) with a focus on its potential as a the...
Phenolic fractions of Heliotropium Bacciferum inhibit human insulin aggregation and protect against amyloid-induced cytotoxicity: Structural and biophysical analysis [0.03%]
采用结构和生物物理方法分析盾翅夏至草中酚类组分可抑制人胰岛素聚集并保护细胞免受淀粉样蛋白诱导的细胞毒性作用
Moneera Saud Al-Bagmi,Majed S Alokail,Nasser M Al-Daghri et al.
Moneera Saud Al-Bagmi et al.
In humans, more than 50 diseases are related to protein fibrillation, including Alzheimer's and Parkinson's diseases. Inhibition of amyloid fibril formation using natural products is one of the main therapeutic strategies for preventing the...
Receptor modulated assembly and drug induced disassembly of amyloid beta aggregates at asymmetric neuronal model biomembranes [0.03%]
受体调节的淀粉样蛋白β聚集物在不对称神经元模型生物膜上的组装及药物诱导的拆解
Nirod Kumar Sarangi,Subrata Mondal,Tia E Keyes
Nirod Kumar Sarangi
Amyloid peptide non-fibrillar oligomers cause neurotoxicity and may contribute to Alzheimer's disease (AD) pathogenesis. Mounting evidence indicates that Aβ1-42 oligomers disrupt and remodel neuronal membrane, causing neuronal cell death. ...
Interaction of Myrsinoic acid a with biomembrane models: Differential effects on DPPC and DPPS properties revealed by surface rheology and vibrational spectroscopy [0.03%]
髓醇酸A与生物膜模型的相互作用：表面流变学和振动光谱揭示其对DPPC和DPPS性质的不同影响
Ana Gabrieli A Dos Santos,Fernando Cassas,Kevin Figueiredo Dos Santos et al.
Ana Gabrieli A Dos Santos et al.
This study investigates the interactions of Myrsinoic acid A, a natural compound with reported anti-inflammatory and antitumor properties, with lipid monolayers composed of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylse...
The amyloidogenic peptide stretch in human tau, tau306-311 is a promising injectable hydrogelator [0.03%]
人tau蛋白中的淀粉样肽段tau306-311是一种有前景的可注射水凝胶材料
Shubhangini Singh Verma,Shinjini Bhattacharya,Sachin Kumar et al.
Shubhangini Singh Verma et al.
A vast majority of peptide hydrogelators harbor a bulky, non-native aromatic moiety. Such foreign moieties raise safety concerns as far as biomedical applications of hydrogels are concerned. The hydrogel research, therefore, has branched to...
A detailed review of genetically encodable RFPs and far-RFPs and their applications in advanced super-resolution imaging techniques [0.03%]
可用于高级超分辨率成像技术的基因编码的RFPs和远红RFPs的详细回顾及其应用
Jianshu Dong,Bilal Tayyab,Jiangyun Wang
Jianshu Dong
The red fluorescent proteins (RFPs) and far-red fluorescent proteins (far-RFPs) that are encoded genetically can emit fluorescence within the spectral ranges of 580-680 nm when exposed to the light of appropriate wavelengths. Unlike many RF...
Brigitte Magdalena Merino,Rosa Bartucci,Rita Guzzi
Brigitte Magdalena Merino
The study of protein-lipid interaction offers interesting insights into the mutual alterations determined in the formation of the supramolecular complex. It gains even more interest, not only in basic research but also in biomedical and bio...
Characterization of metabolism associated with outcomes in severe acute pancreatitis: Insights from serum metabolomic analysis [0.03%]
重症急性胰腺炎预后相关的代谢特征研究：血清代谢组学分析的启示
Mohd Adnan Siddiqui,Anamika Singh,Swarnima Pandey et al.
Mohd Adnan Siddiqui et al.
Severe Acute Pancreatitis (SAP) is characterized by an abrupt onset of pancreatic inflammation, which may induce damage to other organs, and is associated with significant morbidity and mortality. Despite the considerable disease burden, sp...
Decoding the interaction of an imidazo-pyrimidine derivative with serum proteins: Spectroscopic, computational and structure-activity relationship analysis [0.03%]
用于研究酰唑嘧啶衍生物与血清蛋白相互作用的谱学分析、计算分析和构效关系分析
Bishwayan Chakraborty,Asmit Santra,Debangana Tah et al.
Bishwayan Chakraborty et al.
In the present article, we have tried to theoretically analyze the structure-function relationship of a novel imidazo pyrimidine derivative, IPD, and decipher its interactions with two serum proteins, BSA and HSA, spectroscopically. IPD is ...
Autoencoder-based drug-virus association prediction with reliable negative sample selection: A case study with COVID-19 [0.03%]
基于自动编码器的药物病毒关联预测及可靠的负样本选择：以COVID-19为例
A S Aruna,K R Remesh Babu,K Deepthi
A S Aruna
Emergence of viruses cause unprecedented challenges and thus leading to wide-ranging consequences today. The world has faced massive disruptions like COVID-19 and continues to suffer in terms of public health and world economy. Fighting wit...