How glycosaminoglycans mediate procathepsin K maturation: New insights from computational studies [0.03%]
糖胺聚糖介导前 катhepsin K 成熟的机制：计算研究的新见解
Damian Suchomski,Patryk A Wesołowski,Krzysztof K Bojarski
Damian Suchomski
Cathepsins are predominantly cysteine proteases that function in lysosomes and the extracellular matrix, where they regulate essential proteolytic processes. They are synthesised as inactive zymogens (procathepsins), in which an N-terminal ...
Optimizing separation conditions for melittin purification from bee venom using molecular dynamics simulations [0.03%]
基于分子动力学模拟优化蜂毒中蜂毒肽的分离纯化条件
Azadeh Kordzadeh,Ahmad Ramazani Saadatabadi
Azadeh Kordzadeh
Melittin, an anticancer peptide, is the main component of bee venom. However, bee venom also contains phospholipase A2 and hyaluronidase-toxic enzymes that induce inflammatory responses. To facilitate therapeutic applications of melittin, t...
Carvacrol potentiates gentamicin against Staphylococcus aureus via disrupting bacterial respiratory bioenergetics [0.03%]
肉桂酸通过破坏细菌呼吸生物能量学来增强庆大霉素对金黄色葡萄球菌的疗效
Sijie Wu,Xiaomin Ren,Ronger Wu et al.
Sijie Wu et al.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) calls for novel antibiotic adjuvants. Carvacrol (Car), a natural monoterpene phenol derived from the essential oils of aromatic plants, exhibits membrane-active properties ...
Modulation of the phospholipid dynamics and bilayer water accessibility with the membrane-associated nucleation of β-amyloid (Aβ) peptides [0.03%]
β淀粉样蛋白（Aβ）肽与膜相关成核调节磷脂动力学和双层水可及性
Brian Lum,Wei Qiang
Brian Lum
Membrane disruption along the amyloidogenic aggregation of β-amyloid (Aβ) peptides is considered a molecular mechanism for the Aβ-induced cell toxicity and death. Yet, the underlying structural basis for the harmful Aβ-membrane interact...
Solid-state NMR methods to investigate biomolecular condensates, protein phase transition, phase separation and coacervates [0.03%]
固态核磁共振研究生物分子凝聚体、蛋白质相变、相分离和共聚集现象的方法学进展
Seamoon Deb,Erick J Dufourc,Birgit Habenstein et al.
Seamoon Deb et al.
The formation of biomolecular condensates has been linked to a broad range of essential cellular processes, including immune signaling cascades, mRNA transport, and autophagy. Conversely, phase-separated condensates have also been associate...
Advances in ratiometric fluorescent probes for quantitative imaging of endogenous hydrogen sulfide [0.03%]
比率型荧光探针在内源性氢硫化物定量成像中的研究进展
Vivek Pandey,Nikky Sharma,Tejasvi Pandey
Vivek Pandey
Hydrogen sulfide (H₂S) has emerged as a crucial endogenous gaseous signaling molecule involved in diverse physiological and pathological processes, including vascular regulation, neuronal transmission, inflammation, and cellular redox home...
Enhanced solid-state NMR sensitivity of α-synuclein fibrils using a MAS cryoprobe [0.03%]
利用MAS冷冻探针提高α-突触核蛋白原纤维固态NMR信号灵敏度
Malitha C Dickwella Widanage,Barbara Perrone,Jhinuk Saha et al.
Malitha C Dickwella Widanage et al.
Solid-state NMR spectroscopy is increasingly used to investigate the structure and dynamics of a wide range of chemical, material, and biological systems. Although limited sensitivity has long posed a major challenge, the recently developed...
Exploring the effect of carbon support dimensionality on FeN4-based acetone sensors [0.03%]
基于碳支持维度对FeN4基乙酸传感器的影响研究
Qamar Abuhassan,Kamel A Saleh,Narinderjit Singh Sawaran Singh et al.
Qamar Abuhassan et al.
This inclusive innovation study presents a computational investigation into the design of biosensors capable of detecting volatile organic compound (VOC) biomarkers. Density functional theory (DFT) calculations were employed to examine the ...
Hortense de La Seiglière,Ænora Letourneur,François Ichas et al.
Hortense de La Seiglière et al.
Neurodegenerative diseases such as Alzheimer's, Parkinson's, frontotemporal dementia, and ALS are characterized by amyloid protein aggregation involving intrinsically disordered proteins that are also capable of liquid-liquid phase separati...
NMR-based serum metabolomic signatures distinguish active tuberculosis from latent tuberculosis infection [0.03%]
基于核磁共振的血清代谢组标志物可区分活动性结核病和潜伏性结核感染
Sumit Kumar Jain,Alok Nath,Sachin Yadav et al.
Sumit Kumar Jain et al.
Background: Tuberculosis (TB) continues to be a major cause of global morbidity and mortality, particularly in low- and middle-income countries. A persistent challenge in TB control is the inability of current immunodiagn...