Gut microbiome-mediated modulation of the glioblastoma tumor microenvironment for enhanced immunotherapy response: Mechanistic insights and future perspectives [0.03%]
脑肠轴在胶质母细胞瘤免疫治疗中的机制作用及未来展望：聚焦肿瘤微环境重塑与内脏脂肪组织影响
Urjaswee Dey,Lakshmi Priya Madabhushi,Amisha Anna Chacko et al.
Urjaswee Dey et al.
Glioblastoma (GBM) is known to be one of the most aggressive and deadly brain tumors in adults, with a very poor prognosis. An immunosuppressive tumor microenvironment, the blood-brain barrier's (BBB's) protective nature, and genetic hetero...
EIF4A3 facilitates METTL3-mediated m6A methylation of circPCMTD1 to drive bladder cancer progression via miR-3681-5p/HPSE axis [0.03%]
EIF4A3通过miR-3681-5p/HPSE轴促进METTL3介导的circPCMTD1上的m6A甲基化以驱动膀胱癌进展
Lingbao Xiang,Yutong Li,Xuan Dong et al.
Lingbao Xiang et al.
Background: Bladder cancer (BCa) is a common urological malignancy with high recurrence rates and limited treatment options for advanced disease. Circular RNAs (circRNAs) are emerging as key regulators of cancer progressi...
TRPM7-mediated calcium signaling contributes to Hyperglycemia-induced mitochondrial dysfunction and apoptosis in retinal Müller cells [0.03%]
TRPM7介导的钙信号参与高糖引起的视网膜Müller细胞线粒体功能障碍及凋亡
Zhen Guo,Jing Tian,Xinyu Wei et al.
Zhen Guo et al.
Calcium signaling dysregulation is a critical trigger of mitochondrial dysfunction in metabolic disorders, yet the upstream mechanisms linking hyperglycemic stress to organellar Ca2+ overload remain poorly defined. The transient receptor po...
Targeting lipoprotein lipase-positive macrophage-driven GDF-15 expression alleviates cancer Cachexia in obese head and neck squamous cell carcinoma [0.03%]
靶向低密度脂蛋白脂酶阳性巨噬细胞驱动的GDF-15表达可缓解肥胖头颈部鳞状细胞癌患者的恶病质状况
Yu-Jia Guo,Ran Zhao,Yue-Han Li et al.
Yu-Jia Guo et al.
Head and neck squamous cell carcinoma (HNSCC) is often associated with dysphagia and malnutrition, predisposing patients to cancer cachexia, which adversely affects postoperative prognosis and survival. Obese patients may exhibit underlying...
BRD8 promotes non-small cell lung cancer progression by stabilizing MBD2 and activating the MAPK pathway [0.03%]
BRD8通过稳定MBD2和激活MAPK途径促进非小细胞肺癌进展
Li Dong,Yuchen Zhou,Qingwei Cui et al.
Li Dong et al.
Lung cancer is the leading cause of cancer-related mortality worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cases with limited therapeutic options and poor clinical outcomes. Bromodomain-contain...
Hypoxia remodels circSTX6 nuclear export through URH49-ALYREF to drive IGF1-mediated bladder cancer progression [0.03%]
缺氧通过URH49-ALYREF重塑circSTX6核输出以驱动IGF1介导的膀胱癌进展
Yuhan Chen,Juntao Zhuang,Hao Yu et al.
Yuhan Chen et al.
Background: Although circRNAs are increasingly implicated in tumor biology, most studies emphasize expression changes while overlooking subcellular distribution. The mechanisms governing circRNA nuclear export in bladder ...
Integrative spatiotemporal analysis uncovers an Fto-mediated epigenetic-metabolic axis governing myocardial ischemic injury [0.03%]
整合时空分析揭示了一个由Fto介导的表观遗传-代谢轴，该轴调控心肌缺血损伤
Ruolan Chen,Xuezhe Wang,RuoFeng Wang et al.
Ruolan Chen et al.
Fat mass and obesity-associated protein (Fto), a pivotal RNA N6-methyladenosine (m6A) demethylase, is critically involved in the progression of myocardial infarction (MI). However, the role of Fto in MI remains controversial; divergent obse...
Guangyuan Li,Mingyu Peng,Mengxue Li et al.
Guangyuan Li et al.
Pyroptosis is a form of programmed cell death mediated by gasdermin proteins, with GSDMD and GSDME being the most extensively studied. Inflammatory caspases-1 or caspases-4/5/11 cleave GSDMD and release its pore-forming fragment GSDMD-NT, w...
ILF3 promotes proliferation and invasion of hepatocellular carcinoma cells through STAT3 phosphorylation and formation of an endogenous complex with SRPK1 [0.03%]
ILF3通过STAT3磷酸化和与SRPK1形成内源性复合物促进肝癌细胞增殖和侵袭
Jianjian Yu,Yushan Yang,Zhuangyao Guo et al.
Jianjian Yu et al.
Interleukin enhancer-binding factor 3 (ILF3/NF90) is a multifunctional nuclear factor implicated in diverse malignancies, yet whether ILF3 engages functionally relevant protein-protein interactions within hepatocellular carcinoma (HCC) sign...
Extracellular regucalcin blocks the proliferation and metastatic activity of SK-N-SH human neuroblastoma cells by targeting diverse signaling pathways: Involvement in the cancer cell microenvironment [0.03%]
胞外regucalcin通过靶向多种信号通路阻断SK-N-SH人神经母细胞瘤细胞的增殖和转移活性：在癌细胞微环境中的作用
Masayoshi Yamaguchi,Mayumi Jijiwa,Noriaki Shimokawa et al.
Masayoshi Yamaguchi et al.
Regucalcin plays an inhibitory role in various cell signaling systems, including calcium signaling. Recent studies have demonstrated its role as a cancer-suppressing protein. Notably, extracellular regucalcin, which is present in the serum,...