CCN3/IMP3/HIF1α positive feedback loop enhances malignant progression of triple-negative breast cancer [0.03%]
CCN3/IMP3/HIF1α 正反馈环路增强三阴性乳腺癌恶性进展
Seogho Son,Seohee Jo,Hogeun Lim et al.
Seogho Son et al.
Cancer cells are often exposed to a hypoxic environment due to indiscriminate proliferation and incomplete vasculature formation. Hypoxia-inducible factor-1 (HIF-1), which is induced by a hypoxic environment, promotes tumor malignancy by re...
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway [0.03%]
BMI-1过表达通过TIME途径缓解维生素D缺乏诱导的肺纤维化
Jinge Zhang,Mingxin Huang,Jiawen Zhou et al.
Jinge Zhang et al.
Vitamin D deficiency is increasingly linked to senescence-associated pulmonary fibrosis (SAPF), yet the underlying mechanisms remain incompletely understood. Here, we demonstrate that mesenchymal cell-specific overexpression of Bmi-1 signif...
Macrophage-derived exosome miR-146a-5p modulates PNKP/DDOST/JAGN1 complex to regulate NETs formation in atherosclerosis [0.03%]
巨噬细胞源性外泌体miR-146a-5p通过调节PNKP/DDOST/JAGN1复合物调控动脉粥样硬化中NETs形成
Zhen Liu,Wei Zhang,Yihang Li et al.
Zhen Liu et al.
Background: The progression of atherosclerosis (AS) is closely associated with neutrophil extracellular trap (NET) formation, yet the regulatory mechanisms between macrophages and neutrophils remain unclear. ...
Mitsugumin 53 improves myocardial ischemia-reperfusion injury by promoting iPSCs survival through regulating AnxA6 axis [0.03%]
Mitsugumin 53通过调节AnxA6轴促进诱导多能干细胞存活从而改善心肌缺血再灌注损伤
Xiudi Pan,Lingling Xu,Dunzheng Han et al.
Xiudi Pan et al.
Myocardial ischemia-reperfusion injury (MIRI) remains a significant challenge in cardiac therapy. Regenerative strategies like induced pluripotent stem cells (iPSCs) and protein-based therapies have shown promise in cardiac repair and regen...
PDZK1, a direct target of Gli2, promotes FGFR3 trafficking and proliferation in colorectal cancer [0.03%]
Gli2的直接靶基因PDZK1通过促进结直肠癌中FGFR3的转运和增殖发挥作用
Hui Wang,Defu Li,Zhengping Yu et al.
Hui Wang et al.
In colorectal cancer (CRC), dysregulated Hedgehog (Hh) and fibroblast growth factor receptor 3 (FGFR3)-related pathways drive tumor progression, but their molecular crosstalk remains poorly understood. Here, we demonstrate that the scaffold...
Advances in cardiac cell interaction studies: Implications for heart disease treatment [0.03%]
心脏细胞相互作用研究进展及其对心脏病治疗的意义
Liang Huang,Bingbing Xie,Andy Peng Xiang et al.
Liang Huang et al.
Heart disease remains a leading cause of significant health threats, posing substantial risks to global public health. However, owing to the incomplete understanding of the mechanisms underlying cell-cell interactions within the heart, effe...
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis [0.03%]
脂肪来源的间充质干细胞外泌体通过调节KEAP1/NRF2/HO-1轴保护角质形成细胞免受高糖损伤
Yixuan Yuan,Shijie Song,Yujie Xiao et al.
Yixuan Yuan et al.
Hyperglycemia exacerbates diabetic chronic wounds by inducing oxidative damage and epithelial-mesenchymal transition (EMT), impairing re-epithelialization. This study investigated the protective role of adipose-derived mesenchymal stem cell...
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis [0.03%]
自噬调控的Keap1/Nrf2信号通路在氧化应激诱导的终板软骨细胞凋亡中的作用及机制研究
WenJing Wang,Kui Deng,WenZhao Chen et al.
WenJing Wang et al.
Background: Intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain, involves oxidative stress, impaired autophagy, and apoptosis. However, the dynamic crosstalk among Kelch-like ECH-associated p...
MiR-383-3p attenuates sepsis-induced myocardial ferroptosis by targeting ATF4 and inhibiting the ATF4-CHOP-CHAC1 signaling axis [0.03%]
miR-383-3p通过靶向ATF4并抑制ATF4-CHOP-CHAC1信号轴缓解脓毒症诱导的心肌铁死亡
Yazhou Li,Yan Shao,Jie Su et al.
Yazhou Li et al.
Objective: To investigate the role and mechanism of miR-383-3p in sepsis-induced myocardial dysfunction (SIMD), with a focus on ferroptosis. Methods: ...
PGM5 - AS1 regulates ferroptosis - Mediated gastric cancer cell behavior via ERK signaling pathway [0.03%]
PGM5-AS1通过ERK信号通路调节胃癌细胞铁死亡行为
Shichen Sun,Mengying Luo,Xiuzhu Zhan et al.
Shichen Sun et al.
Background: Gastric cancer (GC) remains a globally significant malignancy with high morbidity. Long non-coding RNAs (lncRNAs) are increasingly recognized as pivotal modulators in tumor biology. However, the involvement of...