SPP1 promotes fatty acid synthesis in macrophages to drive silicosis [0.03%]
SPP1促进巨噬细胞的脂肪酸合成以驱动硅肺病的发展
Xinchun Chen,Tian Li,Jiashuo Wang et al.
Xinchun Chen et al.
Osteopontin (SPP1) plays a critical role in the initiation and progression of silicosis, but whether macrophage-derived SPP1 regulates lipid metabolism during silicosis remains unclear. In this study, RNA sequencing of lung tissues from sil...
β-TrCP targets nucleolin and modulates phase separation to restrict ribosome biogenesis in myocardial infarction hearts [0.03%]
β-TRCP通过靶向核不均一核糖核蛋白C并调控相分离限制心肌梗死心脏核糖体生成
Junchu Tu,Huiling Zhang,Tonggan Lu et al.
Junchu Tu et al.
Myocardial infarction (MI) remains a significant global health challenge, as limited long-term efficacy of coronary interventions is largely due to inadequate cardiomyocyte (CM) regeneration. Ribosome biogenesis, a key driver of cell regene...
Pan-cancer analysis reveals the prognostic relevance of NUP54 and its association with HIF-1α-related glycolytic phenotypes in lung adenocarcinoma [0.03%]
泛癌分析揭示了NUP54的预后相关性及其与HIF-1α相关的糖酵解表型在肺腺癌中的关联
Peng Cheng,Chengru Song,Qian Han et al.
Peng Cheng et al.
The role of the nuclear pore protein NUP54 in tumorigenesis and progression remains unclear. By integrating multiomics data from TCGA, GTEx, CPTAC, and other sources, in this study, the first pan-cancer landscape of NUP54 was systematically...
The effects of long-term aerobic exercise on prostate cancer-induced adipose tissue wasting: Browning to the rescue? [0.03%]
长期有氧运动对前列腺癌引起的脂肪组织消耗的影响：“褐变以救援？”
Alexandra Moreira-Pais,Daniel Moreira-Gonçalves,Paula A Oliveira et al.
Alexandra Moreira-Pais et al.
The loss of adipose tissue has been emerging as a key component of cancer-related body wasting. One of the underlying causes suggested for this loss is the browning of the white adipose tissue. However, exercise, a promising therapeutic str...
Li Yi,Yilin Li,Xianhao Xiao et al.
Li Yi et al.
Uncoordinated 93 homolog B1 (UNC93B1) is a key innate immune regulator that affects the function of pattern recognition receptors. UNC93B1 is responsible for governing the intracellular trafficking and activation of nucleic acid-sensing TLR...
NDUFA4L2 acts as a mitochondrial checkpoint against ferroptosis in hypoxic clear cell renal cell carcinoma [0.03%]
NDUFA4L2作为缺氧条件下透明细胞肾细胞癌铁死亡的线粒体检查点
Xin Sun,Qirui Zhou,Yayun Wu et al.
Xin Sun et al.
This study aimed to define the functional role of the HIF-1α target gene NDUFA4L2 in clear cell renal cell carcinoma (ccRCC), specifically its regulation of mitochondrial function and the ferroptosis cell death pathway. Through TCGA data a...
Nicotinamide N-methyltransferase as a stress-responsive metabolic-epigenetic regulator of tubular senescence in chronic kidney disease [0.03%]
烟酰胺N-甲基转移酶作为应激反应型代谢-表观遗传调节因子介导慢性肾脏病中的肾小管衰老
An Liu,Xiao-Juan Zhu,Wei-Dong Sun et al.
An Liu et al.
Chronic kidney disease (CKD) is characterized by persistent cellular stress, tubular dysfunction, and progressive tubulointerstitial fibrosis. Increasing evidence suggests that senescence of renal tubular epithelial cells (RTECs) represents...
Znrf2-mediated ST2L degradation limits IL-33/ST2L anti-fibrotic signaling and promotes post-infarction cardiac fibrosis [0.03%]
Znrf2介导的ST2L降解限制了IL-33/ST2L抗纤维化信号并促进心梗后的心脏纤维化
Hailong Bao,Runze Huang,Xin Chen et al.
Hailong Bao et al.
Myocardial infarction (MI) remains a major cause of heart failure, largely driven by maladaptive ventricular remodeling and excessive cardiac fibrosis. The IL-33/ST2L axis exerts cardioprotective and anti-fibrotic effects, but how the avail...
Tubular basement membrane damage promotes renal fibrosis via an ETV5/TGFB1/SOX9 axis in proximal tubular epithelial cells after acute kidney injury [0.03%]
急性肾损伤后近端小管上皮细胞中管状基膜损害通过ETV5/TGFB1/SOX9轴促进肾纤维化
AMina Ka Dier,Weiran Zhou,Nana Song et al.
AMina Ka Dier et al.
The interaction between injured proximal tubular epithelial cells (PTECs) and the microenvironment has been widely associated with post-AKI fibrosis; however, the underlying mechanisms remain largely unclear. In this study, we identified th...
Morroniside alleviates CoCrMo particle-induced osteogenic impairment by activating Wnt/β-catenin signalling [0.03%]
Morroniside通过激活Wnt/β-catenin信号通路缓解CoCrMo颗粒诱导的成骨障碍
Jing Han,Zhiqi Zhu,Shiya Gao et al.
Jing Han et al.
Periprosthetic osteolysis (PPO) is the main cause of aseptic loosening after total joint arthroplasty, often resulting from wear particle-induced osteogenic impairment. Morroniside (Mor), a major bioactive iridoid glycoside from C. officina...