Oscillatory shear stress mediates endothelial cell senescence by regulating endoplasmic reticulum stress through HMOX1 [0.03%]
HMOX1调节内质网应激介导振荡剪切应力下内皮细胞衰老
Yunan Kang,Xiaoyun Zhang,Hong Li et al.
Yunan Kang et al.
Oscillatory shear stress (OSS) can induce senescence in endothelial cells (ECs), driving atherosclerosis (AS), while the role of endoplasmic reticulum stress (ERS) remains unclear. OSS induced senescence in ECs by increasing SA-β-gal stain...
Exosomal LRG1 derived from highly metastatic non-small cell lung cancer cells accelerates growth, metastasis, and angiogenesis by transcriptional factor NFKB1-mediated SHH upregulation [0.03%]
来自高转移性非小细胞肺癌细胞的exo LRGL通过转录因子NFKB1介导SHH上调促进生长、转移和血管生成
Hao Wu,Chao Zeng,Guodong Wu et al.
Hao Wu et al.
Neovascularization, a critical interstitial component, facilitates rapid tumor cell proliferation, metastasis, and recurrence. Communication between tumor-derived exosomes and endothelial cells promotes tumor progression and angiogenesis. L...
Epigenetics modulation of drug resistance pathways in advanced lung cancer [0.03%]
表观遗传调控在肺癌耐药机制中的作用
Usamah Sayed,Amina Dawood Suleman,Shaker Al-Hasnaawei et al.
Usamah Sayed et al.
The emergence of therapeutic resistance represents a fundamental barrier to successful long-term management of advanced lung cancer, contributing significantly to cancer-related mortality worldwide. This comprehensive review synthesizes cur...
HMMR is a novel prognostic marker and a potential therapeutic target for colon cancer [0.03%]
HMMR是一个新的预后标志物和结直肠癌治疗潜在靶点
Lin Fang,Jiabao Lin,Donghua Huang et al.
Lin Fang et al.
The hyaluronan-mediated motility receptor (HMMR) is a critical regulator of tumor progression, yet its specific role in colon cancer remains poorly understood. This study aims to better understand the molecular mechanism of HMMR in colon ca...
Exercise attenuates hepatic lipid accumulation via VDR/AMPK-mediated autophagy activation in vitamin D-deficient mice [0.03%]
运动通过维生素D缺乏小鼠中的VDR/AMPK介导的自噬激活减轻肝脏脂质积累
Jing-Jing Liu,Yan-Jun Niu,Xiao-Ning Cui et al.
Jing-Jing Liu et al.
Vitamin D deficiency (VDD) is a global health issue associated with hepatic lipid accumulation. Although exercise serves as an effective non-pharmacological intervention for metabolic disorders, its molecular mechanisms remain unclear. This...
Mechanical stretch accelerates endothelial cell injury by inducing endoplasmic reticulum stress-mediated, autophagy-dependent ferroptosis in endothelial cells [0.03%]
机械拉伸通过内质网压力介导的自噬依赖性铁死亡促进血管内皮细胞损伤
Gang Dong,Shiyao Chen,Lei Wang et al.
Gang Dong et al.
Portal hypertension is characterized by elevated pressure within the portal venous system, commonly resulting from cirrhosis. As portal hypertension progresses, the portal vein dilates and subjected its endothelial cells (ECs) to mechanical...
TWEAK exacerbates allergic conjunctivitis via PKM2-dependent NF-κB activation and macrophage M1 polarization [0.03%]
TWEAK通过PKM2依赖的NF-κB活化和巨噬细胞M1极化加重过敏性结膜炎
Yang Yang,Yuezhi Zhang,Jingfan Fu et al.
Yang Yang et al.
Background: Allergic conjunctivitis (AC) is a prevalent ocular inflammatory disease with unmet therapeutic needs. This study aimed to investigate whether TWEAK regulates NF-κB activation and macrophage polarization, and ...
DDX5 is required for JAK2V617F-induced cell proliferation and tumorigenesis independent of its RNA helicase activity [0.03%]
DDX5通过RNA解旋酶非依赖的方式促进JAK2V617F诱导的细胞增殖和肿瘤发生
Kengo Takeda,Kenji Tago,Satoshi Ohta et al.
Kengo Takeda et al.
The constitutively active Janus kinase 2 mutant (JAK2V617F) is a major driver of myeloproliferative neoplasms (MPNs). Our previous studies demonstrated that JAK2V617F upregulates the expression of the RNA helicase DDX5 via activation of the...
Berberine derivative C51 modulates cGAS-STING-TIM-3 axis to reverse immune evasion and inhibit lung cancer growth [0.03%]
异构表儿茶素姜黄素C51通过调节cGAS-STING-Tim-3轴逆转免疫逃逸并抑制肺癌进展
Yuyan Bao,Bing Hong,Kaiping Liu et al.
Yuyan Bao et al.
Berberine, also known as berberine hydrochloride, is an isoquinoline alkaloid extracted from natural plants, exhibiting a wide range of biological activities, including anti-inflammatory, antioxidant, antitumor, antibacterial, antiviral, an...
siRASA1 in vascular endothelial cells alleviates subretinal fibrosis through inhibiting macrophage-myofibroblast transdifferentiation via SHH signaling pathway [0.03%]
血管内皮细胞中的siRASA1通过SHH信号通路抑制巨噬细胞肌成纤维细胞转分化从而缓解视网膜下纤维化
Lei Jiang,Zihang Xu,Jingyang Ma et al.
Lei Jiang et al.
Subretinal fibrosis (SRF) is a vision-threatening complication of neovascular age-related macular degeneration (nAMD) driven by angiogenesis, inflammation, and collagen deposition，which is refractory to current anti-VEGF treatments. This stu...