IL-33/ST2 axis delays disc degeneration through PI3K/AKT-dependent regulation of nucleus pulposus cell proliferation and apoptosis [0.03%]
Haoran Wang,Ping Zhou,Yanrui Chen et al.
Haoran Wang et al.
Objective: To investigate the proliferation and apoptosis of nucleus pulposus cells stimulated by IL-33, as well as the activation of the PI3K/AKT signaling pathway in these cells, and to determine whether this pathway is...
Reactivating mitochondrial quality control via the Nrf2 pathway to combat metabolic stress in diabetic osteoarthritis [0.03%]
Yang Chen,Juan Xiao,Yanmin Yu et al.
Yang Chen et al.
The intersection of diabetes mellitus (DM) and osteoarthritis (OA) defines a distinct metabolic phenotype, commonly termed diabetic osteoarthritis (DOA), in which systemic metabolic toxicity independently accelerates articular degeneration....
PHC2 promotes hepatocellular carcinoma progression and serves as a robust prognostic biomarker: A pancancer multiomics and clinical validation study [0.03%]
Qiang Wang,Yuntao Ye,Shu Qin et al.
Qiang Wang et al.
Purpose: Polyhomeotic homolog 2 (PHC2) is a key component of Polycomb repressive complex 1, yet its clinical significance and biological function in hepatocellular carcinoma (HCC) remain unclear. This study aimed to eluci...
Clec7a promotes hippocampal microglial activation in rats with status epilepticus via inducing the TLR4/MyD88/NF-κB signaling pathway [0.03%]
Fangfang Dai,Yan-Hui Chen
Fangfang Dai
Microglial polarization imbalance between pro-inflammatory M1 and anti-inflammatory M2 phenotypes is a key mechanism in epilepsy-related neuroinflammation. This study explores the role of C-type lectin domain containing 7A (Clec7a) in M1 mi...
RARG promotes gastric cancer progression by activating PMEPA1 transcription and Wnt/β-catenin signalling [0.03%]
Long Qin,Fei Wen,Shuyan Guo et al.
Long Qin et al.
Objective: Gastric cancer (GC) has a complex pathogenesis driven by infection, genetic mutations, epigenetic reprogramming, and tumor microenvironment (TME) remodelling, all of which contribute to tumorigenesis, metastasi...
ST7 binds YBX1 to suppress MMP14 expression and inhibit metastasis in non-small cell lung cancer [0.03%]
Yang Qin,Yahan Chen,Qian Cao et al.
Yang Qin et al.
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and a major contributor to cancer-related deaths globally. The mechanisms of NSCLC metastasis, largely driven by epithelial-mesenchymal transition (EMT), remain incom...
Yuxin Zan,Lin Chen,Liming Ma et al.
Yuxin Zan et al.
Background: Renal fibrosis (RFib) is a final common pathway in chronic kidney disease (CKD) progression. Although 5-methylcytosine (m5C) RNA modification can regulate mRNA fate, its role in RFib and redox-regulated cell d...
SRY-box transcription factor 7 functions as a tumor suppressor regulating Wnt signaling and cancer stemness with its promoter methylation as a potential biomarker [0.03%]
Lihua Xie,Jun Zhou,Jianlian Xie et al.
Lihua Xie et al.
Background: Wnt signaling, critical for development, is often dysregulated in cancer via genetic or/and epigenetic changes. SOX7, a high mobility group protein, is downregulated in cancers, but its alterations and underly...
CCL17 drives the expression of MMP9 and MMP13 expression via ERK1/2 and NF-κB signaling pathways in rheumatoid arthritis [0.03%]
Thivya Balendran,Tetiana Hourani,Subothini Ganeshalingam et al.
Thivya Balendran et al.
Chemokine (CC motif) ligand 17 (CCL17), an inflammatory chemokine, has been shown to mediate pain and inflammation in animal models of arthritis. However, the specific molecular mechanisms by which CCL17 mediates its inflammatory functions ...
UFL1 deficiency impairs skeletal muscle development by activating PERK/eIF2α/ATF4/CHOP pathway-dependent apoptosis [0.03%]
Junjie Xu,Mali Guo,Ping Li et al.
Junjie Xu et al.
Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1), the essential E3 ligase in the UFMylation system, plays a crucial yet undefined role in skeletal muscle development. In this study, our primary objective was to elucidate the function and ...