Athanasios Chatzopoulos,Constantinos Kolliopoulos,Yizhen Yin et al.
Athanasios Chatzopoulos et al.
CD44-hyaluronan interactions play a significant role in the progression of aggressive tumors. We generated non-native ligands for CD44 by identifying macrocyclic peptides that interact with the hyaluronan-binding domain of CD44. We investig...
Distal-less homeobox 5 transactivated by MYCN contributes to progression of neuroblastoma through AKT signaling pathway [0.03%]
MYCN激活的Distal-less同源盒5通过AKT信号通路促进神经母细胞瘤的发展进展
Yi He,Xiaosi Yu,Chenzhao Feng et al.
Yi He et al.
Neuroblastoma is one of the highest incidence solid tumors of childhood. Therapy for neuroblastoma with MYCN proto-oncogene (MYCN) amplification is of great challenge, due to its aggressive invasion and chemoresistance. In our study, differ...
Multi-omics reveals that QKI-mediated NIN exon 18 splicing drives breast cancer cell progression [0.03%]
多组学揭示QKI介导的NIN第18外显子剪接驱动乳腺癌细胞进展
Weiming Chen,Zhiwei Liao,Yingti He et al.
Weiming Chen et al.
Breast cancer is a leading cause of cancer-related mortality in women worldwide. Aberrant alternative splicing contributes to BRCA progression, but the role of splicing factors such as QKI and their regulation of specific splicing events, s...
Core signaling pathways in renal ischemia-reperfusion injury: network regulation and therapeutic prospects [0.03%]
肾缺血再灌注损伤的核心信号通路：网络调节与治疗前景
Rui Yan,Yalong Zhang,Zewen Li et al.
Rui Yan et al.
Renal ischemia-reperfusion injury (RIRI) is one of the key mechanisms underlying acute kidney injury (AKI) and delayed recovery of renal transplant function. Its pathological process is accompanied by various changes, including oxidative st...
APC/C coactivators Cdh1 and Cdc20: Mechanistic insights into cancer progression and therapeutic opportunities [0.03%]
APC/C辅助激活因子Cdh1和Cdc20：促进癌症进展及治疗机会的机制见解
Yaqi Zhang,Haoyi Wang,Kaifan Li et al.
Yaqi Zhang et al.
The dysregulation of the cell cycle is intricately linked to the pathogenesis and progression of numerous human diseases, especially for malignant tumors. The anaphase-promoting complex/cyclosome (APC/C), an evolutionarily conserved protein...
Ginsenoside inhibits aerobic glycolysis in hepatocellular carcinoma through the hsa-miR-139-5p/AURKA axis [0.03%]
人参皂苷通过hsa-miR-139-5p/AURKA轴抑制肝癌细胞的糖酵解作用
Xiaoping Wei,Hong Zhu,Henghai Yu et al.
Xiaoping Wei et al.
Purpose: Ginsenoside (Rg3) is an important small-molecule with anti-tumor and immune-enhancing properties, mainly used in clinical adjuvant chemotherapy for hepatocellular carcinoma (HCC). In this study, we explored the a...
ROCK1 drives colorectal cancer liver metastasis via PRKCH-mediated bioenergetic reprogramming [0.03%]
ROCK1通过PRKCH介导的生物能量重编程驱动结直肠癌肝转移
Yue Luo,Yishan Xu,Xi Chen et al.
Yue Luo et al.
Colorectal cancer (CRC) metastasis, particularly to the liver, is a primary contributor to cancer-related deaths, yet the underlying molecular drivers remain insufficiently defined. This study identifies Rho-associated coiled-coil kinase 1 ...
sIL-11 exacerbates cisplatin-induced acute kidney injury by facilitating apoptosis in renal tubular epithelial cells via ERK1/2-Drp1/TFEB-mediated defective autophagy [0.03%]
白细胞介素11通过ERK1/2-Drp1/TFEB介导的自噬缺陷促进顺铂诱导的急性肾损伤中的肾小管上皮细胞凋亡
Danping Tao,Wenting Wu,Zerong Zheng et al.
Danping Tao et al.
Cisplatin-induced acute kidney injury (Cis-AKI) lacks targeted therapies. Here we identify interleukin-11 (IL-11) as a key driver of tubular injury that couples mitochondrial dynamics to autophagic flux in renal tubular epithelial cells. In...
Mitochondrial homeostasis collapse to cardiac remodeling: From mechanisms to novel targeted therapeutic avenues [0.03%]
线粒体稳态失衡介导的心脏重塑：从机制研究到新的治疗策略
Qi-Yun Liu,Fan-Liang Meng,Jia-Min Du et al.
Qi-Yun Liu et al.
Myocardial remodeling is a common pathological process in various cardiovascular diseases (CVDs) and represents the heart's adaptive response to pressure or volume overload. However, prolonged myocardial remodeling often leads to a progress...
Polarity protein Par6: Unraveling its mechanisms in tumor development and research advances [0.03%]
极性蛋白Par6在肿瘤发生中的作用及研究进展
Wei Xu,Yilin Fang,Kaixuan Li et al.
Wei Xu et al.
Partitioning-defective protein 6 (Par6), is a core regulator of cell polarity whose dysregulation is increasingly implicated in tumorigenesis and progression. This review aims to elucidate the molecular basis by which Par6 promotes tumor de...