Phosphoproteomic analysis of successive Jurkat CD19-CAR generations reveals TCRζ-driven signalling [0.03%]
对连续几代的Jurkat CD19-CAR进行磷酸化蛋白质组分析，揭示了由TCRζ驱动的信号转导现象
Aurora Callahan,Ryan Z Puterbaugh,Timothy Ro et al.
Aurora Callahan et al.
Although chimeric antigen receptor (CAR) T cell therapy has revolutionised individualised cancer therapies for relapsed/refractory lymphomas, low long-term retention due to basal signalling (antigen-independent activation in the absence of ...
Characterizing the link between stunting and metabolic syndrome in developing nations [0.03%]
发展中国家儿童生长迟缓与代谢综合征关系的特征分析研究
Muhammad Rizky Malik Budu
Muhammad Rizky Malik Budu
Stunting, identified when a child's height exceeds 2 standard deviations below the World Health Organization (WHO) growth standard, is a global health concern with profound economic consequences. There is a perception that stunting increase...
Current mechanistic insights into biochemical properties and cellular functions of human Caf1 deadenylases [0.03%]
人类Caf1去腺苷酸化酶生化性质和细胞功能的当前机制见解
Li-Na Zhang,Jia-Hui Li,Huan-Xi Song et al.
Li-Na Zhang et al.
In eukaryotic cells, mRNA degradation is a critical regulatory step in mRNA metabolism. The removal of poly(A) tail at the 3'-end of mRNA, an initial and rate-limiting step in mRNA degradation termed mRNA deadenylation, is catalyzed by nume...
Sirt3-Bnip3 signaling axis alleviates myocardial ischemia/reperfusion-induced cardiac injury via regulating GSDME [0.03%]
Sirt3-Bnip3信号轴通过调节GSDME缓解心肌缺血再灌注损伤
Zhiqiang Yin,Xiong Jia,Bin Zhang et al.
Zhiqiang Yin et al.
Myocardial ischemia/reperfusion (MI/R) injury is a serious complication of myocardial infarction, resulting in acute cardiac dysfunction, arrhythmias, and potentially sudden death. However, the exact mechanisms of MI/R remain unclear. Mitoc...
The dysregulation of UPP1 incurred by METTL3 regulates the malignancy of esophageal squamous cell carcinoma in an m6A-YTHDC1-KLF5-mediated manner [0.03%]
METTL3通过m6A-YTHDC1-KLF5轴调控UPP1异常进而促进食管鳞癌恶性进展
Jing Chen,Zi-Xuan Zhu,Ping-Jin Yang et al.
Jing Chen et al.
Uridine phosphorylase 1 (UPP1) has been shown to catalyze the generation of ribose derived from uridine, to promote central carbon metabolism, and to collaborate with glucose to drive aerobic glycolysis in tumor cells, thereby playing an on...
Chlorogenic acid ameliorates chronic stress-induced depression-like behaviors in rats by inhibiting oxidative stress and neuroinflammation via the PI3K/Akt/Nrf2 pathway [0.03%]
氯ogenic酸通过PI3K/Akt/Nrf2信号通路抑制氧化应激和神经炎症来改善大鼠慢性压力引起的类似抑郁的行为
Siyu Wu,Qichao Tang,Hexin Zhang et al.
Siyu Wu et al.
Background: Chronic stress is a major risk factor for depression, with oxidative damage and neuroinflammation playing critical roles. Chlorogenic acid (CGA) is a natural polyphenol that exhibits robust neuroprotective and...
CDS1 deficiency promotes colorectal cancer progression by suppressing CDP-DAG-induced ferroptosis in MDSCs [0.03%]
CDS1缺陷通过抑制MDSC中CDP-DAG诱导的铁死亡促进结直肠癌进展
Chong Li,Wei Liu,Yanyan Zhang et al.
Chong Li et al.
Dysregulation of phospholipid metabolism has been increasingly recognized as a critical contributor to colorectal cancer (CRC) progression; however, the key molecular determinants governing this process remain incompletely defined. In this ...
Interaction of tumor cells and Cancer-associated fibroblasts in radiation-induced senescence [0.03%]
肿瘤细胞和癌症相关成纤维细胞在辐射诱导衰老下的相互作用
Johannes Raphael Kupka,Rita Gieringer,Sebahat Kaya et al.
Johannes Raphael Kupka et al.
Background: Despite significant progress in tumor therapy, recurrences continue to pose a major challenge in clinical oral oncology. Recent studies suggest that senescence and intercellular signaling within the tumor micr...
Evolving perspectives on lipid mediated cell-to-cell communication: The adenylyl cyclase signaling system [0.03%]
脂质介导的细胞间通讯的发展观点：腺苷酸环化酶信号系统
Joachim E Schultz
Joachim E Schultz
Decades after the discovery of the second messenger cyclic AMP, the regulation of multi-domain adenylyl cyclases remains poorly understood. Mammals express nine membrane-bound isoforms which share an identical domain architecture. These mAC...
Abnormal matrix viscosity promotes the progression of radiation-induced pulmonary fibrosis through integrin-β1/vinculin/FAK pathway in the presclerotic stage [0.03%]
异常基质粘度通过整合素-β1/连环蛋白/FAK通路促进成纤维化前期放射引起的肺纤维化进程
Jinran Chen,Kaining Guo,Lingfeng Xie et al.
Jinran Chen et al.
Stiffened extracellular matrix (ECM) accelerates fibroblast activation as well as fibrosis progression. However, the contribution of ECM to the progression of fibrosis is unclear when the sclerosis of the ECM is not obvious in the early sta...