Hexokinase 2 elevation links obesity to increased risk of acute kidney injury [0.03%]
己糖激酶2升高连接肥胖与急性肾损伤风险增加的关系
Hang Lv,Jing Li,Aijuan Wang et al.
Hang Lv et al.
Acute kidney injury (AKI) is a common complication with poor clinical outcomes, and patients with high body mass index (BMI) are particularly vulnerable, especially after major surgical procedures, though the underlying mechanisms remain un...
Exercise training attenuates high-fat diet-induced skeletal muscle atrophy by inhibiting Drp1-mediated cuproptosis in male mice [0.03%]
运动训练通过抑制Drp1介导的铜死亡减轻高脂饮食诱导的小鼠肌肉萎缩
Min Hu,Yiwen Yuan,Zhenxian An et al.
Min Hu et al.
Objective: The present study investigated the role of Drp1 in cuproptosis and its underlying mechanisms, while examining the effects of aerobic exercise on high-fat diet-induced skeletal muscle atrophy. These findings may...
Mitochondrial dysfunction in intervertebral disc degeneration: Linking oxidative stress, altered cell fate, and Matrix degeneration [0.03%]
线粒体功能障碍与椎间盘退变：氧化应激、细胞命运改变及基质降解之间的联系
Cong Zhang,Zuolong Wu,Rui Ran et al.
Cong Zhang et al.
Intervertebral disc degeneration (IVDD) is a major pathological basis of chronic low back pain and is closely associated with disrupted cellular homeostasis, extracellular matrix (ECM) imbalance, and chronic inflammation. In recent years, m...
Maresin-1 ameliorates renal oxidative stress and inflammation in diabetic kidney disease mice partially dependent on apolipoprotein D upregulation [0.03%]
maresin-1通过部分依赖载脂蛋白D的上调改善糖尿病肾病小鼠的肾脏氧化应激和炎症
Linlin Huang,Mengqin Tu,Tingting Zhou et al.
Linlin Huang et al.
Diabetic kidney disease (DKD) is a prevalent diabetic microvascular complication driven by persistent, unresolved renal inflammation, while specialized pro-resolving mediators (SPMs) represented by Maresin-1 (MaR1) have emerged as promising...
Laminin γ2-ITGβ1-PD-L1 axis mediates gastric cancer cell heterogeneity in response to GCMSCs via FAK/YAP pathway [0.03%]
laminin γ2-ITGβ1-PD-L1轴通过FAK/YAP途径介导胃癌细胞异质性响应GCMSCs
Li Sun,Xiaonuo Zhang,Yiping Hou et al.
Li Sun et al.
Background: Despite previous studies indicating that gastric cancer mesenchymal stromal cells (GCMSCs) raise PD-L1 levels in gastric cancer (GC) cells, the mechanisms underlying the heterogeneous responses of PD-L1Low and...
Targeting the adaptor protein Gab1 overcomes MET/Src-driven alectinib resistance in ALK-rearranged NSCLC [0.03%]
靶向适应性蛋白Gab1可克服MET/Src驱动的ALECTINIB引起的ALK重排NSCLC耐药问题
Hengyi Chen,Caiyu Lin,Chen Hu et al.
Hengyi Chen et al.
Background: In non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement, bypass signaling activation commonly leads to resistance against alectinib. Identifying key molecular targets that int...
Corrigendum to "SAR131675 exhibits anticancer activity on human ovarian cancer cells through inhibition of VEGFR-3/ERK1/2/AKT signaling pathway" [Cellular Signaling 111 (2023) 110856] [0.03%]
“SAR131675通过抑制VEGFR-3/ERK1/2/AKT信号通路对人类卵巢癌细胞具有抗癌活性”一文的勘误说明（ Cellular Signaling 111 (2023) 110856）
Zeinab Babaei,Mojtaba Panjehpour,Hadi Parsian et al.
Zeinab Babaei et al.
Published Erratum
Cellular signalling. 2026 Jul 22:112740. DOI:10.1016/j.cellsig.2026.112740 2026
Multi-omics and artificial intelligence nominate PCLAF as a prognostic and druggable target for hepatitis B virus-associated hepatocellular carcinoma [0.03%]
多组学和人工智能联合发现PCLAF是乙肝相关肝癌预后标志物及可成药靶点
Feihong Shu,Yidan Chen,Xiaorong Yang et al.
Feihong Shu et al.
Background: PCLAF (PCNA clamp-associated factor) is a protein involved in DNA replication and DNA repair. Aberrant PCLAF expression has been reported in multiple malignancies and is associated with tumor progression and p...
Novel role of GADD45A in synergistic regulation of neuronal ferroptosis and apoptosis after spinal cord injury via NF-κB signaling [0.03%]
GADD45A通过NF-κB信号在脊髓损伤后协同调节神经元铁死亡和凋亡中的新作用
Zhichao Luo,Hao Yu,Peng Chen et al.
Zhichao Luo et al.
Ferroptosis and apoptosis are major mechanisms of neuronal injury after spinal cord injury (SCI), but regulators that coordinate both processes remain poorly defined. In this study, we analyzed 188 ferroptosis-related differentially express...
IER5L promotes p53 degradation via TRAF7-mediated ubiquitination to facilitate EMT and colorectal cancer malignancy [0.03%]
IER5L通过TRAF7介导的泛素化促进p53降解从而促进上皮间质转化和结直肠癌恶性进展
Guoyu-Li,Xudong-Yang,Qing-Feng et al.
Guoyu-Li et al.
Colorectal cancer is a leading cause of cancer-related death worldwide. The role of immediate early response 5-like (IER5L) in colorectal cancer remains unknown. This study investigated IER5L expression, biological function, and molecular m...